Super-resolution aims at increasing the resolution and level of detail within an image. The current state of the art in general single-image super-resolution is held by nESRGAN+,which injects a Gaussian noise after each residual layer at training time. In this paper, we harness evolutionary methods to improve nESRGAN+ by optimizing the noise injection at inference time. More precisely, we use Diagonal CMA to optimize the injected noise according to a novel criterion combining quality assessment and realism. Our results are validated by the PIRM perceptual score and a human study. Our method outperforms nESRGAN+ on several standard super-resolution datasets. More generally, our approach can be used to optimize any method based on noise injection.