As reported by Hong Kong Government in 2017, there are more than 1.5 million residents suffering from hearing impairment in Hong Kong. Most of them rely on Hong Kong Sign Language for daily communication while there are only 63 registered sign language interpreters in Hong Kong. To address this specific social issue and also facilitate the effective communication between the hearing impaired and other people, this paper introduces a word-level Hong Kong Sign Language(HKSL) dataset which currently includes 45 isolated words and at least 30 sign videos per word performed by different signers(more than 1500 videos in total now and still enlarging). Based on this dataset, this paper systemically compares the performances of various deep learning approaches, including (1) 2D histogram of oriented gradients(HOG) feature/pose estimation/feature extraction with long-short term memory(LSTM) layer; (2) 3D Residual Neural Network(ResNet) (3) (2+1)D Residual Neural Network, in HKSL recognition. Meanwhile, to further improve the accuracy of sign language recognition, this paper proposes a novel method called (3+2+1)D ResNet Model with Frame Selection which adopts blurriness detection with Laplacian kernel to construct highquality video clips and also combines both (2+1)D and 3D ResNet for recognizing the sign language. At the end, the experimental results show that the proposed method outperforms other deep learning approaches and attain an impressive accuracy of 94.6% in our dataset.