Fractal Dimension (FD) is widely used for image segmentation because of its successful approach toward quantifying texture information. In this paper, we present a FD-based multi-focus image fusion method that utilizes FD to identify focused regions, as the primary step for the multi-focus image fusion process. The algorithm aims to extract the local FD features of each multi-focus pair estimated using the differential box-counting method. A guided filter is employed to further specify the spatial information and increase the robustness of the FD features to noise. The outcome would be analyzed to achieve a focus map that identifies sharp regions in each partially focused image. Afterwards, the detected regions are combined into a single all-focused image. The experiments, along with the objective assessments, demonstrate the competitive performance of the proposed method compared to several state-of-the-art multi-focus image fusion methods.