The non-intrusive nature and high accuracy of face recognition algorithms have led to their successful deployment across multiple applications ranging from border access to mobile unlocking and digital payments. However, their vulnerability against sophisticated and cost-effective presentation attack mediums raises essential questions regarding its reliability. Several presentation attack detection algorithms are presented; however, they are still far behind from reality. The major problem with the existing work is the generalizability against multiple attacks both in the seen and unseen setting. The algorithms which are useful for one kind of attack (such as print) fail miserably for another type of attack (such as silicone masks). In this research, we have proposed a deep learning-based network called MixNet to detect presentation attacks in cross-database and unseen attack settings. The proposed algorithm utilizes state-of-the-art convolutional neural network architectures and learns the feature mapping for each attack category. Experiments are performed using multiple challenging face presentation attack databases such as Silicone Mask Attack Database (SMAD) and Spoof In the Wild with Multiple Attack (SiW-M). Extensive experiments and comparison with the existing state of the art algorithms show the effectiveness of the proposed algorithm.