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Progressive Adversarial Semantic Segmentation

Abdullah-Al-Zubaer Imran, Demetri Terzopoulos

Auto-TLDR; Progressive Adversarial Semantic Segmentation for End-to-End Medical Image Segmenting

Abstract Slides Poster

Medical image computing has advanced rapidly with the advent of deep learning techniques such as convolutional neural networks. Deep convolutional neural networks can perform exceedingly well given full supervision. However, the success of such fully-supervised models for various image analysis tasks (e.g., anatomy or lesion segmentation from medical images) is limited to the availability of massive amounts of labeled data. Given small sample sizes, such models are prohibitively data biased with large domain shift. To tackle this problem, we propose a novel end-to-end medical image segmentation model, namely Progressive Adversarial Semantic Segmentation (PASS), which can make improved segmentation predictions without requiring any domain-specific data during training time. Our extensive experimentation with 8 public diabetic retinopathy and chest X-ray datasets, confirms the effectiveness of PASS for accurate vascular and pulmonary segmentation, both for in-domain and cross-domain evaluations.

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MTGAN: Mask and Texture-Driven Generative Adversarial Network for Lung Nodule Segmentation

Wei Chen, Qiuli Wang, Kun Wang, Dan Yang, Xiaohong Zhang, Chen Liu, Yucong Li

Auto-TLDR; Mask and Texture-driven Generative Adversarial Network for Lung Nodule Segmentation

Abstract Slides Poster Similar

Accurate segmentation for lung nodules in lung computed tomography (CT) scans plays a key role in the early diagnosis of lung cancer. Many existing methods, especially UNet, have made significant progress in lung nodule segmentation. However, due to the complex shapes of lung nodules and the similarity of visual characteristics between nodules and lung tissues, an accurate segmentation with few false positives of lung nodules is still a challenging problem. Considering the fact that both boundary and texture information of lung nodules are important for obtaining an accurate segmentation result, we propose a novel Mask and Texture-driven Generative Adversarial Network (MTGAN) with a joint multi-scale L1 loss for lung nodule segmentation, which takes full advantages of U-Net and adversarial training. The proposed MTGAN leverages adversarial learning strategy guided by the boundary and texture information of lung nodules to generate more accurate segmentation results with lesser false positives. We validate our model with the LIDC–IDRI dataset, and experimental results show that our method achieves excellent segmentation results for a variety of lung nodules, especially for juxtapleural nodules and low-dense nodules. Without any bells and whistles, the proposed MTGAN achieves significant segmentation performance with the Dice similarity coefficient (DSC) of 85.24% on the LIDC–IDRI dataset.

Transfer Learning through Weighted Loss Function and Group Normalization for Vessel Segmentation from Retinal Images

Abdullah Sarhan, Jon Rokne, Reda Alhajj, Andrew Crichton

Auto-TLDR; Deep Learning for Segmentation of Blood Vessels in Retinal Images

Abstract Slides Poster Similar

The vascular structure of blood vessels is important in diagnosing retinal conditions such as glaucoma and diabetic retinopathy. Accurate segmentation of these vessels can help in detecting retinal objects such as the optic disc and optic cup and hence determine if there are damages to these areas. Moreover, the structure of the vessels can help in diagnosing glaucoma. The rapid development of digital imaging and computer-vision techniques has increased the potential for developing approaches for segmenting retinal vessels. In this paper, we propose an approach for segmenting retinal vessels that uses deep learning along with transfer learning. We adapted the U-Net structure to use a customized InceptionV3 as the encoder and used multiple skip connections to form the decoder. Moreover, we used a weighted loss function to handle the issue of class imbalance in retinal images. Furthermore, we contributed a new dataset to this field. We tested our approach on six publicly available datasets and a newly created dataset. We achieved an average accuracy of 95.60\% and a Dice coefficient of 80.98\%. The results obtained from comprehensive experiments demonstrate the robustness of our approach to the segmentation of blood vessels in retinal images obtained from different sources. Our approach results in greater segmentation accuracy than other approaches.

Semi-Supervised Generative Adversarial Networks with a Pair of Complementary Generators for Retinopathy Screening

Yingpeng Xie, Qiwei Wan, Hai Xie, En-Leng Tan, Yanwu Xu, Baiying Lei

Auto-TLDR; Generative Adversarial Networks for Retinopathy Diagnosis via Fundus Images

Abstract Slides Poster Similar

Several typical types of retinopathy are major causes of blindness. However, early detection of retinopathy is quite not easy since few symptoms are observable in the early stage, attributing to the development of non-mydriatic retinal camera. These camera produces high-resolution retinal fundus images provide the possibility of Computer-Aided-Diagnosis (CAD) via deep learning to assist diagnosing retinopathy. Deep learning algorithms usually rely on a great number of labelled images which are expensive and time-consuming to obtain in the medical imaging area. Moreover, the random distribution of various lesions which often vary greatly in size also brings significant challenges to learn discriminative information from high-resolution fundus image. In this paper, we present generative adversarial networks simultaneously equipped with "good" generator and "bad" generator (GBGANs) to make up for the incomplete data distribution provided by limited fundus images. To improve the generative feasibility of generator, we introduce into pre-trained feature extractor to acquire condensed feature for each fundus image in advance. Experimental results on integrated three public iChallenge datasets show that the proposed GBGANs could fully utilize the available fundus images to identify retinopathy with little label cost.

Unsupervised Domain Adaptation with Multiple Domain Discriminators and Adaptive Self-Training

Teo Spadotto, Marco Toldo, Umberto Michieli, Pietro Zanuttigh

Auto-TLDR; Unsupervised Domain Adaptation for Semantic Segmentation of Urban Scenes

Abstract Slides Poster Similar

Unsupervised Domain Adaptation (UDA) aims at improving the generalization capability of a model trained on a source domain to perform well on a target domain for which no labeled data is available. In this paper, we consider the semantic segmentation of urban scenes and we propose an approach to adapt a deep neural network trained on synthetic data to real scenes addressing the domain shift between the two different data distributions. We introduce a novel UDA framework where a standard supervised loss on labeled synthetic data is supported by an adversarial module and a self-training strategy aiming at aligning the two domain distributions. The adversarial module is driven by a couple of fully convolutional discriminators dealing with different domains: the first discriminates between ground truth and generated maps, while the second between segmentation maps coming from synthetic or real world data. The self-training module exploits the confidence estimated by the discriminators on unlabeled data to select the regions used to reinforce the learning process. Furthermore, the confidence is thresholded with an adaptive mechanism based on the per-class overall confidence. Experimental results prove the effectiveness of the proposed strategy in adapting a segmentation network trained on synthetic datasets like GTA5 and SYNTHIA, to real world datasets like Cityscapes and Mapillary.

Learn to Segment Retinal Lesions and Beyond

Qijie Wei, Xirong Li, Weihong Yu, Xiao Zhang, Yongpeng Zhang, Bojie Hu, Bin Mo, Di Gong, Ning Chen, Dayong Ding, Youxin Chen

Auto-TLDR; Multi-task Lesion Segmentation and Disease Classification for Diabetic Retinopathy Grading

Abstract Poster Similar

Towards automated retinal screening, this paper makes an endeavor to simultaneously achieve pixel-level retinal lesion segmentation and image-level disease classification. Such a multi-task approach is crucial for accurate and clinically interpretable disease diagnosis. Prior art is insufficient due to three challenges, i.e., lesions lacking objective boundaries, clinical importance of lesions irrelevant to their size, and the lack of one-to-one correspondence between lesion and disease classes. This paper attacks the three challenges in the context of diabetic retinopathy (DR) grading. We propose Lesion-Net, a new variant of fully convolutional networks, with its expansive path re- designed to tackle the first challenge. A dual Dice loss that leverages both semantic segmentation and image classification losses is introduced to resolve the second challenge. Lastly, we build a multi-task network that employs Lesion-Net as a side- attention branch for both DR grading and result interpretation. A set of 12K fundus images is manually segmented by 45 ophthalmologists for 8 DR-related lesions, resulting in 290K manual segments in total. Extensive experiments on this large- scale dataset show that our proposed approach surpasses the prior art for multiple tasks including lesion segmentation, lesion classification and DR grading.

