The main challenges of visual question answering (VQA) lie in modeling an alignment between image and question to find out informative regions in images that related to the question and reasoning relations among visual objects according to the question. In this paper, we propose question-guided relational reasoning in multi-scales for visual question answering, in which each region is enhanced by regional attention. Specifically, we present regional attention, which consists of a soft attention and a hard attention, to pick up informative regions of the image according to informative evaluations implemented by question-guided soft attention. And combinations of different informative regions are then concatenated with question embedding in different scales to capture relational information. Relational reasoning can extract question-based relational information between regions, and the multi-scale mechanism gives it the ability to analyze relationships in diversity and sensitivity to numbers by modeling scales of relationships. We conduct experiments to show that our proposed architecture is effective and achieves a new state-of-the-art on VQA v2.