The detection and tracking of road signs plays a critical role in various autopilot application. Utilizing convolutional neural networks(CNN) mostly incurs a big run-time overhead in feature extraction and object localization. Although Klaman filter(KF) is a commonly-used tracker, it is likely to be impacted by omitted objects in the detection step. In this paper, we designed a high-efficient detector that combines ThunderNet and Region Growing Detector(RGD) to detect road signs, and built a fusion model of long short term memory network (LSTM) and KF in the state estimation and the color histogram. The experimental results demonstrate that the proposed method improved the state estimation accuracy by 6.4% and enhanced the Frames Per Second(FPS) to 41.