PCANet: Pyramid Context-Aware Network for Retinal Vessel Segmentation

Yi Zhang, Yixuan Chen, Kai Zhang

Auto-TLDR; PCANet: Adaptive Context-Aware Network for Automated Retinal Vessel Segmentation

Abstract Slides Poster Similar

Automated retinal vessel segmentation plays an important role in the diagnosis of some diseases such as diabetes, arteriosclerosis and hypertension. Recent works attempt to improve segmentation performance by exploring either global or local contexts. However, the context demands are varying from regions in each image and different levels of network. To address these problems, we propose Pyramid Context-aware Network (PCANet), which can adaptively capture multi-scale context representations. Specifically, PCANet is composed of multiple Adaptive Context-aware (ACA) blocks arranged in parallel, each of which can adaptively obtain the context-aware features by estimating affinity coefficients at a specific scale under the guidance of global contextual dependencies. Meanwhile, we import ACA blocks with specific scales in different levels of the network to obtain a coarse-to-fine result. Furthermore, an integrated test-time augmentation method is developed to further boost the performance of PCANet. Finally, extensive experiments demonstrate the effectiveness of the proposed PCANet, and state-of-the-art performances are achieved with AUCs of 0.9866, 0.9886 and F1 Scores of 0.8274, 0.8371 on two public datasets, DRIVE and STARE, respectively.

Automatic Semantic Segmentation of Structural Elements related to the Spinal Cord in the Lumbar Region by Using Convolutional Neural Networks

Jhon Jairo Sáenz Gamboa, Maria De La Iglesia-Vaya, Jon Ander Gómez

Auto-TLDR; Semantic Segmentation of Lumbar Spine Using Convolutional Neural Networks

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This work addresses the problem of automatically segmenting the MR images corresponding to the lumbar spine. The purpose is to detect and delimit the different structural elements like vertebrae, intervertebral discs, nerves, blood vessels, etc. This task is known as semantic segmentation. The approach proposed in this work is based on convolutional neural networks whose output is a mask where each pixel from the input image is classified into one of the possible classes. Classes were defined by radiologists and correspond to structural elements and tissues. The proposed network architectures are variants of the U-Net. Several complementary blocks were used to define the variants: spatial attention models, deep supervision and multi-kernels at input, this last block type is based on the idea of inception. Those architectures which got the best results are described in this paper, and their results are discussed. Two of the proposed architectures outperform the standard U-Net used as baseline.

A Benchmark Dataset for Segmenting Liver, Vasculature and Lesions from Large-Scale Computed Tomography Data

Bo Wang, Zhengqing Xu, Wei Xu, Qingsen Yan, Liang Zhang, Zheng You

Auto-TLDR; The Biggest Treatment-Oriented Liver Cancer Dataset for Segmentation

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How to build a high-performance liver-related computer assisted diagnosis system is an open question of great interest. However, the performance of the state-of-art algorithm is always limited by the amount of data and quality of the label. To address this problem, we propose the biggest treatment-oriented liver cancer dataset for liver surgery and treatment planning. This dataset provides 216 cases (totally about 268K frames) scanned images in contrast-enhanced computed tomography (CT). We labeled all the CT images with the liver, liver vasculature and liver tumor segmentation ground truth for train and tune segmentation algorithms in advance. Based on that, we evaluate several recent and state-of-the-art segmentation algorithms, including 7 deep learning methods, on CT sequences. All results are compared to reference segmentations five error metrics that highlight different aspects of segmentation accuracy. In general, compared with previous datasets, our dataset is really a challenging dataset. To our knowledge, the proposed dataset and benchmark allow for the first time systematic exploration of such issues, and will be made available to allow for further research in this field.

SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentation

Changlu Guo, Marton Szemenyei, Yugen Yi, Wenle Wang, Buer Chen, Changqi Fan

Auto-TLDR; Spatial Attention U-Net for Segmentation of Retinal Blood Vessels

Abstract Slides Poster Similar

The precise segmentation of retinal blood vessels is of great significance for early diagnosis of eye-related diseases such as diabetes and hypertension. In this work, we propose a lightweight network named Spatial Attention U-Net (SA-UNet) that does not require thousands of annotated training samples and can be utilized in a data augmentation manner to use the available annotated samples more efficiently. SA-UNet introduces a spatial attention module which infers the attention map along the spatial dimension, and multiplies the attention map by the input feature map for adaptive feature refinement. In addition, the proposed network employs structured dropout convolutional blocks instead of the original convolutional blocks of U-Net to prevent the network from overfitting. We evaluate SA-UNet based on two benchmark retinal datasets: the Vascular Extraction (DRIVE) dataset and the Child Heart and Health Study (CHASE_DB1) dataset. The results show that the proposed SA-UNet achieves state-of-the-art performance on both datasets.The implementation and the trained networks are available on Github1.

BG-Net: Boundary-Guided Network for Lung Segmentation on Clinical CT Images

Rui Xu, Yi Wang, Tiantian Liu, Xinchen Ye, Lin Lin, Yen-Wei Chen, Shoji Kido, Noriyuki Tomiyama

Auto-TLDR; Boundary-Guided Network for Lung Segmentation on CT Images

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Lung segmentation on CT images is a crucial step for a computer-aided diagnosis system of lung diseases. The existing deep learning based lung segmentation methods are less efficient to segment lungs on clinical CT images, especially that the segmentation on lung boundaries is not accurate enough due to complex pulmonary opacities in practical clinics. In this paper, we propose a boundary-guided network (BG-Net) to address this problem. It contains two auxiliary branches that separately segment lungs and extract the lung boundaries, and an aggregation branch that efficiently exploits lung boundary cues to guide the network for more accurate lung segmentation on clinical CT images. We evaluate the proposed method on a private dataset collected from the Osaka university hospital and four public datasets including StructSeg, HUG, VESSEL12, and a Novel Coronavirus 2019 (COVID-19) dataset. Experimental results show that the proposed method can segment lungs more accurately and outperform several other deep learning based methods.

