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Inception Based Deep Learning Architecture for Tuberculosis Screening of Chest X-Rays

Dipayan Das, K.C. Santosh, Umapada Pal

Auto-TLDR; End to End CNN-based Chest X-ray Screening for Tuberculosis positive patients in the severely resource constrained regions of the world

Abstract Slides Poster

The motivation for this work is the primary need of screening Tuberculosis (TB) positive patients in the severely resource constrained regions of the world. Chest X-ray (CXR) is considered to be a promising indicator for the onset of TB, but the lack of skilled radiologists in such regions degrades the situation. Therefore, several computer aided diagnosis (CAD) systems have been proposed to solve the decision making problem, which includes hand engineered feature extraction methods to deep learning or Convolutional Neural Network (CNN) based methods. Feature extraction, being a time and resource intensive process, often delays the process of mass screening. Hence an end to end CNN architecture is proposed in this work to solve the problem. Two benchmark CXR datasets have been used in this work, collected from Shenzhen (China) and Montgomery County (USA), on which the proposed methodology achieved a maximum abnormality detection accuracy (ACC) of 91.7\% (0.96 AUC) and 87.47\% (0.92 AUC) respectively. To the greatest of our knowledge, the obtained results are marginally superior to the state of the art results that have solely used deep learning methodologies on the aforementioned datasets.

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Automatic Tuberculosis Detection Using Chest X-Ray Analysis with Position Enhanced Structural Information

Hermann Jepdjio Nkouanga, Szilard Vajda

Auto-TLDR; Automatic Chest X-ray Screening for Tuberculosis in Rural Population using Localized Region on Interest

Abstract Slides Poster Similar

For Tuberculosis (TB) detection beside the more expensive diagnosis solutions such as culture or sputum smear analysis one could consider the automatic analysis of the chest X-ray (CXR). This could mimic the lung region reading by the radiologist and it could provide a cheap solution to analyze and diagnose pulmonary abnormalities such as TB which often co- occurs with HIV. This software based pulmonary screening can be a reliable and affordable solution for rural population in different parts of the world such as India, Africa, etc. Our fully automatic system is processing the incoming CXR image by applying image processing techniques to detect the region on interest (ROI) followed by a computationally cheap feature extraction involving edge detection using Laplacian of Gaussian which we enrich by counting the local distribution of the intensities. The choice to ”zoom in” the ROI and look for abnormalities locally is motivated by the fact that some pulmonary abnormalities are localized in specific regions of the lungs. Later on the classifiers can decide about the normal or abnormal nature of each lung X-ray. Our goal is to find a simple feature, instead of a combination of several ones, -proposed and promoted in recent years’ literature, which can properly describe the different pathological alterations in the lungs. Our experiments report results on two publicly available data collections1, namely the Shenzhen and the Montgomery collection. For performance evaluation, measures such as area under the curve (AUC), and accuracy (ACC) were considered, achieving AUC = 0.81 (ACC = 83.33%) and AUC = 0.96 (ACC = 96.35%) for the Montgomery and Schenzen collections, respectively. Several comparisons are also provided to other state- of-the-art systems reported recently in the field.

Dealing with Scarce Labelled Data: Semi-Supervised Deep Learning with Mix Match for Covid-19 Detection Using Chest X-Ray Images

Saúl Calderón Ramirez, Raghvendra Giri, Shengxiang Yang, Armaghan Moemeni, Mario Umaña, David Elizondo, Jordina Torrents-Barrena, Miguel A. Molina-Cabello

Auto-TLDR; Semi-supervised Deep Learning for Covid-19 Detection using Chest X-rays

Abstract Slides Poster Similar

Coronavirus (Covid-19) is spreading fast, infecting people through contact in various forms including droplets from sneezing and coughing. Therefore, the detection of infected subjects in an early, quick and cheap manner is urgent. Currently available tests are scarce and limited to people in danger of serious illness. The application of deep learning to chest X-ray images for Covid-19 detection is an attractive approach. However, this technology usually relies on the availability of large labelled datasets, a requirement hard to meet in the context of a virus outbreak. To overcome this challenge, a semi-supervised deep learning model using both labelled and unlabelled data is proposed. We developed and tested a semi-supervised deep learning framework based on the Mix Match architecture to classify chest X-rays into Covid-19, pneumonia and healthy cases. The presented approach was calibrated using two publicly available datasets. The results show an accuracy increase of around $15\%$ under low labelled / unlabelled data ratio. This indicates that our semi-supervised framework can help improve performance levels towards Covid-19 detection when the amount of high-quality labelled data is scarce. Also, we introduce a semi-supervised deep learning boost coefficient which is meant to ease the scalability of our approach and performance comparison.

Unsupervised Detection of Pulmonary Opacities for Computer-Aided Diagnosis of COVID-19 on CT Images

Rui Xu, Xiao Cao, Yufeng Wang, Yen-Wei Chen, Xinchen Ye, Lin Lin, Wenchao Zhu, Chao Chen, Fangyi Xu, Yong Zhou, Hongjie Hu, Shoji Kido, Noriyuki Tomiyama

Auto-TLDR; A computer-aided diagnosis of COVID-19 from CT images using unsupervised pulmonary opacity detection

Abstract Slides Poster Similar

COVID-19 emerged towards the end of 2019 which was identified as a global pandemic by the world heath organization (WHO). With the rapid spread of COVID-19, the number of infected and suspected patients has increased dramatically. Chest computed tomography (CT) has been recognized as an efficient tool for the diagnosis of COVID-19. However, the huge CT data make it difficult for radiologist to fully exploit them on the diagnosis. In this paper, we propose a computer-aided diagnosis system that can automatically analyze CT images to distinguish the COVID-19 against to community-acquired pneumonia (CAP). The proposed system is based on an unsupervised pulmonary opacity detection method that locates opacity regions by a detector unsupervisedly trained from CT images with normal lung tissues. Radiomics based features are extracted insides the opacity regions, and fed into classifiers for classification. We evaluate the proposed CAD system by using 200 CT images collected from different patients in several hospitals. The accuracy, precision, recall, f1-score and AUC achieved are 95.5%, 100%, 91%, 95.1% and 95.9% respectively, exhibiting the promising capacity on the differential diagnosis of COVID-19 from CT images.

Fine-Tuning Convolutional Neural Networks: A Comprehensive Guide and Benchmark Analysis for Glaucoma Screening

Amed Mvoulana, Rostom Kachouri, Mohamed Akil

Auto-TLDR; Fine-tuning Convolutional Neural Networks for Glaucoma Screening

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This work aimed at giving a comprehensive and in-detailed guide on the route to fine-tuning Convolutional Neural Networks (CNNs) for glaucoma screening. Transfer learning consists in a promising alternative to train CNNs from stratch, to avoid the huge data and resources requirements. After a thorough study of five state-of-the-art CNNs architectures, a complete and well-explained strategy for fine-tuning these networks is proposed, using hyperparameter grid-searching and two-phase training approach. Excellent performance is reached on model evaluation, with a 0.9772 AUROC validation rate, giving arise to reliable glaucoma diagosis-help systems. Also, a benchmark analysis is conducted across all fine-tuned models, studying them according to performance indices such as model complexity and size, AUROC density and inference time. This in-depth analysis allows a rigorous comparison between model characteristics, and is useful for giving practioners important trademarks for prospective applications and deployments.

Dual Encoder Fusion U-Net (DEFU-Net) for Cross-manufacturer Chest X-Ray Segmentation

Zhang Lipei, Aozhi Liu, Jing Xiao

Auto-TLDR; Inception Convolutional Neural Network with Dilation for Chest X-Ray Segmentation

Abstract Slides Similar

A number of methods based on the deep learning have been applied to medical image segmentation and have achieved state-of-the-art performance. The most famous technique is U-Net which has been used to many medical datasets including the Chest X-ray. Due to the importance of chest x- ray data in studying COVID-19, there is a demand for state-of- art models capable of precisely segmenting chest x-rays. In this paper, we propose a dual encoder fusion U-Net framework for Chest X-rays based on Inception Convolutional Neural Network with dilation, Densely Connected Recurrent Convolutional Neural Network, which is named DEFU-Net. The densely connected recurrent path extends the network deeper for facilitating context feature extraction. In order to increase the width of network and enrich representation of features, the inception blocks with dilation have been used. The inception blocks can capture globally and locally spatial information with various receptive fields to avoid information loss caused by max-pooling. Meanwhile, the features fusion of two path by summation preserve the context and the spatial information for decoding part. We applied this model in Chest X-ray dataset from two different manufacturers (Montgomery and Shenzhen hospital). The DEFU-Net achieves the better performance than basic U-Net, residual U-Net, BCDU- Net, R2U-Net and attention R2U-Net. This model approaches state-of-the-art in this mixed dataset. The open source code for this proposed framework is public available.

