Despite the impressive advancement achieved in object detection, the detection performance of small object is still far from satisfactory due to the lack of sufficient detailed appearance to distinguish it from similar objects. Inspired by the positive effects of super-resolution for object detection, we propose a general framework that can be incorporated with most available detector networks to significantly improve the performance of small object detection, in which the low-resolution image is super-resolved via generative adversarial network (GAN) in an unsupervised manner. In our method, the super-resolution network and the detection network are trained jointly and alternately with each other fixed. In particular, the detection loss is back-propagated into the super-resolution network during training to facilitate detection. Compared with available simultaneous super-resolution and detection methods which heavily rely on low-/high-resolution image pairs, our work breaks through such restriction via applying the CycleGAN strategy, achieving increased generality and applicability, while remaining an elegant structure. Extensive experiments on datasets from both computer vision and remote sensing communities demonstrate that our method works effectively on a wide range of complex scenarios, resulting in best performance that significantly outperforms many state-of-the-art approaches.