Segmentation of Intracranial Aneurysm Remnant in MRA Using Dual-Attention Atrous Net

Subhashis Banerjee, Ashis Kumar Dhara, Johan Wikström, Robin Strand

Auto-TLDR; Dual-Attention Atrous Net for Segmentation of Intracranial Aneurysm Remnant from MRA Images

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Due to the advancement of non-invasive medical imaging modalities like Magnetic Resonance Angiography (MRA), an increasing number of Intracranial Aneurysm (IA) cases are being reported in recent years. The IAs are typically treated by so-called endovascular coiling, where blood flow in the IA is prevented by embolization with a platinum coil. Accurate quantification of the IA Remnant (IAR), i.e. the volume with blood flow present post treatment is the utmost important factor in choosing the right treatment planning. This is typically done by manually segmenting the aneurysm remnant from the MRA volume. Since manual segmentation of volumetric images is a labour-intensive and error-prone process, development of an automatic volumetric segmentation method is required. Segmentation of small structures such as IA, that may largely vary in size, shape, and location is considered extremely difficult. Similar intensity distribution of IAs and surrounding blood vessels makes it more challenging and susceptible to false positive. In this paper we propose a novel 3D CNN architecture called Dual-Attention Atrous Net (DAtt-ANet), which can efficiently segment IAR volumes from MRA images by reconciling features at different scales using the proposed Parallel Atrous Unit (PAU) along with the use of self-attention mechanism for extracting fine-grained features and intra-class correlation. The proposed DAtt-ANet model is trained and evaluated on a clinical MRA image dataset (prospective research project, approved by the local ethical committee) of IAR consisting of 46 subjects, annotated by an expert radiologist from our group. We compared the proposed DAtt-ANet with five state-of-the-art CNN models based on their segmentation performance. The proposed DAtt-ANet outperformed all other methods and was able to achieve a five-fold cross-validation DICE score of $0.73\pm0.06$.

NephCNN: A Deep-Learning Framework for Vessel Segmentation in Nephrectomy Laparoscopic Videos

Alessandro Casella, Sara Moccia, Chiara Carlini, Emanuele Frontoni, Elena De Momi, Leonardo Mattos

Auto-TLDR; Adversarial Fully Convolutional Neural Networks for kidney vessel segmentation from nephrectomy laparoscopic videos

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Objective: In the last years, Robot-assisted partial nephrectomy (RAPN) is establishing as elected treatment for renal cell carcinoma (RCC). Reduced field of view, field occlusions by surgical tools, and reduced maneuverability may potentially cause accidents, such as unwanted vessel resection with consequent bleeding. Surgical Data Science (SDS) can provide effective context-aware tools for supporting surgeons. However, currently no tools have been exploited for automatic vessels segmentation from nephrectomy laparoscopic videos. Herein, we propose a new approach based on adversarial Fully Convolutional Neural Networks (FCNNs) to kidney vessel segmentation from nephrectomy laparoscopic vision. Methods: The proposed approach enhances existing segmentation framework by (i) encoding 3D kernels for spatio-temporal features extraction to enforce pixel connectivity in time, and (ii) perform training in adversarial fashion, which constrains vessels shape. Results: We performed a preliminary study using 8 different RAPN videos (1871 frames), the first in the field, achieving a median Dice Similarity Coefficient of 71.76%. Conclusions: Results showed that the proposed approach could be a valuable solution with a view to assist surgeon during RAPN.

BiLuNet: A Multi-Path Network for Semantic Segmentation on X-Ray Images

Van Luan Tran, Huei-Yung Lin, Rachel Liu, Chun-Han Tseng, Chun-Han Tseng

Auto-TLDR; BiLuNet: Multi-path Convolutional Neural Network for Semantic Segmentation of Lumbar vertebrae, sacrum,

Abstract Similar

Semantic segmentation and shape detection of lumbar vertebrae, sacrum, and femoral heads from clinical X-ray images are important and challenging tasks. In this paper, we propose a new multi-path convolutional neural network, BiLuNet, for semantic segmentation on X-ray images. The network is capable of medical image segmentation with very limited training data. With the shape fitting of the bones, we can identify the location of the target regions very accurately for lumbar vertebra inspection. We collected our dataset and annotated by doctors for model training and performance evaluation. Compared to the state-of-the-art methods, the proposed technique provides better mIoUs and higher success rates with the same training data. The experimental results have demonstrated the feasibility of our network to perform semantic segmentation for lumbar vertebrae, sacrum, and femoral heads.

End-To-End Multi-Task Learning for Lung Nodule Segmentation and Diagnosis

Wei Chen, Qiuli Wang, Dan Yang, Xiaohong Zhang, Chen Liu, Yucong Li

Auto-TLDR; A novel multi-task framework for lung nodule diagnosis based on deep learning and medical features

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Computer-Aided Diagnosis (CAD) systems for lung nodule diagnosis based on deep learning have attracted much attention in recent years. However, most existing methods ignore the relationships between the segmentation and classification tasks, which leads to unstable performances. To address this problem, we propose a novel multi-task framework, which can provide lung nodule segmentation mask, malignancy prediction, and medical features for interpretable diagnosis at the same time. Our framework mainly contains two sub-network: (1) Multi-Channel Segmentation Sub-network (MSN) for lung nodule segmentation, and (2) Joint Classification Sub-network (JCN) for interpretable lung nodule diagnosis. In the proposed framework, we use U-Net down-sampling processes for extracting low-level deep learning features, which are shared by two sub-networks. The JCN forces the down-sampling processes to learn better lowlevel deep features, which lead to a better construct of segmentation masks. Meanwhile, two additional channels constructed by OTSU and super-pixel (SLIC) methods, are utilized as the guideline of the feature extraction. The proposed framework takes advantages of deep learning methods and classical methods, which can significantly improve the performances of all tasks. We evaluate the proposed framework on public dataset LIDCIDRI. Our framework achieves a promising Dice score of 86.43% in segmentation, 87.07% in malignancy level prediction, and convincing results in interpretable medical feature predictions.

Bridging the Gap between Natural and Medical Images through Deep Colorization

Lia Morra, Luca Piano, Fabrizio Lamberti, Tatiana Tommasi

Auto-TLDR; Transfer Learning for Diagnosis on X-ray Images Using Color Adaptation

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Deep learning has thrived by training on large-scale datasets. However, in many applications, as for medical image diagnosis, getting massive amount of data is still prohibitive due to privacy, lack of acquisition homogeneity and annotation cost. In this scenario transfer learning from natural image collections is a standard practice that attempts to tackle shape, texture and color discrepancy all at once through pretrained model fine-tuning. In this work we propose to disentangle those challenges and design a dedicated network module that focuses on color adaptation. We combine learning from scratch of the color module with transfer learning of different classification backbones obtaining an end-to-end, easy-to-train architecture for diagnostic image recognition on X-ray images. Extensive experiments show how our approach is particularly efficient in case of data scarcity and provides a new path for further transferring the learned color information across multiple medical datasets.

Unsupervised Detection of Pulmonary Opacities for Computer-Aided Diagnosis of COVID-19 on CT Images

Rui Xu, Xiao Cao, Yufeng Wang, Yen-Wei Chen, Xinchen Ye, Lin Lin, Wenchao Zhu, Chao Chen, Fangyi Xu, Yong Zhou, Hongjie Hu, Shoji Kido, Noriyuki Tomiyama

Auto-TLDR; A computer-aided diagnosis of COVID-19 from CT images using unsupervised pulmonary opacity detection

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COVID-19 emerged towards the end of 2019 which was identified as a global pandemic by the world heath organization (WHO). With the rapid spread of COVID-19, the number of infected and suspected patients has increased dramatically. Chest computed tomography (CT) has been recognized as an efficient tool for the diagnosis of COVID-19. However, the huge CT data make it difficult for radiologist to fully exploit them on the diagnosis. In this paper, we propose a computer-aided diagnosis system that can automatically analyze CT images to distinguish the COVID-19 against to community-acquired pneumonia (CAP). The proposed system is based on an unsupervised pulmonary opacity detection method that locates opacity regions by a detector unsupervisedly trained from CT images with normal lung tissues. Radiomics based features are extracted insides the opacity regions, and fed into classifiers for classification. We evaluate the proposed CAD system by using 200 CT images collected from different patients in several hospitals. The accuracy, precision, recall, f1-score and AUC achieved are 95.5%, 100%, 91%, 95.1% and 95.9% respectively, exhibiting the promising capacity on the differential diagnosis of COVID-19 from CT images.