Documents Counterfeit Detection through a Deep Learning Approach

Darwin Danilo Saire Pilco, Salvatore Tabbone

Auto-TLDR; End-to-End Learning for Counterfeit Documents Detection using Deep Neural Network

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The main topic of this work is on the detection of counterfeit documents and especially banknotes. We propose an end-to-end learning model using a deep learning approach based on Adapnet++ which manages feature extraction at multiple scale levels using several residual units. Unlike previous models based on regions of interest (ROI) and high-resolution documents, our network is feed with simple input images (i.e., a single patch) and we do not need high resolution images. Besides, discriminative regions can be visualized at different scales. Our network learns by itself which regions of interest predict the better results. Experimental results show that we are competitive compared with the state-of-the-art and our deep neural network has good ability to generalize and can be applied to other kind of documents like identity or administrative one.

A Comparison of Neural Network Approaches for Melanoma Classification

Maria Frasca, Michele Nappi, Michele Risi, Genoveffa Tortora, Alessia Auriemma Citarella

Auto-TLDR; Classification of Melanoma Using Deep Neural Network Methodologies

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Melanoma is the deadliest form of skin cancer and it is diagnosed mainly visually, starting from initial clinical screening and followed by dermoscopic analysis, biopsy and histopathological examination. A dermatologist’s recognition of melanoma may be subject to errors and may take some time to diagnose it. In this regard, deep learning can be useful in the study and classification of skin cancer. In particular, by classifying images with Deep Neural Network methodologies, it is possible to obtain comparable or even superior results compared to those of dermatologists. In this paper, we propose a methodology for the classification of melanoma by adopting different deep learning techniques applied to a common dataset, composed of images from the ISIC dataset and consisting of different types of skin diseases, including melanoma on which we applied a specific pre-processing phase. In particular, a comparison of the results is performed in order to select the best effective neural network to be applied to the problem of recognition and classification of melanoma. Moreover, we also evaluate the impact of the pre- processing phase on the final classification. Different metrics such as accuracy, sensitivity, and specificity have been selected to assess the goodness of the adopted neural networks and compare them also with the manual classification of dermatologists.

Influence of Event Duration on Automatic Wheeze Classification

Bruno M Rocha, Diogo Pessoa, Alda Marques, Paulo Carvalho, Rui Pedro Paiva

Auto-TLDR; Experimental Design of the Non-wheeze Class for Wheeze Classification

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Patients with respiratory conditions typically exhibit adventitious respiratory sounds, such as wheezes. Wheeze events have variable duration. In this work we studied the influence of event duration on wheeze classification, namely how the creation of the non-wheeze class affected the classifiers' performance. First, we evaluated several classifiers on an open access respiratory sound database, with the best one reaching sensitivity and specificity values of 98% and 95%, respectively. Then, by changing one parameter in the design of the non-wheeze class, i.e., event duration, the best classifier only reached sensitivity and specificity values of 53% and 75%, respectively. These results demonstrate the importance of experimental design on the assessment of wheeze classification algorithms' performance.

Bridging the Gap between Natural and Medical Images through Deep Colorization

Lia Morra, Luca Piano, Fabrizio Lamberti, Tatiana Tommasi

Auto-TLDR; Transfer Learning for Diagnosis on X-ray Images Using Color Adaptation

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Deep learning has thrived by training on large-scale datasets. However, in many applications, as for medical image diagnosis, getting massive amount of data is still prohibitive due to privacy, lack of acquisition homogeneity and annotation cost. In this scenario transfer learning from natural image collections is a standard practice that attempts to tackle shape, texture and color discrepancy all at once through pretrained model fine-tuning. In this work we propose to disentangle those challenges and design a dedicated network module that focuses on color adaptation. We combine learning from scratch of the color module with transfer learning of different classification backbones obtaining an end-to-end, easy-to-train architecture for diagnostic image recognition on X-ray images. Extensive experiments show how our approach is particularly efficient in case of data scarcity and provides a new path for further transferring the learned color information across multiple medical datasets.

A Systematic Investigation on Deep Architectures for Automatic Skin Lesions Classification

Pierluigi Carcagni, Marco Leo, Andrea Cuna, Giuseppe Celeste, Cosimo Distante

Auto-TLDR; RegNet: Deep Investigation of Convolutional Neural Networks for Automatic Classification of Skin Lesions

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Computer vision-based techniques are more and more employed in healthcare and medical fields nowadays in order, principally, to be as a support to the experienced medical staff to help them to make a quick and correct diagnosis. One of the hot topics in this arena concerns the automatic classification of skin lesions. Several promising works exist about it, mainly leveraging Convolutional Neural Networks (CNN), but proposed pipeline mainly rely on complex data preprocessing and there is no systematic investigation about how available deep models can actually reach the accuracy needed for real applications. In order to overcome these drawbacks, in this work, an end-to-end pipeline is introduced and some of the most recent Convolutional Neural Networks (CNNs) architectures are included in it and compared on the largest common benchmark dataset recently introduced. To this aim, for the first time in this application context, a new network design paradigm, namely RegNet, has been exploited to get the best models among a population of configurations. The paper introduces a threefold level of contribution and novelty with respect the previous literature: the deep investigation of several CNN architectures driving to a consistent improvement of the lesions recognition accuracy, the exploitation of a new network design paradigm able to study the behavior of populations of models and a deep discussion about pro and cons of each analyzed method paving the path towards new research lines.

Multi-Scale and Attention Based ResNet for Heartbeat Classification

Haojie Zhang, Gongping Yang, Yuwen Huang, Feng Yuan, Yilong Yin

Auto-TLDR; A Multi-Scale and Attention based ResNet for ECG heartbeat classification in intra-patient and inter-patient paradigms

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This paper presents a novel deep learning framework for the electrocardiogram (ECG) heartbeat classification. Although there have been some studies with excellent overall accuracy, these studies have not been very accurate in the diagnosis of arrhythmia classes especially such as supraventricular ectopic beat (SVEB) and ventricular ectopic beat (VEB). In our work, we propose a Multi-Scale and Attention based ResNet for heartbeat classification in intra-patient and inter-patient paradigms respectively. Firstly, we extract shallow features from a convolutional layer. Secondly, the shallow features are sent into three branches with different convolution kernels in order to combine receptive fields of different sizes. Finally, fully connected layers are used to classify the heartbeat. Besides, we design a new attention mechanism based on the characteristics of heartbeat data. At last, extensive experiments on benchmark dataset demonstrate the effectiveness of our proposed model.

Robust Localization of Retinal Lesions Via Weakly-Supervised Learning

Ruohan Zhao, Qin Li, Jane You

Auto-TLDR; Weakly Learning of Lesions in Fundus Images Using Multi-level Feature Maps and Classification Score

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Retinal fundus images reveal the condition of retina, blood vessels and optic nerve. Retinal imaging is becoming widely adopted in clinical work because any subtle changes to the structures at the back of the eyes can affect the eyes and indicate the overall health. Machine learning, in particular deep learning by convolutional neural network (CNN), has been increasingly adopted for computer-aided detection (CAD) of retinal lesions. However, a significant barrier to the high performance of CNN based CAD approach is caused by the lack of sufficient labeled ground-truth image samples for training. Unlike the fully-supervised learning which relies on pixel-level annotation of pathology in fundus images, this paper presents a new approach to discriminate the location of various lesions based on image-level labels via weakly learning. More specifically, our proposed method leverages multi-level feature maps and classification score to cope with both bright and red lesions in fundus images. To enhance capability of learning less discriminative parts of objects (e.g. small blobs of microaneurysms opposed to bulk of exudates), the classifier is regularized by refining images with corresponding labels. The experimental results of the performance evaluation and benchmarking at both image-level and pixel-level on the public DIARETDB1 dataset demonstrate the feasibility and excellent potentials of our method in practice.

