Face recognition system is vulnerable to many kinds of presentation attacks, so how to effectively detect whether the image is from the real face is particularly important. At present, many deep learning-based anti-spoofing methods have been proposed. But these approaches have some limitations, for example, global average pooling (GAP) easily loses local information of faces, single-scale features easily ignore information differences in different scales, while a complex network is prune to be overfitting. In this paper, we propose a face anti-spoofing approach using spatial pyramid pooling (SPP). Firstly, we use ResNet-18 with a small amount of parameter as the basic model to avoid overfitting. Further, we use spatial pyramid pooling module in the single model to enhance local features while fusing multi-scale information. The effectiveness of the proposed method is evaluated on three databases, CASIA-FASD, Replay-Attack and CASIA-SURF. The experimental results show that the proposed approach can achieve state-of-the-art performance.