Unsupervised Multi-Task Domain Adaptation

Shih-Min Yang, Mei-Chen Yeh

Auto-TLDR; Unsupervised Domain Adaptation with Multi-task Learning for Image Recognition

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With abundant labeled data, deep convolutional neural networks have shown great success in various image recognition tasks. However, these models are often less powerful when applied to novel datasets due to a phenomenon known as domain shift. Unsupervised domain adaptation methods aim to address this problem, allowing deep models trained on the labeled source domain to be used on a different target domain (without labels). In this paper, we investigate whether the generalization ability of an unsupervised domain adaptation method can be improved through multi-task learning, with learned features required to be both domain invariant and discriminative for multiple different but relevant tasks. Experiments evaluating two fundamental recognition tasks---including image recognition and segmentation--- show that the generalization ability empowered by multi-task learning may not benefit recognition when the model is directly applied on the target domain, but the multi-task setting can boost the performance of state-of-the-art unsupervised domain adaptation methods by a non-negligible margin.

Planar 3D Transfer Learning for End to End Unimodal MRI Unbalanced Data Segmentation

Martin Kolarik, Radim Burget, Carlos M. Travieso-Gonzalez, Jan Kocica

Auto-TLDR; Planar 3D Res-U-Net Network for Unbalanced 3D Image Segmentation using Fluid Attenuation Inversion Recover

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We present a novel approach of 2D to 3D transfer learning based on mapping pre-trained 2D convolutional neural network weights into planar 3D kernels. The method is validated by proposed planar 3D res-u-net network with encoder transferred from the 2D VGG-16 which is applied for a single-stage unbalanced 3D image data segmentation. In particular, we evaluate the method on the MICCAI 2016 MS lesion segmentation challenge dataset utilizing solely Fluid Attenuation Inversion Recover (FLAIR) sequence without brain extraction for training and inference to simulate real medical praxis. The planar 3D res-u-net network performed the best both in sensitivity and Dice score amongst end to end methods processing raw MRI scans and achieved comparable Dice score to a state-of-the-art unimodal not end to end approach. Complete source code was released under the open-source license and this paper is in compliance with the Machine learning Reproducibility Checklist. By implementing practical transfer learning for 3D data representation we were able to successfully segment heavily unbalanced data without selective sampling and achieved more reliable results using less training data in single modality. From medical perspective, the unimodal approach gives an advantage in real praxis as it does not require co-registration nor additional scanning time during examination. Although modern medical imaging methods capture high resolution 3D anatomy scans suitable for computer aided detection system processing, deployment of automatic systems for interpretation of radiology imaging is still rather theoretical in many medical areas. Our work aims to bridge the gap offering solution for partial research questions.

CAggNet: Crossing Aggregation Network for Medical Image Segmentation

Xu Cao, Yanghao Lin

Auto-TLDR; Crossing Aggregation Network for Medical Image Segmentation

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In this paper, we present Crossing Aggregation Network (CAggNet), a novel densely connected semantic segmentation method for medical image analysis. The crossing aggregation network absorbs the idea of deep layer aggregation and makes significant innovations in layer connection and semantic information fusion. In this architecture, the traditional skip-connection structure of general U-Net is replaced by aggregations of multi-level down-sampling and up-sampling layers. This enables the network to fuse information interactively flows at different levels of layers in semantic segmentation. It also introduces weighted aggregation module to aggregate multi-scale output information. We have evaluated and compared our CAggNet with several advanced U-Net based methods in two public medical image datasets, including the 2018 Data Science Bowl nuclei detection dataset and the 2015 MICCAI gland segmentation competition dataset. Experimental results indicate that CAggNet improves medical object recognition and achieves a more accurate and efficient segmentation compared to existing improved U-Net and UNet++ structure.

Robust Localization of Retinal Lesions Via Weakly-Supervised Learning

Ruohan Zhao, Qin Li, Jane You

Auto-TLDR; Weakly Learning of Lesions in Fundus Images Using Multi-level Feature Maps and Classification Score

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Retinal fundus images reveal the condition of retina, blood vessels and optic nerve. Retinal imaging is becoming widely adopted in clinical work because any subtle changes to the structures at the back of the eyes can affect the eyes and indicate the overall health. Machine learning, in particular deep learning by convolutional neural network (CNN), has been increasingly adopted for computer-aided detection (CAD) of retinal lesions. However, a significant barrier to the high performance of CNN based CAD approach is caused by the lack of sufficient labeled ground-truth image samples for training. Unlike the fully-supervised learning which relies on pixel-level annotation of pathology in fundus images, this paper presents a new approach to discriminate the location of various lesions based on image-level labels via weakly learning. More specifically, our proposed method leverages multi-level feature maps and classification score to cope with both bright and red lesions in fundus images. To enhance capability of learning less discriminative parts of objects (e.g. small blobs of microaneurysms opposed to bulk of exudates), the classifier is regularized by refining images with corresponding labels. The experimental results of the performance evaluation and benchmarking at both image-level and pixel-level on the public DIARETDB1 dataset demonstrate the feasibility and excellent potentials of our method in practice.

Cross-Domain Semantic Segmentation of Urban Scenes Via Multi-Level Feature Alignment

Bin Zhang, Shengjie Zhao, Rongqing Zhang

Auto-TLDR; Cross-Domain Semantic Segmentation Using Generative Adversarial Networks

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Semantic segmentation is an essential task in plenty of real-life applications such as virtual reality, video analysis, autonomous driving, etc. Recent advancements in fundamental vision-based tasks ranging from image classification to semantic segmentation have demonstrated deep learning-based models' high capability in learning complicated representation on large datasets. Nevertheless, manually labeling semantic segmentation dataset with pixel-level annotation is extremely labor-intensive. To address this problem, we propose a novel multi-level feature alignment framework for cross-domain semantic segmentation of urban scenes by exploiting generative adversarial networks. In the proposed multi-level feature alignment method, we first translate images from one domain to another one. Then the discriminative feature representations extracted by the deep neural network are concatenated, followed by domain adversarial learning to make the intermediate feature distribution of the target domain images close to those in the source domain. With these domain adaptation techniques, models trained with images in the source domain where the labels are easy to acquire can be deployed to the target domain where the labels are scarce. Experimental evaluations on various mainstream benchmarks confirm the effectiveness as well as robustness of our approach.

Shape Consistent 2D Keypoint Estimation under Domain Shift

Levi Vasconcelos, Massimiliano Mancini, Davide Boscaini, Barbara Caputo, Elisa Ricci

Auto-TLDR; Deep Adaptation for Keypoint Prediction under Domain Shift

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Recent unsupervised domain adaptation methods based on deep architectures have shown remarkable performance not only in traditional classification tasks but also in more complex problems involving structured predictions (e.g. semantic segmentation, depth estimation). Following this trend, in this paper we present a novel deep adaptation framework for estimating keypoints under \textit{domain shift}, i.e. when the training (\textit{source}) and the test (\textit{target}) images significantly differ in terms of visual appearance. Our method seamlessly combines three different components: feature alignment, adversarial training and self-supervision. Specifically, our deep architecture leverages from domain-specific distribution alignment layers to perform target adaptation at the feature level. Furthermore, a novel loss is proposed which combines an adversarial term for ensuring aligned predictions in the output space and a geometric consistency term which guarantees coherent predictions between a target sample and its perturbed version. Our extensive experimental evaluation conducted on three publicly available benchmarks shows that our approach outperforms state-of-the-art domain adaptation methods in the 2D keypoint prediction task.