Prediction of Obstructive Coronary Artery Disease from Myocardial Perfusion Scintigraphy using Deep Neural Networks

Ida Arvidsson, Niels Christian Overgaard, Miguel Ochoa Figueroa, Jeronimo Rose, Anette Davidsson, Kalle Åström, Anders Heyden

Auto-TLDR; A Deep Learning Algorithm for Multi-label Classification of Myocardial Perfusion Scintigraphy for Stable Ischemic Heart Disease

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For diagnosis and risk assessment in patients with stable ischemic heart disease, myocardial perfusion scintigraphy is one of the most common cardiological examinations performed today. There are however many motivations for why an artificial intelligence algorithm would provide useful input to this task. For example to reduce the subjectiveness and save time for the nuclear medicine physicians working with this time consuming task. In this work we have developed a deep learning algorithm for multi-label classification based on a modified convolutional neural network to estimate probability of obstructive coronary artery disease in the left anterior artery, left circumflex artery and right coronary artery. The prediction is based on data from myocardial perfusion scintigraphy studies conducted in a dedicated Cadmium-Zinc-Telluride cardio camera (D-SPECT Spectrum Dynamics). Data from 588 patients was available, with stress images in both upright and supine position, as well as a number of auxiliary parameters such as angina symptoms and BMI. The data was used to train and evaluate the algorithm using 5-fold cross-validation. We achieve state-of-the-art results for this task with an area under the receiver operating characteristics curve of 0.89 as average on per-vessel level and 0.94 on per-patient level.

Dual Stream Network with Selective Optimization for Skin Disease Recognition in Consumer Grade Images

Krishnam Gupta, Jaiprasad Rampure, Monu Krishnan, Ajit Narayanan, Nikhil Narayan

Auto-TLDR; A Deep Network Architecture for Skin Disease Localisation and Classification on Consumer Grade Images

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Skin disease localisation and classification on consumer-grade images is more challenging compared to that on dermoscopic imaging. Consumer grade images refer to the images taken using commonly available imaging devices such as a mobile camera or a hand held digital camera. Such images, in addition to having the skin condition of interest in a very small area of the image, has other noisy non-clinical details introduced due to the lighting conditions and the distance of the hand held device from the anatomy at the time of acquisition. We propose a novel deep network architecture \& a new optimization strategy for classification with implicit localisation of skin diseases from clinical/consumer grade images. A weakly supervised segmentation algorithm is first employed to extract Region of Interests (RoI) from the image, the RoI and the original image form the two input streams of the proposed architecture. Each stream of the architecture learns high level and low level features from the original image and the RoI, respectively. The two streams are independently optimised until the loss stops decreasing after which both the streams are optimised collectively with the help of a third combiner sub-network. Such a strategy resulted in a 5% increase of accuracy over the current state-of-the-art methods on SD-198 dataset, which is publicly available. The proposed algorithm is also validated on a new dataset containing over 12,000 images across 75 different skin conditions. We intend to release this dataset as SD-75 to aid in the advancement of research on skin condition classification on consumer grade images.

A Lumen Segmentation Method in Ureteroscopy Images Based on a Deep Residual U-Net Architecture

Jorge Lazo, Marzullo Aldo, Sara Moccia, Michele Catellani, Benoit Rosa, Elena De Momi, Michel De Mathelin, Francesco Calimeri

Auto-TLDR; A Deep Neural Network for Ureteroscopy with Residual Units

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Ureteroscopy is becoming the first surgical treatment option for the majority of urinary affections. This procedure is carried out using an endoscope which provides the surgeon with the visual and spatial information necessary to navigate inside the urinary tract. Having in mind the development of surgical assistance systems, that could enhance the performance of surgeon, the task of lumen segmentation is a fundamental part since this is the visual reference which marks the path that the endoscope should follow. This is something that has not been analyzed in ureteroscopy data before. However, this task presents several challenges given the image quality and the conditions itself of ureteroscopy procedures. In this paper, we study the implementation of a Deep Neural Network which exploits the advantage of residual units in an architecture based on U-Net. For the training of these networks, we analyze the use of two different color spaces: gray-scale and RGB data images. We found that training on gray-scale images gives the best results obtaining mean values of Dice Score, Precision, and Recall of 0.73, 0.58, and 0.92 respectively. The results obtained show that the use of residual U-Net could be a suitable model for further development for a computer-aided system for navigation and guidance through the urinary system.

Automatic Semantic Segmentation of Structural Elements related to the Spinal Cord in the Lumbar Region by Using Convolutional Neural Networks

Jhon Jairo Sáenz Gamboa, Maria De La Iglesia-Vaya, Jon Ander Gómez

Auto-TLDR; Semantic Segmentation of Lumbar Spine Using Convolutional Neural Networks

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This work addresses the problem of automatically segmenting the MR images corresponding to the lumbar spine. The purpose is to detect and delimit the different structural elements like vertebrae, intervertebral discs, nerves, blood vessels, etc. This task is known as semantic segmentation. The approach proposed in this work is based on convolutional neural networks whose output is a mask where each pixel from the input image is classified into one of the possible classes. Classes were defined by radiologists and correspond to structural elements and tissues. The proposed network architectures are variants of the U-Net. Several complementary blocks were used to define the variants: spatial attention models, deep supervision and multi-kernels at input, this last block type is based on the idea of inception. Those architectures which got the best results are described in this paper, and their results are discussed. Two of the proposed architectures outperform the standard U-Net used as baseline.

MTGAN: Mask and Texture-Driven Generative Adversarial Network for Lung Nodule Segmentation

Wei Chen, Qiuli Wang, Kun Wang, Dan Yang, Xiaohong Zhang, Chen Liu, Yucong Li

Auto-TLDR; Mask and Texture-driven Generative Adversarial Network for Lung Nodule Segmentation

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Accurate segmentation for lung nodules in lung computed tomography (CT) scans plays a key role in the early diagnosis of lung cancer. Many existing methods, especially UNet, have made significant progress in lung nodule segmentation. However, due to the complex shapes of lung nodules and the similarity of visual characteristics between nodules and lung tissues, an accurate segmentation with few false positives of lung nodules is still a challenging problem. Considering the fact that both boundary and texture information of lung nodules are important for obtaining an accurate segmentation result, we propose a novel Mask and Texture-driven Generative Adversarial Network (MTGAN) with a joint multi-scale L1 loss for lung nodule segmentation, which takes full advantages of U-Net and adversarial training. The proposed MTGAN leverages adversarial learning strategy guided by the boundary and texture information of lung nodules to generate more accurate segmentation results with lesser false positives. We validate our model with the LIDC–IDRI dataset, and experimental results show that our method achieves excellent segmentation results for a variety of lung nodules, especially for juxtapleural nodules and low-dense nodules. Without any bells and whistles, the proposed MTGAN achieves significant segmentation performance with the Dice similarity coefficient (DSC) of 85.24% on the LIDC–IDRI dataset.

Deep Transfer Learning for Alzheimer’s Disease Detection

Nicole Cilia, Claudio De Stefano, Francesco Fontanella, Claudio Marrocco, Mario Molinara, Alessandra Scotto Di Freca

Auto-TLDR; Automatic Detection of Handwriting Alterations for Alzheimer's Disease Diagnosis using Dynamic Features

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Early detection of Alzheimer’s Disease (AD) is essential in order to initiate therapies that can reduce the effects of such a disease, improving both life quality and life expectancy of patients. Among all the activities carried out in our daily life, handwriting seems one of the first to be influenced by the arise of neurodegenerative diseases. For this reason, the analysis of handwriting and the study of its alterations has become of great interest in this research field in order to make a diagnosis as early as possible. In recent years, many studies have tried to use classification algorithms applied to handwritings to implement decision support systems for AD diagnosis. A key issue for the use of these techniques is the detection of effective features, that allow the system to distinguish the natural handwriting alterations due to age, from those caused by neurodegenerative disorders. In this context, many interesting results have been published in the literature in which the features have been typically selected by hand, generally considering the dynamics of the handwriting process in order to detect motor disorders closely related to AD. Features directly derived from handwriting generation models can be also very helpful for AD diagnosis. It should be remarked, however, that the above features do not consider changes in the shape of handwritten traces, which may occur as a consequence of neurodegenerative diseases, as well as the correlation among shape alterations and changes in the dynamics of the handwriting process. Moving from these considerations, the aim of this study is to verify if the combined use of both shape and dynamic features allows a decision support system to improve performance for AD diagnosis. To this purpose, starting from a database of on-line handwriting samples, we generated for each of them a synthetic off-line colour image, where the colour of each elementary trait encodes, in the three RGB channels, the dynamic information associated to that trait. Finally, we exploited the capability of Deep Neural Networks (DNN) to automatically extract features from raw images. The experimental comparison of the results obtained by using standard features and features extracted according the above procedure, confirmed the effectiveness of our approach.

