Pedestrian Attribute Recognition (PAR) has received extensive attention during the past few years. With the advances of deep constitutional neural networks (CNNs), the performance of PAR has been significantly improved. Existing methods tend to acquire attribute-specific features by designing various complex network structures with additional modules. Such additional modules, however, dramatically increase the number of parameters. Meanwhile, the problems of class imbalance and hard attribute retrieving remain underestimated in PAR. In this paper, we explore the optimization mechanism of the training processing to account for these problems and propose a new loss function called Multi-label Contrastive Focal Loss (MCFL). This proposed MCFL emphasizes the hard and minority attributes by using a separated re-weighting mechanism for different positive and negative classes to alleviate the impact of the imbalance. MCFL is also able to enlarge the gaps between the intra-class of multi-label attributes, to force CNNs to extract more subtle discriminative features. We evaluate the proposed MCFL on three large public pedestrian datasets, including RAP, PA-100K, and PETA. The experimental results indicate that the proposed MCFL with the ResNet-50 backbone is able to outperform other state-of-the-art approaches in comparison.