FOANet: A Focus of Attention Network with Application to Myocardium Segmentation

Zhou Zhao, Elodie Puybareau, Nicolas Boutry, Thierry Geraud

Auto-TLDR; FOANet: A Hybrid Loss Function for Myocardium Segmentation of Cardiac Magnetic Resonance Images

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In myocardium segmentation of cardiac magnetic resonance images, ambiguities often appear near the boundaries of the target domains due to tissue similarities. To address this issue, we propose a new architecture, called FOANet, which can be decomposed in three main steps: a localization step, a Gaussian-based contrast enhancement step, and a segmentation step. This architecture is supplied with a hybrid loss function that guides the FOANet to study the transformation relationship between the input image and the corresponding label in a threelevel hierarchy (pixel-, patch- and map-level), which is helpful to improve segmentation and recovery of the boundaries. We demonstrate the efﬁciency of our approach on two public datasets in terms of regional and boundary segmentations.

Foreground-Focused Domain Adaption for Object Detection

Yuchen Yang, Nilanjan Ray

Auto-TLDR; Unsupervised Domain Adaptation for Unsupervised Object Detection

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Object detectors suffer from accuracy loss caused by domain shift from a source to a target domain. Unsupervised domain adaptation (UDA) approaches mitigate this loss by training with unlabeled target domain images. A popular processing pipeline applies adversarial training that aligns the distributions of the features from the two domains. We advocate that aligning the full image level features is not ideal for UDA object detection due to the presence of varied background areas during inference. Thus, we propose a novel foreground-focused domain adaptation (FFDA) framework which mines the loss of the domain discriminators to concentrate on the backpropagation of foreground loss. We obtain mining masks by collecting target predictions and source labels to outline foreground regions, and apply the masks to image and instance level domain discriminators to allow backpropagation only on the mined regions. By reinforcing this foreground-focused adaptation throughout multiple layers in the detector model, we gain a significant accuracy boost on the target domain prediction. Compared to previous works, our method reaches the new state-of-the-art accuracy on adapting Cityscape to Foggy Cityscape dataset and demonstrates competitive accuracy on other datasets that include various scenarios for autonomous driving applications.

Learning to Segment Clustered Amoeboid Cells from Brightfield Microscopy Via Multi-Task Learning with Adaptive Weight Selection

Rituparna Sarkar, Suvadip Mukherjee, Elisabeth Labruyere, Jean-Christophe Olivo-Marin

Auto-TLDR; Supervised Cell Segmentation from Microscopy Images using Multi-task Learning in a Multi-Task Learning Paradigm

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Detecting and segmenting individual cells from microscopy images is critical to various life science applications. Traditional cell segmentation tools are often ill-suited for applications in brightfield microscopy due to poor contrast and intensity heterogeneity, and only a small subset are applicable to segment cells in a cluster. In this regard, we introduce a novel supervised technique for cell segmentation in a multi-task learning paradigm. A combination of a multi-task loss, based on the region and cell boundary detection, is employed for an improved prediction efficiency of the network. The learning problem is posed in a novel min-max framework which enables adaptive estimation of the hyper-parameters in an automatic fashion. The region and cell boundary predictions are combined via morphological operations and active contour model to segment individual cells. The proposed methodology is particularly suited to segment touching cells from brightfield microscopy images without manual interventions. Quantitatively, we observe an overall Dice score of 0.93 on the validation set, which is an improvement of over 15.9% on a recent unsupervised method, and outperforms the popular supervised U-net algorithm by at least 5.8% on average.

Deep Recurrent-Convolutional Model for AutomatedSegmentation of Craniomaxillofacial CT Scans

Francesca Murabito, Simone Palazzo, Federica Salanitri Proietto, Francesco Rundo, Ulas Bagci, Daniela Giordano, Rosalia Leonardi, Concetto Spampinato

Auto-TLDR; Automated Segmentation of Anatomical Structures in Craniomaxillofacial CT Scans using Fully Convolutional Deep Networks

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In this paper we define a deep learning architecture for automated segmentation of anatomical structures in Craniomaxillofacial (CMF) CT scans that leverages the recent success of encoder-decoder models for semantic segmentation of natural images. In particular, we propose a fully convolutional deep network that combines the advantages of recent fully convolutional models, such as Tiramisu, with squeeze-and-excitation blocks for feature recalibration, integrated with convolutional LSTMs to model spatio-temporal correlations between consecutive slices. The proposed segmentation network shows superior performance and generalization capabilities (to different structures and imaging modalities) than state of the art methods on automated segmentation of CMF structures (e.g., mandibles and airways) in several standard benchmarks (e.g., MICCAI datasets) and on new datasets proposed herein, effectively facing shape variability.

BCAU-Net: A Novel Architecture with Binary Channel Attention Module for MRI Brain Segmentation

Yongpei Zhu, Zicong Zhou, Guojun Liao, Kehong Yuan

Auto-TLDR; BCAU-Net: Binary Channel Attention U-Net for MRI brain segmentation

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Recently deep learning-based networks have achieved advanced performance in medical image segmentation. However, the development of deep learning is slow in magnetic resonance image (MRI) segmentation of normal brain tissues. In this paper, inspired by channel attention module, we propose a new architecture, Binary Channel Attention U-Net (BCAU-Net), by introducing a novel Binary Channel Attention Module (BCAM) into skip connection of U-Net, which can take full advantages of the channel information extracted from the encoding path and corresponding decoding path. To better aggregate multi-scale spatial information of the feature map, spatial pyramid pooling (SPP) modules with different pooling operations are used in BCAM instead of original average-pooling and max-pooling operations. We verify this model on two datasets including IBSR and MRBrainS18, and obtain better performance on MRI brain segmentation compared with other methods. We believe the proposed method can advance the performance in brain segmentation and clinical diagnosis.

Semi-Supervised Domain Adaptation Via Selective Pseudo Labeling and Progressive Self-Training

Yoonhyung Kim, Changick Kim

Auto-TLDR; Semi-supervised Domain Adaptation with Pseudo Labels

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Domain adaptation (DA) is a representation learning methodology that transfers knowledge from a label-sufficient source domain to a label-scarce target domain. While most of early methods are focused on unsupervised DA (UDA), several studies on semi-supervised DA (SSDA) are recently suggested. In SSDA, a small number of labeled target images are given for training, and the effectiveness of those data is demonstrated by the previous studies. However, the previous SSDA approaches solely adopt those data for embedding ordinary supervised losses, overlooking the potential usefulness of the few yet informative clues. Based on this observation, in this paper, we propose a novel method that further exploits the labeled target images for SSDA. Specifically, we utilize labeled target images to selectively generate pseudo labels for unlabeled target images. In addition, based on the observation that pseudo labels are inevitably noisy, we apply a label noise-robust learning scheme, which progressively updates the network and the set of pseudo labels by turns. Extensive experimental results show that our proposed method outperforms other previous state-of-the-art SSDA methods.