Using Machine Learning to Refer Patients with Chronic Kidney Disease to Secondary Care

Lee Au-Yeung, Xianghua Xie, Timothy Marcus Scale, James Anthony Chess

Auto-TLDR; A Machine Learning Approach for Chronic Kidney Disease Prediction using Blood Test Data

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There has been growing interest recently in using machine learning techniques as an aid in clinical medicine. Machine learning offers a range of classification algorithms which can be applied to medical data to aid in making clinical predictions. Recent studies have demonstrated the high predictive accuracy of various classification algorithms applied to clinical data. Several studies have already been conducted in diagnosing or predicting chronic kidney disease at various stages using different sets of variables. In this study we are investigating the use machine learning techniques with blood test data. Such a system could aid renal teams in making recommendations to primary care general practitioners to refer patients to secondary care where patients may benefit from earlier specialist assessment and medical intervention. We are able to achieve an overall accuracy of 88.48\% using logistic regression, 87.12\% using ANN and 85.29\% using SVM. ANNs performed with the highest sensitivity at 89.74\% compared to 86.67\% for logistic regression and 85.51\% for SVM.

End-To-End Training of a Two-Stage Neural Network for Defect Detection

Jakob Božič, Domen Tabernik, Danijel Skocaj

Auto-TLDR; End-to-End Training of Segmentation-based Neural Network for Surface Defect Detection

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Segmentation-based, two-stage neural network has shown excellent results in the surface defect detection, enabling the network to learn from a relatively small number of samples. In this work, we introduce end-to-end training of the two-stage network together with several extensions to the training process, which reduce the amount of training time and improve results on surface defect detection tasks. To enable end-to-end training we carefully balance the contributions of both the segmentation and the classification loss throughout the learning. We adjust the gradient flow from the classification into the segmentation network in order to prevent the unstable features from corrupting the learning. As additional extension to the learning, we propose frequency-of-use sampling scheme of negative samples to address the issue of over- and under-sampling of images during the training, while we employ the distance transform algorithm on the region-based segmentation masks as weights for positive pixels, giving greater importance to areas with higher probability of presence of defect without requiring a detailed annotation. We demonstrate the performance of the end-to-end training scheme and the proposed extensions on three defect detection datasets---DAGM, KolektorSDD and Severstal Steel defect dataset--- where we show state-of-the-art results. On the DAGM and the KolektorSDD we demonstrate 100\% detection rate, therefore completely solving the datasets. Additional ablation study performed on all three datasets quantitatively demonstrates the contribution to the overall result improvements for each of the proposed extensions.

End-To-End Multi-Task Learning for Lung Nodule Segmentation and Diagnosis

Wei Chen, Qiuli Wang, Dan Yang, Xiaohong Zhang, Chen Liu, Yucong Li

Auto-TLDR; A novel multi-task framework for lung nodule diagnosis based on deep learning and medical features

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Computer-Aided Diagnosis (CAD) systems for lung nodule diagnosis based on deep learning have attracted much attention in recent years. However, most existing methods ignore the relationships between the segmentation and classification tasks, which leads to unstable performances. To address this problem, we propose a novel multi-task framework, which can provide lung nodule segmentation mask, malignancy prediction, and medical features for interpretable diagnosis at the same time. Our framework mainly contains two sub-network: (1) Multi-Channel Segmentation Sub-network (MSN) for lung nodule segmentation, and (2) Joint Classification Sub-network (JCN) for interpretable lung nodule diagnosis. In the proposed framework, we use U-Net down-sampling processes for extracting low-level deep learning features, which are shared by two sub-networks. The JCN forces the down-sampling processes to learn better lowlevel deep features, which lead to a better construct of segmentation masks. Meanwhile, two additional channels constructed by OTSU and super-pixel (SLIC) methods, are utilized as the guideline of the feature extraction. The proposed framework takes advantages of deep learning methods and classical methods, which can significantly improve the performances of all tasks. We evaluate the proposed framework on public dataset LIDCIDRI. Our framework achieves a promising Dice score of 86.43% in segmentation, 87.07% in malignancy level prediction, and convincing results in interpretable medical feature predictions.

Planar 3D Transfer Learning for End to End Unimodal MRI Unbalanced Data Segmentation

Martin Kolarik, Radim Burget, Carlos M. Travieso-Gonzalez, Jan Kocica

Auto-TLDR; Planar 3D Res-U-Net Network for Unbalanced 3D Image Segmentation using Fluid Attenuation Inversion Recover

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We present a novel approach of 2D to 3D transfer learning based on mapping pre-trained 2D convolutional neural network weights into planar 3D kernels. The method is validated by proposed planar 3D res-u-net network with encoder transferred from the 2D VGG-16 which is applied for a single-stage unbalanced 3D image data segmentation. In particular, we evaluate the method on the MICCAI 2016 MS lesion segmentation challenge dataset utilizing solely Fluid Attenuation Inversion Recover (FLAIR) sequence without brain extraction for training and inference to simulate real medical praxis. The planar 3D res-u-net network performed the best both in sensitivity and Dice score amongst end to end methods processing raw MRI scans and achieved comparable Dice score to a state-of-the-art unimodal not end to end approach. Complete source code was released under the open-source license and this paper is in compliance with the Machine learning Reproducibility Checklist. By implementing practical transfer learning for 3D data representation we were able to successfully segment heavily unbalanced data without selective sampling and achieved more reliable results using less training data in single modality. From medical perspective, the unimodal approach gives an advantage in real praxis as it does not require co-registration nor additional scanning time during examination. Although modern medical imaging methods capture high resolution 3D anatomy scans suitable for computer aided detection system processing, deployment of automatic systems for interpretation of radiology imaging is still rather theoretical in many medical areas. Our work aims to bridge the gap offering solution for partial research questions.

A Deep Learning Approach for the Segmentation of Myocardial Diseases

Khawala Brahim, Abdull Qayyum, Alain Lalande, Arnaud Boucher, Anis Sakly, Fabrice Meriaudeau

Auto-TLDR; Segmentation of Myocardium Infarction Using Late GADEMRI and SegU-Net

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Cardiac left ventricular (LV) segmentation is of paramount essential step for both diagnosis and treatment of cardiac pathologies such as ischemia, myocardial infarction, arrhythmia and myocarditis. However, this segmentation is challenging due to high variability across patients and the potential lack of contrast between structures. In this work, we propose and evaluate a (2.5D) SegU-Net model based on the fusion of two deep learning techniques (U-Net and Seg-Net) for automated LGEMRI (Late gadolinium enhanced magnetic resonance imaging) myocardial disease (infarct core and no reflow region) quantification in a new multifield expert annotated dataset. Given that the scar tissue represents a small part of the whole MRI slices, we focused on myocardium area. Segmentation results show that this preprocessing step facilitate the learning procedure. In order to solve the class imbalance problem, we propose to apply the Jaccard loss and the Focal Loss as optimization loss function and to integrate a class weights strategy into the objective function. Late combination has been used to merge the output of the best trained models on a different set of hyperparameters. The final network segmentation performances will be useful for future comparison of new method to the current related work for this task. A total number of 2237 of slices (320 cases) were used for training/validation and 210 slices (35 cases) were used for testing. Experiments over our proposed dataset, using several evaluation metrics such Jaccard distance (IOU), Accuracy and Dice similarity coefficient (DSC), demonstrate efficiency performance in quantifying different zones of myocardium infarction across various patients. As compared to the second intra-observer study, our testing results showed that the SegUNet prediction model leads to these average dice coefficients over all segmented tissue classes, respectively : 'Background': 0.99999, 'Myocardium': 0.99434, 'Infarctus': 0.95587, 'Noreflow': 0.78187.

