Lung ultrasound imaging is reaching growing interest from the scientific community. On one side, thanks to its harmlessness and high descriptive power, this kind of diagnostic imaging became largely adopted in sensitive applications, like the diagnosis and follow-up of preterm newborns in neonatal intensive care units. At the same time, novel image analysis and pattern recognition approaches can fully exploit the rich information contained in this data, making them attractive for the research community. In this work, we present a thorough analysis of recent deep learning networks and training strategies conducted on a vast and challenging multicenter dataset comprising 87 patients with different diseases and gestational ages. These approaches are firstly discussed in the context of lung respiratory status assessing through ultrasound imaging and then evaluated against a reference marker. The conducted analysis shed some light on this problem, by relating the criticisms that can mislead the training procedure and proposing some adaptations to the specific problem. The achieved results sensibly outperform that obtained by previous work, based on textural features, and narrow the gap with the visual score predicted by the human experts.

Cancer is one of the leading causes of death in the western world, with medical imaging playing a key role for early diagnosis. Focusing on breast cancer, one of the emerging imaging methodologies is Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI). The flip side of using DCE-MRI is in its long acquisition times, often causing the patient to move, resulting in motion artefacts, namely distortions in the acquired image that can affect DCE-MRI analysis. A possible solution consists in the use of Motion Correction Techniques (MCTs), i.e. procedures intended to re-align the post-contrast image to the corresponding pre-contrast (reference) one. This task is particularly critic in DCE-MRI, due to brightness variations introduced in post-contrast images by the contrast-agent flowing. To face this problem, in this work we introduce a new MCT for breast DCE-MRI leveraging Physiologically Based PharmacoKinetic (PBPK) modelling and Artificial Neural Networks (ANN) to determine the most suitable physiologically-compliant transformation. To this aim, we propose a Neural Registration Network relying on a very task-specific loss function explicitly designed to take into account the contrast agent flowing while enforcing a correct re-alignment. We compared the obtained results against some conventional motion correction techniques, evaluating the performance on a patient-by-patient basis. Results clearly show the effectiveness of the proposed approach, resulting as the best performing even when compares against other techniques designed to take into account for brightness variations.