Human-object interactions detection is an essential task of image inference, but current methods can’t efficiently make use of global knowledge in the image. To tackle this challenge, in this paper, we propose a Human-Centric Parsing Network (HCPN), which integrates global structural knowledge to infer human-object interactions. In HCPN, a semantic parse graph is first constructed by binding human-object relationships, edge features and node features, where the detected human box in image is regarded as the center node and other detected boxes are linked to it. Second, based on the message passing mechanism, edge features and node features with the relation graph are updated and finally, HCPN predicts human-object interactions and associated locations by a readout function. We evaluate our model on V-COCO dataset, and a great improvement is achieved compared with state-of-the-art methods.