Investigating and Exploiting Image Resolution for Transfer Learning-Based Skin Lesion Classification

Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Rupert Ecker, Georg Dorffner, Isabella Ellinger

Auto-TLDR; Fine-tuned Neural Networks for Skin Lesion Classification Using Dermoscopic Images

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Skin cancer is among the most common cancer types. Dermoscopic image analysis improves the diagnostic accuracy for detection of malignant melanoma and other pigmented skin lesions when compared to unaided visual inspection. Hence, computer-based methods to support medical experts in the diagnostic procedure are of great interest. Fine-tuning pre-trained convolutional neural networks (CNNs) has been shown to work well for skin lesion classification. Pre-trained CNNs are usually trained with natural images of a fixed image size which is typically significantly smaller than captured skin lesion images and consequently dermoscopic images are downsampled for fine-tuning. However, useful medical information may be lost during this transformation. In this paper, we explore the effect of input image size on skin lesion classification performance of fine-tuned CNNs. For this, we resize dermoscopic images to different resolutions, ranging from 64x64 to 768x768 pixels and investigate the resulting classification performance of three well-established CNNs, namely DenseNet-121, ResNet-18, and ResNet-50. Our results show that using very small images (of size 64x64 pixels) degrades the classification performance, while images of size 128x128 pixels and above support good performance with larger image sizes leading to slightly improved classification. We further propose a novel fusion approach based on a three-level ensemble strategy that exploits multiple fine-tuned networks trained with dermoscopic images at various sizes. When applied on the ISIC 2017 skin lesion classification challenge, our fusion approach yields an area under the receiver operating characteristic curve of 89.2% and 96.6% for melanoma classification and seborrheic keratosis classification, respectively, outperforming state-of-the-art algorithms.

A Benchmark Dataset for Segmenting Liver, Vasculature and Lesions from Large-Scale Computed Tomography Data

Bo Wang, Zhengqing Xu, Wei Xu, Qingsen Yan, Liang Zhang, Zheng You

Auto-TLDR; The Biggest Treatment-Oriented Liver Cancer Dataset for Segmentation

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How to build a high-performance liver-related computer assisted diagnosis system is an open question of great interest. However, the performance of the state-of-art algorithm is always limited by the amount of data and quality of the label. To address this problem, we propose the biggest treatment-oriented liver cancer dataset for liver surgery and treatment planning. This dataset provides 216 cases (totally about 268K frames) scanned images in contrast-enhanced computed tomography (CT). We labeled all the CT images with the liver, liver vasculature and liver tumor segmentation ground truth for train and tune segmentation algorithms in advance. Based on that, we evaluate several recent and state-of-the-art segmentation algorithms, including 7 deep learning methods, on CT sequences. All results are compared to reference segmentations five error metrics that highlight different aspects of segmentation accuracy. In general, compared with previous datasets, our dataset is really a challenging dataset. To our knowledge, the proposed dataset and benchmark allow for the first time systematic exploration of such issues, and will be made available to allow for further research in this field.

Explainable Feature Embedding Using Convolutional Neural Networks for Pathological Image Analysis

Kazuki Uehara, Masahiro Murakawa, Hirokazu Nosato, Hidenori Sakanashi

Auto-TLDR; Explainable Diagnosis Using Convolutional Neural Networks for Pathological Image Analysis

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The development of computer-assisted diagnosis (CAD) algorithms for pathological image analysis constitutes an important research topic. Recently, convolutional neural networks (CNNs) have been used in several studies for the development of CAD algorithms. Such systems are required to be not only accurate but also explainable for their decisions, to ensure reliability. However, a limitation of using CNNs is that the basis of the decisions made by them are incomprehensible to humans. Thus, in this paper, we present an explainable diagnosis method, which comprises of two CNNs for different rolls. This method allows us to interpret the basis of the decisions made by CNN from two perspectives, namely statistics and visualization. For the statistical explanation, the method constructs a dictionary of representative pathological features. It performs diagnoses based on the occurrence and importance of learned features referred from its dictionary. To construct the dictionary, we introduce a vector quantization scheme for CNN. For the visual interpretation, the method provides images of learned features embedded in a high-dimensional feature space as an index of the dictionary by generating them using a conditional autoregressive model. The experimental results showed that the proposed network learned pathological features, which contributed to the diagnosis and yielded an area under the receiver operating curve (AUC) of approximately 0.93 for detecting atypical tissues in pathological images of the uterine cervix. Moreover, the proposed method demonstrated that it could provide visually interpretable images to show the rationales behind its decisions. Thus, the proposed method can serve as a valuable tool for pathological image analysis in terms of both its accuracy and explainability.

Early Wildfire Smoke Detection in Videos

Taanya Gupta, Hengyue Liu, Bir Bhanu

Auto-TLDR; Semi-supervised Spatio-Temporal Video Object Segmentation for Automatic Detection of Smoke in Videos during Forest Fire

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Recent advances in unmanned aerial vehicles and camera technology have proven useful for the detection of smoke that emerges above the trees during a forest fire. Automatic detection of smoke in videos is of great interest to Fire department. To date, in most parts of the world, the fire is not detected in its early stage and generally it turns catastrophic. This paper introduces a novel technique that integrates spatial and temporal features in a deep learning framework using semi-supervised spatio-temporal video object segmentation and dense optical flow. However, detecting this smoke in the presence of haze and without the labeled data is difficult. Considering the visibility of haze in the sky, a dark channel pre-processing method is used that reduces the amount of haze in video frames and consequently improves the detection results. Online training is performed on a video at the time of testing that reduces the need for ground-truth data. Tests using the publicly available video datasets show that the proposed algorithms outperform previous work and they are robust across different wildfire-threatened locations.

BG-Net: Boundary-Guided Network for Lung Segmentation on Clinical CT Images

Rui Xu, Yi Wang, Tiantian Liu, Xinchen Ye, Lin Lin, Yen-Wei Chen, Shoji Kido, Noriyuki Tomiyama

Auto-TLDR; Boundary-Guided Network for Lung Segmentation on CT Images

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Lung segmentation on CT images is a crucial step for a computer-aided diagnosis system of lung diseases. The existing deep learning based lung segmentation methods are less efficient to segment lungs on clinical CT images, especially that the segmentation on lung boundaries is not accurate enough due to complex pulmonary opacities in practical clinics. In this paper, we propose a boundary-guided network (BG-Net) to address this problem. It contains two auxiliary branches that separately segment lungs and extract the lung boundaries, and an aggregation branch that efficiently exploits lung boundary cues to guide the network for more accurate lung segmentation on clinical CT images. We evaluate the proposed method on a private dataset collected from the Osaka university hospital and four public datasets including StructSeg, HUG, VESSEL12, and a Novel Coronavirus 2019 (COVID-19) dataset. Experimental results show that the proposed method can segment lungs more accurately and outperform several other deep learning based methods.

Deep Learning in the Ultrasound Evaluation of Neonatal Respiratory Status

Michela Gravina, Diego Gragnaniello, Giovanni Poggi, Luisa Verdoliva, Carlo Sansone, Iuri Corsini, Carlo Dani, Fabio Meneghin, Gianluca Lista, Salvatore Aversa, Migliaro Migliaro, Raimondi Francesco

Auto-TLDR; Lung Ultrasound Imaging with Deep Learning Networks and Training Strategies: An Analysis and Adaptation

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Lung ultrasound imaging is reaching growing interest from the scientific community. On one side, thanks to its harmlessness and high descriptive power, this kind of diagnostic imaging became largely adopted in sensitive applications, like the diagnosis and follow-up of preterm newborns in neonatal intensive care units. At the same time, novel image analysis and pattern recognition approaches can fully exploit the rich information contained in this data, making them attractive for the research community. In this work, we present a thorough analysis of recent deep learning networks and training strategies conducted on a vast and challenging multicenter dataset comprising 87 patients with different diseases and gestational ages. These approaches are firstly discussed in the context of lung respiratory status assessing through ultrasound imaging and then evaluated against a reference marker. The conducted analysis shed some light on this problem, by relating the criticisms that can mislead the training procedure and proposing some adaptations to the specific problem. The achieved results sensibly outperform that obtained by previous work, based on textural features, and narrow the gap with the visual score predicted by the human experts.

Confidence Calibration for Deep Renal Biopsy Immunofluorescence Image Classification

Federico Pollastri, Juan Maroñas, Federico Bolelli, Giulia Ligabue, Roberto Paredes, Riccardo Magistroni, Costantino Grana

Auto-TLDR; A Probabilistic Convolutional Neural Network for Immunofluorescence Classification in Renal Biopsy

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With this work we tackle immunofluorescence classification in renal biopsy, employing state-of-the-art Convolutional Neural Networks. In this setting, the aim of the probabilistic model is to assist an expert practitioner towards identifying the location pattern of antibody deposits within a glomerulus. Since modern neural networks often provide overconfident outputs, we stress the importance of having a reliable prediction, demonstrating that Temperature Scaling, a recently introduced re-calibration technique, can be successfully applied to immunofluorescence classification in renal biopsy. Experimental results demonstrate that the designed model yields good accuracy on the specific task, and that Temperature Scaling is able to provide reliable probabilities, which are highly valuable for such a task given the low inter-rater agreement.