Dual Encoder Fusion U-Net (DEFU-Net) for Cross-manufacturer Chest X-Ray Segmentation

Zhang Lipei, Aozhi Liu, Jing Xiao

Auto-TLDR; Inception Convolutional Neural Network with Dilation for Chest X-Ray Segmentation

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A number of methods based on the deep learning have been applied to medical image segmentation and have achieved state-of-the-art performance. The most famous technique is U-Net which has been used to many medical datasets including the Chest X-ray. Due to the importance of chest x- ray data in studying COVID-19, there is a demand for state-of- art models capable of precisely segmenting chest x-rays. In this paper, we propose a dual encoder fusion U-Net framework for Chest X-rays based on Inception Convolutional Neural Network with dilation, Densely Connected Recurrent Convolutional Neural Network, which is named DEFU-Net. The densely connected recurrent path extends the network deeper for facilitating context feature extraction. In order to increase the width of network and enrich representation of features, the inception blocks with dilation have been used. The inception blocks can capture globally and locally spatial information with various receptive fields to avoid information loss caused by max-pooling. Meanwhile, the features fusion of two path by summation preserve the context and the spatial information for decoding part. We applied this model in Chest X-ray dataset from two different manufacturers (Montgomery and Shenzhen hospital). The DEFU-Net achieves the better performance than basic U-Net, residual U-Net, BCDU- Net, R2U-Net and attention R2U-Net. This model approaches state-of-the-art in this mixed dataset. The open source code for this proposed framework is public available.

Do Not Treat Boundaries and Regions Differently: An Example on Heart Left Atrial Segmentation

Zhou Zhao, Elodie Puybareau, Nicolas Boutry, Thierry Geraud

Auto-TLDR; Attention Full Convolutional Network for Atrial Segmentation using ResNet-101 Architecture

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Atrial fibrillation is the most common heart rhythm disease. Due to a lack of understanding in matter of underlying atrial structures, current treatments are still not satisfying. Recently, with the popularity of deep learning, many segmentation methods based on fully convolutional networks have been proposed to analyze atrial structures, especially from late gadolinium-enhanced magnetic resonance imaging. However, two problems still occur: 1) segmentation results include the atrial-like background; 2) boundaries are very hard to segment. Most segmentation approaches design a specific network that mainly focuses on the regions, to the detriment of the boundaries. Therefore, this paper proposes an attention full convolutional network framework based on the ResNet-101 architecture, which focuses on boundaries as much as on regions. The additional attention module is added to have the network pay more attention on regions and then to reduce the impact of the misleading similarity of neighboring tissues. We also use a hybrid loss composed of a region loss and a boundary loss to treat boundaries and regions at the same time. We demonstrate the efficiency of the proposed approach on the MICCAI 2018 Atrial Segmentation Challenge public dataset.

Attention2AngioGAN: Synthesizing Fluorescein Angiography from Retinal Fundus Images Using Generative Adversarial Networks

Sharif Amit Kamran, Khondker Fariha Hossain, Alireza Tavakkoli, Stewart Lee Zuckerbrod

Auto-TLDR; Fluorescein Angiography from Fundus Images using Attention-based Generative Networks

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Fluorescein Angiography (FA) is a technique that employs the designated camera for Fundus photography incorporating excitation and barrier filters. FA also requires fluorescein dye that is injected intravenously, which might cause adverse effects ranging from nausea, vomiting to even fatal anaphylaxis. Currently, no other fast and non-invasive technique exists that can generate FA without coupling with Fundus photography. To eradicate the need for an invasive FA extraction procedure, we introduce an Attention-based Generative network that can synthesize Fluorescein Angiography from Fundus images. The proposed gan incorporates multiple attention based skip connections in generators and comprises novel residual blocks for both generators and discriminators. It utilizes reconstruction, feature-matching, and perceptual loss along with adversarial training to produces realistic Angiograms that is hard for experts to distinguish from real ones. Our experiments confirm that the proposed architecture surpasses recent state-of-the-art generative networks for fundus-to-angio translation task.

Dealing with Scarce Labelled Data: Semi-Supervised Deep Learning with Mix Match for Covid-19 Detection Using Chest X-Ray Images

Saúl Calderón Ramirez, Raghvendra Giri, Shengxiang Yang, Armaghan Moemeni, Mario Umaña, David Elizondo, Jordina Torrents-Barrena, Miguel A. Molina-Cabello

Auto-TLDR; Semi-supervised Deep Learning for Covid-19 Detection using Chest X-rays

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Coronavirus (Covid-19) is spreading fast, infecting people through contact in various forms including droplets from sneezing and coughing. Therefore, the detection of infected subjects in an early, quick and cheap manner is urgent. Currently available tests are scarce and limited to people in danger of serious illness. The application of deep learning to chest X-ray images for Covid-19 detection is an attractive approach. However, this technology usually relies on the availability of large labelled datasets, a requirement hard to meet in the context of a virus outbreak. To overcome this challenge, a semi-supervised deep learning model using both labelled and unlabelled data is proposed. We developed and tested a semi-supervised deep learning framework based on the Mix Match architecture to classify chest X-rays into Covid-19, pneumonia and healthy cases. The presented approach was calibrated using two publicly available datasets. The results show an accuracy increase of around $15\%$ under low labelled / unlabelled data ratio. This indicates that our semi-supervised framework can help improve performance levels towards Covid-19 detection when the amount of high-quality labelled data is scarce. Also, we introduce a semi-supervised deep learning boost coefficient which is meant to ease the scalability of our approach and performance comparison.

Efficient Shadow Detection and Removal Using Synthetic Data with Domain Adaptation

Rui Guo, Babajide Ayinde, Hao Sun

Auto-TLDR; Shadow Detection and Removal with Domain Adaptation and Synthetic Image Database

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In recent years, learning based shadow detection and removal approaches have shown prospects and, in most cases, yielded state-of-the-art results. The performance of these approaches, however, relies heavily on the construction of training database of shadow images, shadow-free versions, and shadow maps as ground truth. This conventional data gathering method is time-consuming, expensive, or even practically intractable to realize especially for outdoor scenes with complicated shadow patterns, thus limiting the size of the data available for training. In this paper, we leverage on large high quality synthetic image database and domain adaptation to eliminate the bottlenecks resulting from insufficient training samples and domain bias. Specifically, our approach utilizes adversarial training to predict near-pixel-perfect shadow map from synthetic shadow image for downstream shadow removal steps. At inference time, we capitalize on domain adaptation via image style transfer to map the style of real- world scene to that of synthetic scene for the purpose of detecting and subsequently removing shadow. Comprehensive experiments indicate that our approach outperforms state-of-the-art methods on select benchmark datasets.

Energy-Constrained Self-Training for Unsupervised Domain Adaptation

Xiaofeng Liu, Xiongchang Liu, Bo Hu, Jun Lu, Jonghye Woo, Jane You

Auto-TLDR; Unsupervised Domain Adaptation with Energy Function Minimization

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Unsupervised domain adaptation (UDA) aims to transfer the knowledge on a labeled source domain distribution to perform well on an unlabeled target domain. Recently, the deep self-training involves an iterative process of predicting on the target domain and then taking the confident predictions as hard pseudo-labels for retraining. However, the pseudo-labels are usually unreliable, and easily leading to deviated solutions with propagated errors. In this paper, we resort to the energy-based model and constrain the training of the unlabeled target sample with the energy function minimization objective. It can be applied as a simple additional regularization. In this framework, it is possible to gain the benefits of the energy-based model, while retaining strong discriminative performance following a plug-and-play fashion. The convergence property and its connection with classification expectation minimization are investigated. We deliver extensive experiments on the most popular and large scale UDA benchmarks of image classification as well as semantic segmentation to demonstrate its generality and effectiveness.