BAT Optimized CNN Model Identifies Water Stress in Chickpea Plant Shoot Images

Shiva Azimi, Taranjit Kaur, Tapan Gandhi

Auto-TLDR; BAT Optimized ResNet-18 for Stress Classification of chickpea shoot images under water deficiency

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Stress due to water deficiency in plants can significantly lower the agricultural yield. It can affect many visible plant traits such as size and surface area, the number of leaves and their color, etc. In recent years, computer vision-based plant phenomics has emerged as a promising tool for plant research and management. Such techniques have the advantage of being non-destructive, non-evasive, fast, and offer high levels of automation. Pulses like chickpeas play an important role in ensuring food security in poor countries owing to their high protein and nutrition content. In the present work, we have built a dataset comprising of two varieties of chickpea plant shoot images under different moisture stress conditions. Specifically, we propose a BAT optimized ResNet-18 model for classifying stress induced by water deficiency using chickpea shoot images. BAT algorithm identifies the optimal value of the mini-batch size to be used for training rather than employing the traditional manual approach of trial and error. Experimentation on two crop varieties (JG and Pusa) reveals that BAT optimized approach achieves an accuracy of 96% and 91% for JG and Pusa varieties that is better than the traditional method by 4%. The experimental results are also compared with state of the art CNN models like Alexnet, GoogleNet, and ResNet-50. The comparison results demonstrate that the proposed BAT optimized ResNet-18 model achieves higher performance than the comparison counterparts.

AdaFilter: Adaptive Filter Design with Local Image Basis Decomposition for Optimizing Image Recognition Preprocessing

Aiga Suzuki, Keiichi Ito, Takahide Ibe, Nobuyuki Otsu

Auto-TLDR; Optimal Preprocessing Filtering for Pattern Recognition Using Higher-Order Local Auto-Correlation

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Image preprocessing is an important process during pattern recognition which increases the recognition performance. Linear convolution filtering is a primary preprocessing method used to enhance particular local patterns of the image which are essential for recognizing the images. However, because of the vast search space of the preprocessing filter, almost no earlier studies have tackled the problem of identifying an optimal preprocessing filter that yields effective features for input images. This paper proposes a novel design method for the optimal preprocessing filter corresponding to a given task. Our method calculates local image bases of the training dataset and represents the optimal filter as a linear combination of these local image bases with the optimized coefficients to maximize the expected generalization performance. Thereby, the optimization problem of the preprocessing filter is converted to a lower-dimensional optimization problem. Our proposed method combined with a higher-order local auto-correlation (HLAC) feature extraction exhibited the best performance both in the anomaly detection task with the conventional pattern recognition algorithm and in the classification task using the deep convolutional neural network compared with typical preprocessing filters.

BiLuNet: A Multi-Path Network for Semantic Segmentation on X-Ray Images

Van Luan Tran, Huei-Yung Lin, Rachel Liu, Chun-Han Tseng, Chun-Han Tseng

Auto-TLDR; BiLuNet: Multi-path Convolutional Neural Network for Semantic Segmentation of Lumbar vertebrae, sacrum,

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Semantic segmentation and shape detection of lumbar vertebrae, sacrum, and femoral heads from clinical X-ray images are important and challenging tasks. In this paper, we propose a new multi-path convolutional neural network, BiLuNet, for semantic segmentation on X-ray images. The network is capable of medical image segmentation with very limited training data. With the shape fitting of the bones, we can identify the location of the target regions very accurately for lumbar vertebra inspection. We collected our dataset and annotated by doctors for model training and performance evaluation. Compared to the state-of-the-art methods, the proposed technique provides better mIoUs and higher success rates with the same training data. The experimental results have demonstrated the feasibility of our network to perform semantic segmentation for lumbar vertebrae, sacrum, and femoral heads.

Merged 1D-2D Deep Convolutional Neural Networks for Nerve Detection in Ultrasound Images

Mohammad Alkhatib, Adel Hafiane, Pierre Vieyres

Auto-TLDR; A Deep Neural Network for Deep Neural Networks to Detect Median Nerve in Ultrasound-Guided Regional Anesthesia

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Ultrasound-Guided Regional Anesthesia (UGRA) becomes a standard procedure in surgical operations and contributes to pain management. It offers the advantages of the targeted nerve detection and provides the visualization of regions of interest such as anatomical structures. However, nerve detection is one of the most challenging tasks that anesthetists can encounter in the UGRA procedure. A computer-aided system that can detect automatically the nerve region would facilitate the anesthetist's daily routine and allow them to concentrate more on the anesthetic delivery. In this paper, we propose a new method based on merging deep learning models from different data to detect the median nerve. The merged architecture consists of two branches, one being one dimensional (1D) convolutional neural networks (CNN) branch and another 2D CNN branch. The merged architecture aims to learn the high-level features from 1D handcrafted noise-robust features and 2D ultrasound images. The obtained results show the validity and high accuracy of the proposed approach and its robustness.

On Identification and Retrieval of Near-Duplicate Biological Images: A New Dataset and Protocol

Thomas E. Koker, Sai Spandana Chintapalli, San Wang, Blake A. Talbot, Daniel Wainstock, Marcelo Cicconet, Mary C. Walsh

Auto-TLDR; BINDER: Bio-Image Near-Duplicate Examples Repository for Image Identification and Retrieval

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Manipulation and re-use of images in scientific publications is a growing issue, not only for biomedical publishers, but also for the research community in general. In this work we introduce BINDER -- Bio-Image Near-Duplicate Examples Repository, a novel dataset to help researchers develop, train, and test models to detect same-source biomedical images. BINDER contains 7,490 unique image patches for model training, 1,821 same-size patch duplicates for validation and testing, and 868 different-size image/patch pairs for image retrieval validation and testing. Except for the training set, patches already contain manipulations including rotation, translation, scale, perspective transform, contrast adjustment and/or compression artifacts. We further use the dataset to demonstrate how novel adaptations of existing image retrieval and metric learning models can be applied to achieve high-accuracy inference results, creating a baseline for future work. In aggregate, we thus present a supervised protocol for near-duplicate image identification and retrieval without any "real-world" training example. Our dataset and source code are available at hms-idac.github.io/BINDER.

Segmentation of Intracranial Aneurysm Remnant in MRA Using Dual-Attention Atrous Net

Subhashis Banerjee, Ashis Kumar Dhara, Johan Wikström, Robin Strand

Auto-TLDR; Dual-Attention Atrous Net for Segmentation of Intracranial Aneurysm Remnant from MRA Images

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Due to the advancement of non-invasive medical imaging modalities like Magnetic Resonance Angiography (MRA), an increasing number of Intracranial Aneurysm (IA) cases are being reported in recent years. The IAs are typically treated by so-called endovascular coiling, where blood flow in the IA is prevented by embolization with a platinum coil. Accurate quantification of the IA Remnant (IAR), i.e. the volume with blood flow present post treatment is the utmost important factor in choosing the right treatment planning. This is typically done by manually segmenting the aneurysm remnant from the MRA volume. Since manual segmentation of volumetric images is a labour-intensive and error-prone process, development of an automatic volumetric segmentation method is required. Segmentation of small structures such as IA, that may largely vary in size, shape, and location is considered extremely difficult. Similar intensity distribution of IAs and surrounding blood vessels makes it more challenging and susceptible to false positive. In this paper we propose a novel 3D CNN architecture called Dual-Attention Atrous Net (DAtt-ANet), which can efficiently segment IAR volumes from MRA images by reconciling features at different scales using the proposed Parallel Atrous Unit (PAU) along with the use of self-attention mechanism for extracting fine-grained features and intra-class correlation. The proposed DAtt-ANet model is trained and evaluated on a clinical MRA image dataset (prospective research project, approved by the local ethical committee) of IAR consisting of 46 subjects, annotated by an expert radiologist from our group. We compared the proposed DAtt-ANet with five state-of-the-art CNN models based on their segmentation performance. The proposed DAtt-ANet outperformed all other methods and was able to achieve a five-fold cross-validation DICE score of $0.73\pm0.06$.

Supporting Skin Lesion Diagnosis with Content-Based Image Retrieval

Stefano Allegretti, Federico Bolelli, Federico Pollastri, Sabrina Longhitano, Giovanni Pellacani, Costantino Grana

Auto-TLDR; Skin Images Retrieval Using Convolutional Neural Networks for Skin Lesion Classification and Segmentation

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Given the relevance of skin cancer, many attempts have been dedicated to the creation of automated devices that could assist both expert and beginner dermatologists towards fast and early diagnosis of skin lesions. In recent years, tasks such as skin lesion classification and segmentation have been extensively addressed with deep learning algorithms, which in some cases reach a diagnostic accuracy comparable to that of expert physicians. However, the general lack of interpretability and reliability severely hinders the ability of those approaches to actually support dermatologists in the diagnosis process. In this paper a novel skin images retrieval system is presented, which exploits features extracted by Convolutional Neural Networks to gather similar images from a publicly available dataset, in order to assist the diagnosis process of both expert and novice practitioners. In the proposed framework, Resnet-50 is initially trained for the classification of dermoscopic images; then, the feature extraction part is isolated, and an embedding network is build on top of it. The embedding learns an alternative representation, which allows to check image similarity by means of a distance measure. Experimental results reveal that the proposed method is able to select meaningful images, which can effectively boost the classification accuracy of human dermatologists.

Automatic Classification of Human Granulosa Cells in Assisted Reproductive Technology Using Vibrational Spectroscopy Imaging

Marina Paolanti, Emanuele Frontoni, Giorgia Gioacchini, Giorgini Elisabetta, Notarstefano Valentina, Zacà Carlotta, Carnevali Oliana, Andrea Borini, Marco Mameli

Auto-TLDR; Predicting Oocyte Quality in Assisted Reproductive Technology Using Machine Learning Techniques

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In the field of reproductive technology, the biochemical composition of female gametes has been successfully investigated with the use of vibrational spectroscopy. Currently, in assistive reproductive technology (ART), there are no shared criteria for the choice of oocyte, and automatic classification methods for the best quality oocytes have not yet been applied. In this paper, considering the lack of criteria in Assisted Reproductive Technology (ART), we use Machine Learning (ML) techniques to predict oocyte quality for a successful pregnancy. To improve the chances of successful implantation and minimize any complications during the pregnancy, Fourier transform infrared microspectroscopy (FTIRM) analysis has been applied on granulosa cells (GCs) collected along with the oocytes during oocyte aspiration, as it is routinely done in ART, and specific spectral biomarkers were selected by multivariate statistical analysis. A proprietary biological reference dataset (BRD) was successfully collected to predict the best oocyte for a successful pregnancy. Personal health information are stored, maintained and backed up using a cloud computing service. Using a user-friendly interface, the user will evaluate whether or not the selected oocyte will have a positive result. This interface includes a dashboard for retrospective analysis, reporting, real-time processing, and statistical analysis. The experimental results are promising and confirm the efficiency of the method in terms of classification metrics: precision, recall, and F1-score (F1) measures.

PCANet: Pyramid Context-Aware Network for Retinal Vessel Segmentation

Yi Zhang, Yixuan Chen, Kai Zhang

Auto-TLDR; PCANet: Adaptive Context-Aware Network for Automated Retinal Vessel Segmentation

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Automated retinal vessel segmentation plays an important role in the diagnosis of some diseases such as diabetes, arteriosclerosis and hypertension. Recent works attempt to improve segmentation performance by exploring either global or local contexts. However, the context demands are varying from regions in each image and different levels of network. To address these problems, we propose Pyramid Context-aware Network (PCANet), which can adaptively capture multi-scale context representations. Specifically, PCANet is composed of multiple Adaptive Context-aware (ACA) blocks arranged in parallel, each of which can adaptively obtain the context-aware features by estimating affinity coefficients at a specific scale under the guidance of global contextual dependencies. Meanwhile, we import ACA blocks with specific scales in different levels of the network to obtain a coarse-to-fine result. Furthermore, an integrated test-time augmentation method is developed to further boost the performance of PCANet. Finally, extensive experiments demonstrate the effectiveness of the proposed PCANet, and state-of-the-art performances are achieved with AUCs of 0.9866, 0.9886 and F1 Scores of 0.8274, 0.8371 on two public datasets, DRIVE and STARE, respectively.

A Novel Computer-Aided Diagnostic System for Early Assessment of Hepatocellular Carcinoma

Ahmed Alksas, Mohamed Shehata, Gehad Saleh, Ahmed Shaffie, Ahmed Soliman, Mohammed Ghazal, Hadil Abukhalifeh, Abdel Razek Ahmed, Ayman El-Baz

Auto-TLDR; Classification of Liver Tumor Lesions from CE-MRI Using Structured Structural Features and Functional Features

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Early assessment of liver cancer patients with hepatocellular carcinoma (HCC) is of immense importance to provide the proper treatment plan. In this paper, we have developed a two-stage classification computer-aided diagnostic (CAD) system that has the ability to detect and grade the liver observations from multiphase contrast enhanced magnetic resonance imaging (CE-MRI). The proposed approach consists of three main steps. First, a pre-processing is applied to the CE-MRI scans to delineate the tumor lesions that will be used as an ROI across the four different phases of the CE-MRI, (namely, the pre-contrast, late-arterial, portal-venous, and delayed-contrast). Second, a group of three features are modeled to provide a quantitative discrimination between the tumor lesions; namely: i) the tumor appearance that is modeled using a set of texture features, (namely; the first-order histogram, second-order gray-level co-occurrence matrix, and second-order gray-level run-length matrix), to capture any discrimination that may appear in the lesion texture, ii) the spherical harmonics (SH) based shape features that have the ability to describe the shape complexity of the liver tumors, and iii) the functional features that are based on the calculation of the wash-in/wash-out through that evaluate the intensity changes across the post-contrast phases. Finally, the aforementioned individual features were then integrated together to obtain the combined features to be fed to a machine learning classifier towards getting the final diagnostic decision. The proposed CAD system has been tested using hepatic observations that was obtained from 85 participating patients, 34 patients with benign tumors, 34 patients with intermediate tumors and 34 with malignant tumors. Using a random forests based classifier with a leave-one-subject-out (LOSO) cross-validation, the developed CAD system achieved an 87.1% accuracy in distinguishing the malignant, intermediate and benign tumors. The classification performance is then evaluated using k-fold (5/10-fold) cross-validation approach to examine the robustness of the system. The LR-1 lesions were classified from LR-2 benign lesions with 91.2% accuracy, while 85.3% accuracy was achieved differentiating between LR-4 and LR-5 malignant tumors. The obtained results hold a promise of the proposed framework to be reliably used as a noninvasive diagnostic tool for the early detection and grading of liver cancer tumors.

Deep Multiple Instance Learning with Spatial Attention for ROP Case Classification, Instance Selection and Abnormality Localization

Xirong Li, Wencui Wan, Yang Zhou, Jianchun Zhao, Qijie Wei, Junbo Rong, Pengyi Zhou, Limin Xu, Lijuan Lang, Yuying Liu, Chengzhi Niu, Dayong Ding, Xuemin Jin

Auto-TLDR; MIL-SA: Deep Multiple Instance Learning for Automated Screening of Retinopathy of Prematurity

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This paper tackles automated screening of Retinopathy of Prematurity (ROP), one of the most common causes of visual loss in childhood. Clinically, ROP screening per case requires multiple color fundus images capturing different zones of the premature retina. A desirable model shall not only make a decision at the case level, but also pinpoint which instances and what part of the instances are responsible for the decision. This paper makes the first attempt to accomplish three tasks, i.e, ROP case classification, instance selection and abnormality localization in a unified framework. To that end, we propose a new model that effectively combines instance-attention based deep multiple instance learning (MIL) and spatial attention (SA). The propose model, which we term MIL-SA, identifies positive instances in light of their contributions to case-level decision. Meanwhile, abnormal regions in the identified instances are automatically localized by the SA mechanism. Moreover, MIL-SA is learned from case-level binary labels exclusively, and in an end-to-end manner. Experiments on a large clinical dataset of 2,186 cases with 11,053 fundus images show the viability of the proposed model for all the three tasks.