Joint Supervised and Self-Supervised Learning for 3D Real World Challenges

Antonio Alliegro, Davide Boscaini, Tatiana Tommasi

Auto-TLDR; Self-supervision for 3D Shape Classification and Segmentation in Point Clouds

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Point cloud processing and 3D shape understanding are very challenging tasks for which deep learning techniques have demonstrated great potentials. Still further progresses are essential to allow artificial intelligent agents to interact with the real world. In many practical conditions the amount of annotated data may be limited and integrating new sources of knowledge becomes crucial to support autonomous learning. Here we consider several scenarios involving synthetic and real world point clouds where supervised learning fails due to data scarcity and large domain gaps. We propose to enrich standard feature representations by leveraging self-supervision through a multi-task model that can solve a 3D puzzle while learning the main task of shape classification or part segmentation. An extensive analysis investigating few-shot, transfer learning and cross-domain settings shows the effectiveness of our approach with state-of-the-art results for 3D shape classification and part segmentation.

A Transformer-Based Network for Anisotropic 3D Medical Image Segmentation

Guo Danfeng, Demetri Terzopoulos

Auto-TLDR; A transformer-based model to tackle the anisotropy problem in 3D medical image analysis

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A critical challenge of applying neural networks to 3D medical image analysis is to deal with the anisotropy problem. The inter-slice contextual information contained in medical images is important, especially when the structural information of lesions is needed. However, such information often varies with cases because of variable slice spacing. Image anisotropy downgrades model performance especially when slice spacing varies significantly among training and testing datasets. ExsiWe proposed a transformer-based model to tackle the anisotropy problem. It is adaptable to different levels of anisotropy and is computationally efficient. Experiments are conducted on 3D lung cancer segmentation task. Our model achieves an average Dice score of approximately 0.87, which generally outperforms baseline models.

Teacher-Student Competition for Unsupervised Domain Adaptation

Ruixin Xiao, Zhilei Liu, Baoyuan Wu

Auto-TLDR; Unsupervised Domain Adaption with Teacher-Student Competition

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With the supervision from source domain only in class-level, existing unsupervised domain adaption (UDA) methods mainly learn the domain-invariant representations from a shared feature extractor, which cause the source-bias problem. This paper proposes an unsupervised domain adaption approach with Teacher-Student Competition (TSC). In particular, a student network is introduced to learn the target-specific feature space, and we design a novel competition mechanism to select more credible pseudo-labels for the training of student network. We introduce a teacher network with the structure of existing conventional UDA method, and both teacher and student networks compete to provide target pseudo-labels to constrain every target sample's training in student network. Extensive experiments demonstrate that our proposed TSC framework significantly outperforms the state-of-the-art domain adaption methods on Office-31 and ImageCLEF-DA benchmarks.

Self-Supervised Domain Adaptation with Consistency Training

Liang Xiao, Jiaolong Xu, Dawei Zhao, Zhiyu Wang, Li Wang, Yiming Nie, Bin Dai

Auto-TLDR; Unsupervised Domain Adaptation for Image Classification

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We consider the problem of unsupervised domain adaptation for image classification. To learn target-domain-aware features from the unlabeled data, we create a self-supervised pretext task by augmenting the unlabeled data with a certain type of transformation (specifically, image rotation) and ask the learner to predict the properties of the transformation. However, the obtained feature representation may contain a large amount of irrelevant information with respect to the main task. To provide further guidance, we force the feature representation of the augmented data to be consistent with that of the original data. Intuitively, the consistency introduces additional constraints to representation learning, therefore, the learned representation is more likely to focus on the right information about the main task. Our experimental results validate the proposed method and demonstrate state-of-the-art performance on classical domain adaptation benchmarks.

Enlarging Discriminative Power by Adding an Extra Class in Unsupervised Domain Adaptation

Hai Tran, Sumyeong Ahn, Taeyoung Lee, Yung Yi

Auto-TLDR; Unsupervised Domain Adaptation using Artificial Classes

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We study the problem of unsupervised domain adaptation that aims at obtaining a prediction model for the target domain using labeled data from the source domain and unlabeled data from the target domain. There exists an array of recent research based on the idea of extracting features that are not only invariant for both domains but also provide high discriminative power for the target domain. In this paper, we propose an idea of improving the discriminativeness: Adding an extra artificial class and training the model on the given data together with the GAN-generated samples of the new class. The trained model based on the new class samples is capable of extracting the features that are more discriminative by repositioning data of current classes in the target domain and therefore increasing the distances among the target clusters in the feature space. Our idea is highly generic so that it is compatible with many existing methods such as DANN, VADA, and DIRT-T. We conduct various experiments for the standard data commonly used for the evaluation of unsupervised domain adaptations and demonstrate that our algorithm achieves the SOTA performance for many scenarios.

Mask-Based Style-Controlled Image Synthesis Using a Mask Style Encoder

Jaehyeong Cho, Wataru Shimoda, Keiji Yanai

Auto-TLDR; Style-controlled Image Synthesis from Semantic Segmentation masks using GANs

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In recent years, the advances in Generative Adversarial Networks (GANs) have shown impressive results for image generation and translation tasks. In particular, the image-to-image translation is a method of learning mapping from a source domain to a target domain and synthesizing an image. Image-to-image translation can be applied to a variety of tasks, making it possible to quickly and easily synthesize realistic images from semantic segmentation masks. However, in the existing image-to-image translation method, there is a limitation on controlling the style of the translated image, and it is not easy to synthesize an image by controlling the style of each mask element in detail. Therefore, we propose an image synthesis method that controls the style of each element by improving the existing image-to-image translation method. In the proposed method, we implement a style encoder that extracts style features for each mask element. The extracted style features are concatenated to the semantic mask in the normalization layer, and used the style-controlled image synthesis of each mask element. In experiments, we train style-controlled images synthesis using the datasets consisting of semantic segmentation masks and real images. The results show that the proposed method has excellent performance for style-controlled images synthesis for each element.

GAP: Quantifying the Generative Adversarial Set and Class Feature Applicability of Deep Neural Networks

Edward Collier, Supratik Mukhopadhyay

Auto-TLDR; Approximating Adversarial Learning in Deep Neural Networks Using Set and Class Adversaries

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Recent work in deep neural networks has sought to characterize the nature in which a network learns features and how applicable learnt features are to various problem sets. Deep neural network applicability can be split into three sub-problems; set applicability, class applicability, and instance applicability. In this work we seek to quantify the applicability of features learned during adversarial training, focusing specifically on set and class applicability. We apply techniques for measuring applicability to both generators and discriminators trained on various data sets to quantify applicability and better observe how both a generator and a discriminator, and generative models as a whole, learn features during adversarial training.

DE-Net: Dilated Encoder Network for Automated Tongue Segmentation

Hui Tang, Bin Wang, Jun Zhou, Yongsheng Gao

Auto-TLDR; Automated Tongue Image Segmentation using De-Net

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Automated tongue recognition is a growing research field due to global demand for personal health care. Using mobile devices to take tongue pictures is convenient and of low cost for tongue recognition. It is particularly suitable for self-health evaluation of the public. However, images taken by mobile devices are easily affected by various imaging environment, which makes fine segmentation a more challenging task compared with those taken by specialized acquisition devices. Deep learning approaches are promising for tongue image segmentation because they have powerful feature learning and representation capability. However, the successive pooling operations in these methods lead to loss of information on image details, making them fail when segmenting low-quality images captured by mobile devices. To address this issue, we propose a dilated encoder network (DE-Net) to capture more high-level features and get high-resolution output for automated tongue image segmentation. In addition, we construct two tongue image datasets which contain images taken by specialized devices and mobile devices, respectively, to verify the effectiveness of the proposed method. Experimental results on both datasets demonstrate that the proposed method outperforms the state-of-the-art methods in tongue image segmentation.