EM-Net: Deep Learning for Electron Microscopy Image Segmentation

Afshin Khadangi, Thomas Boudier, Vijay Rajagopal

Auto-TLDR; EM-net: Deep Convolutional Neural Network for Electron Microscopy Image Segmentation

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Recent high-throughput electron microscopy techniques such as focused ion-beam scanning electron microscopy (FIB-SEM) provide thousands of serial sections which assist the biologists in studying sub-cellular structures at high resolution and large volume. Low contrast of such images hinder image segmentation and 3D visualisation of these datasets. With recent advances in computer vision and deep learning, such datasets can be segmented and reconstructed in 3D with greater ease and speed than with previous approaches. However, these methods still rely on thousands of ground-truth samples for training and electron microscopy datasets require significant amounts of time for carefully curated manual annotations. We address these bottlenecks with EM-net, a scalable deep convolutional neural network for EM image segmentation. We have evaluated EM-net using two datasets, one of which belongs to an ongoing competition on EM stack segmentation since 2012. We show that EM-net variants achieve better performances than current deep learning methods using small- and medium-sized ground-truth datasets. We also show that the ensemble of top EM-net base classifiers outperforms other methods across a wide variety of evaluation metrics.

Skin Lesion Classification Using Weakly-Supervised Fine-Grained Method

Xi Xue, Sei-Ichiro Kamata, Daming Luo

Auto-TLDR; Different Region proposal module for skin lesion classification

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In recent years, skin cancer has become one of the most common cancers. Among all types of skin cancers, melanoma is the most fatal one and many people die of this disease every year. Early detection can greatly reduce the death rate and save more lives. Skin lesions are one of the early symptoms of melanoma and other types of skin cancer. So accurately recognizing various skin lesions in early stage are of great significance. There have been lots of existing works based on convolutional neural networks (CNN) to solve skin lesion classification but seldom do them involve the similarity among different lesions. For example, we find that some lesions of melanoma and nevi look similar in appearance which is hard for neural network to distinguish categories of skin lesions. Inspired by fine-grained image classification, we propose a novel network to distinguish each category accurately. In our paper, we design an effective module, distinct region proposal module (DRPM), to extract the distinct regions from each image. Spatial attention and channel-wise attention are both utilized to enrich feature maps and guide the network to focus on the highlighted areas in a weakly-supervised way. In addition, two preprocessing steps are added to ensure the network to get better results. We demonstrate the potential of the proposed method on ISIC 2017 dataset. Experiments show that our approach is effective and efficient.

Epileptic Seizure Prediction: A Semi-Dilated Convolutional Neural Network Architecture

Ramy Hussein, Rabab K. Ward, Soojin Lee, Martin Mckeown

Auto-TLDR; Semi-Dilated Convolutional Network for Seizure Prediction using EEG Scalograms

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Despite many recent advances in machine learning and time-series classification, accurate prediction of seizures remains elusive. In this work, we develop a convolutional network module that uses Electroencephalogram (EEG) scalograms to distinguish between the pre-seizure and normal brain activities. Since the EEG scalogram takes rectangular image format with many more temporal bins than spectral bins, the presented module uses "semi-dilated convolutions" to also create a proportional non-square receptive field. The proposed semi-dilated convolutions support exponential expansion of the receptive field over the long dimension (image width, i.e. time) while maintaining high resolution over the short dimension (image height, i.e., frequency). The proposed architecture comprises a set of co-operative semi-dilated convolutional blocks, each block has a stack of parallel semi-dilated convolutional modules with different dilation rates. Results show that our proposed seizure prediction solution outperforms the state-of-the-art methods, achieving a seizure prediction sensitivity of 88.45% and 89.52% for the American Epilepsy Society and Melbourne University EEG datasets, respectively.

Evaluation of Anomaly Detection Algorithms for the Real-World Applications

Marija Ivanovska, Domen Tabernik, Danijel Skocaj, Janez Pers

Auto-TLDR; Evaluating Anomaly Detection Algorithms for Practical Applications

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Anomaly detection in complex data structures is oneof the most challenging problems in computer vision. In manyreal-world problems, for example in the quality control in modernmanufacturing, the anomalous samples are usually rare, resultingin (highly) imbalanced datasets. However, in current researchpractice, these scenarios are rarely modeled, and as a conse-quence, evaluation of anomaly detection algorithms often do notreproduce results that are useful for practical applications. First,even in case of highly unbalanced input data, anomaly detectionalgorithms are expected to significantly reduce the proportionof anomalous samples, detecting ”almost all” anomalous samples(with exact specifications depending on the target customer). Thisplaces high importance on only the small part of the ROC curve,possibly rendering the standard metrics such as AUC (AreaUnder Curve) and AP (Average Precision) useless. Second, thetarget of automatic anomaly detection in practical applicationsis significant reduction in manual work required, and standardmetrics are poor predictor of this feature. Finally, the evaluationmay produce erratic results for different randomly initializedtraining runs of the neural network, producing evaluation resultsthat may not reproduce well in practice. In this paper, we presentan evaluation methodology that avoids these pitfalls.

DE-Net: Dilated Encoder Network for Automated Tongue Segmentation

Hui Tang, Bin Wang, Jun Zhou, Yongsheng Gao

Auto-TLDR; Automated Tongue Image Segmentation using De-Net

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Automated tongue recognition is a growing research field due to global demand for personal health care. Using mobile devices to take tongue pictures is convenient and of low cost for tongue recognition. It is particularly suitable for self-health evaluation of the public. However, images taken by mobile devices are easily affected by various imaging environment, which makes fine segmentation a more challenging task compared with those taken by specialized acquisition devices. Deep learning approaches are promising for tongue image segmentation because they have powerful feature learning and representation capability. However, the successive pooling operations in these methods lead to loss of information on image details, making them fail when segmenting low-quality images captured by mobile devices. To address this issue, we propose a dilated encoder network (DE-Net) to capture more high-level features and get high-resolution output for automated tongue image segmentation. In addition, we construct two tongue image datasets which contain images taken by specialized devices and mobile devices, respectively, to verify the effectiveness of the proposed method. Experimental results on both datasets demonstrate that the proposed method outperforms the state-of-the-art methods in tongue image segmentation.

Fusion of Global-Local Features for Image Quality Inspection of Shipping Label

Sungho Suh, Paul Lukowicz, Yong Oh Lee

Auto-TLDR; Input Image Quality Verification for Automated Shipping Address Recognition and Verification

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The demands of automated shipping address recognition and verification have increased to handle a large number of packages and to save costs associated with misdelivery. A previous study proposed a deep learning system where the shipping address is recognized and verified based on a camera image capturing the shipping address and barcode area. Because the system performance depends on the input image quality, inspection of input image quality is necessary for image preprocessing. In this paper, we propose an input image quality verification method combining global and local features. Object detection and scale-invariant feature transform in different feature spaces are developed to extract global and local features from several independent convolutional neural networks. The conditions of shipping label images are classified by fully connected fusion layers with concatenated global and local features. The experimental results regarding real captured and generated images show that the proposed method achieves better performance than other methods. These results are expected to improve the shipping address recognition and verification system by applying different image preprocessing steps based on the classified conditions.

Generalized Iris Presentation Attack Detection Algorithm under Cross-Database Settings

Mehak Gupta, Vishal Singh, Akshay Agarwal, Mayank Vatsa, Richa Singh

Auto-TLDR; MVNet: A Deep Learning-based PAD Network for Iris Recognition against Presentation Attacks

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The deployment of biometrics features based person identification has increased significantly from border access to mobile unlock to electronic transactions. Iris recognition is considered as one of the most accurate biometric modality for person identification. However, the vulnerability of this recognition towards presentation attacks, especially towards the 3D contact lenses, can limit its potential deployments. The textured lenses are so effective in hiding the real texture of iris that it can fool not only the automatic recognition algorithms but also the human examiners. While in literature, several presentation attack detection (PAD) algorithms are presented; however, the significant limitation is the generalizability against an unseen database, unseen sensor, and different imaging environment. Inspired by the success of the hybrid algorithm or fusion of multiple detection networks, we have proposed a deep learning-based PAD network that utilizes multiple feature representation layers. The computational complexity is an essential factor in training the deep neural networks; therefore, to limit the computational complexity while learning multiple feature representation layers, a base model is kept the same. The network is trained end-to-end using a softmax classifier. We have evaluated the performance of the proposed network termed as MVNet using multiple databases such as IIITD-WVU MUIPA, IIITD-WVU UnMIPA database under cross-database training-testing settings. The experiments are performed extensively to assess the generalizability of the proposed algorithm.