DARN: Deep Attentive Refinement Network for Liver Tumor Segmentation from 3D CT Volume

Yao Zhang, Jiang Tian, Cheng Zhong, Yang Zhang, Zhongchao Shi, Zhiqiang He

Auto-TLDR; Deep Attentive Refinement Network for Liver Tumor Segmentation from 3D Computed Tomography Using Multi-Level Features

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Automatic liver tumor segmentation from 3D Computed Tomography (CT) is a necessary prerequisite in the interventions of hepatic abnormalities and surgery planning. However, accurate liver tumor segmentation remains challenging due to the large variability of tumor sizes and inhomogeneous texture. Recent advances based on Fully Convolutional Network (FCN) in liver tumor segmentation draw on success of learning discriminative multi-level features. In this paper, we propose a Deep Attentive Refinement Network (DARN) for improved liver tumor segmentation from CT volumes by fully exploiting both low and high level features embedded in different layers of FCN. Different from existing works, we exploit attention mechanism to leverage the relation of different levels of features encoded in different layers of FCN. Specifically, we introduce a Semantic Attention Refinement (SemRef) module to selectively emphasize global semantic information in low level features with the guidance of high level ones, and a Spatial Attention Refinement (SpaRef) module to adaptively enhance spatial details in high level features with the guidance of low level ones. We evaluate our network on the public MICCAI 2017 Liver Tumor Segmentation Challenge dataset (LiTS dataset) and it achieves state-of-the-art performance. The proposed refinement modules are an effective strategy to exploit multi-level features and has great potential to generalize to other medical image segmentation tasks.

OCT Image Segmentation Using NeuralArchitecture Search and SRGAN

Saba Heidari, Omid Dehzangi, Nasser M. Nasarabadi, Ali Rezai

Auto-TLDR; Automatic Segmentation of Retinal Layers in Optical Coherence Tomography using Neural Architecture Search

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Alzheimer’s disease (AD) diagnosis is one of the major research areas in computational medicine. Optical coherence tomography (OCT) is a non-invasive, inexpensive, and timely efficient method that scans the human’s retina with depth. It has been hypothesized that the thickness of the retinal layers extracted from OCTs could be an efficient and effective biomarker for early diagnosis of AD. In this work, we aim to design a self-training model architecture for the task of segmenting the retinal layers in OCT scans. Neural architecture search (NAS) is a subfield of AutoML domain, which has a significant impact on improving the accuracy of machine vision tasks. We integrate the NAS algorithm with a Unet auto-encoder architecture as its backbone. Then, we employ our proposed model to segment the retinal nerve fiber layer in our preprocessed OCT images with the aim of AD diagnosis. In this work, we trained a super-resolution generative adversarial network on the raw OCT scans to improve the quality of the images before the modeling stage. In our architecture search strategy, different primitive operations suggested to find down- \& up-sampling Unet cell blocks and the binary gate method has been applied to make the search strategy more practical. Our architecture search method is empirically evaluated by training on the Unet and NAS-Unet from scratch. Specifically, the proposed NAS-Unet training significantly outperforms the baseline human-designed architecture by achieving 95.1\% in the mean Intersection over Union metric and 79.1\% in the Dice similarity coefﬁcient.

Detail-Revealing Deep Low-Dose CT Reconstruction

Xinchen Ye, Yuyao Xu, Rui Xu, Shoji Kido, Noriyuki Tomiyama

Auto-TLDR; A Dual-branch Aggregation Network for Low-Dose CT Reconstruction

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Low-dose CT imaging emerges with low radiation risk due to the reduction of radiation dose, but brings negative impact on the imaging quality. This paper addresses the problem of low-dose CT reconstruction. Previous methods are unsatisfactory due to the inaccurate recovery of image details under the strong noise generated by the reduction of radiation dose, which directly affects the final diagnosis. To suppress the noise effectively while retain the structures well, we propose a detail-revealing dual-branch aggregation network to effectively reconstruct the degraded CT image. Specifically, the main reconstruction branch iteratively exploits and compensates the reconstruction errors to gradually refine the CT image, while the prior branch is to learn the structure details as prior knowledge to help recover the CT image. A sophisticated detail-revealing loss is designed to fuse the information from both branches and guide the learning to obtain better performance from pixel-wise and holistic perspectives respectively. Experimental results show that our method outperforms the state-of-art methods in both PSNR and SSIM metrics.

Fine-Tuning Convolutional Neural Networks: A Comprehensive Guide and Benchmark Analysis for Glaucoma Screening

Amed Mvoulana, Rostom Kachouri, Mohamed Akil

Auto-TLDR; Fine-tuning Convolutional Neural Networks for Glaucoma Screening

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This work aimed at giving a comprehensive and in-detailed guide on the route to fine-tuning Convolutional Neural Networks (CNNs) for glaucoma screening. Transfer learning consists in a promising alternative to train CNNs from stratch, to avoid the huge data and resources requirements. After a thorough study of five state-of-the-art CNNs architectures, a complete and well-explained strategy for fine-tuning these networks is proposed, using hyperparameter grid-searching and two-phase training approach. Excellent performance is reached on model evaluation, with a 0.9772 AUROC validation rate, giving arise to reliable glaucoma diagosis-help systems. Also, a benchmark analysis is conducted across all fine-tuned models, studying them according to performance indices such as model complexity and size, AUROC density and inference time. This in-depth analysis allows a rigorous comparison between model characteristics, and is useful for giving practioners important trademarks for prospective applications and deployments.

Triplet-Path Dilated Network for Detection and Segmentation of General Pathological Images

Jiaqi Luo, Zhicheng Zhao, Fei Su, Limei Guo

Auto-TLDR; Triplet-path Network for One-Stage Object Detection and Segmentation in Pathological Images

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Deep learning has been widely applied in the field of medical image processing. However, compared with flourishing visual tasks in natural images, the progress achieved in pathological images is not remarkable, and detection and segmentation, which are among basic tasks of computer vision, are regarded as two independent tasks. In this paper, we make full use of existing datasets and construct a triplet-path network using dilated convolutions to cooperatively accomplish one-stage object detection and nuclei segmentation for general pathological images. First, in order to meet the requirement of detection and segmentation, a novel structure called triplet feature generation (TFG) is designed to extract high-resolution and multiscale features, where features from different layers can be properly integrated. Second, considering that pathological datasets are usually small, a location-aware and partially truncated loss function is proposed to improve the classification accuracy of datasets with few images and widely varying targets. We compare the performance of both object detection and instance segmentation with state-of-the-art methods. Experimental results demonstrate the effectiveness and efficiency of the proposed network on two datasets collected from multiple organs.

Aerial Road Segmentation in the Presence of Topological Label Noise

Corentin Henry, Friedrich Fraundorfer, Eleonora Vig

Auto-TLDR; Improving Road Segmentation with Noise-Aware U-Nets for Fine-Grained Topology delineation

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The availability of large-scale annotated datasets has enabled Fully-Convolutional Neural Networks to reach outstanding performance on road extraction in aerial images. However, high-quality pixel-level annotation is expensive to produce and even manually labeled data often contains topological errors. Trading off quality for quantity, many datasets rely on already available yet noisy labels, for example from OpenStreetMap. In this paper, we explore the training of custom U-Nets built with ResNet and DenseNet backbones using noise-aware losses that are robust towards label omission and registration noise. We perform an extensive evaluation of standard and noise-aware losses, including a novel Bootstrapped DICE-Coefficient loss, on two challenging road segmentation benchmarks. Our losses yield a consistent improvement in overall extraction quality and exhibit a strong capacity to cope with severe label noise. Our method generalizes well to two other fine-grained topology delineation tasks: surface crack detection for quality inspection and cell membrane extraction in electron microscopy imagery.