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A General End-To-End Method for Characterizing Neuropsychiatric Disorders Using Free-Viewing Visual Scanning Tasks

Hong Yue Sean Liu, Jonathan Chung, Moshe Eizenman

Auto-TLDR; A general, data-driven, end-to-end framework that extracts relevant features of attentional bias from visual scanning behaviour and uses these features

Abstract Slides Poster

The growing availability of eye-gaze tracking technology has allowed for its employment in a wide variety of applications, one of which is the objective diagnosis and monitoring of neuropsychiatric disorders from features of attentional bias extracted from visual scanning patterns. Current techniques in this field are largely comprised of non-generalizable methodologies that rely on domain expertise and study-specific assumptions. In this paper, we present a general, data-driven, end-to-end framework that extracts relevant features of attentional bias from visual scanning behaviour and uses these features to classify between subject groups with standard machine learning techniques. During the free-viewing task, subjects view sets of slides with thematic images while their visual scanning patterns (sets of ordered fixations) are monitored by an eye-tracking system. We encode fixations into relative visual attention maps (RVAMs) to describe measurement errors, and two data-driven methods are proposed to segment regions of interests from RVAMs: 1) using group average RVAMs, and 2) using difference of group average RVAMs. Relative fixation times within regions of interest are calculated and used as input features for a vanilla multilayered perceptron to classify between patient groups. The methods were evaluated on data from an anorexia nervosa (AN) study with 37 subjects and a bipolar/major depressive disorder (BD-MDD) study with 73 subjects. Using leave-one-subject-out cross validation, our technique is able to achieve an area under the receiver operating curve (AUROC) score of 0.935 for the AN study and 0.888 for the BD-MDD study, the latter of which exceeds the performance of the state-of-the-art analysis model designed specifically for the BD-MDD study, which had an AUROC of 0.879. The results validate the proposed methods' efficacy as generalizable, standard baselines for analyzing visual scanning data.

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Classifying Eye-Tracking Data Using Saliency Maps

Shafin Rahman, Sejuti Rahman, Omar Shahid, Md. Tahmeed Abdullah, Jubair Ahmed Sourov

Auto-TLDR; Saliency-based Feature Extraction for Automatic Classification of Eye-tracking Data

Abstract Slides Poster Similar

A plethora of research in the literature shows how human eye fixation pattern varies depending on different factors, including genetics, age, social functioning, cognitive functioning, and so on. Analysis of these variations in visual attention has already elicited two potential research avenues: 1) determining the physiological or psychological state of the subject and 2) predicting the tasks associated with the act of viewing from the recorded eye-fixation data. To this end, this paper proposes a visual saliency based novel feature extraction method for automatic and quantitative classification of eye-tracking data, which is applicable to both of the research directions. Instead of directly extracting features from the fixation data, this method employs several well-known computational models of visual attention to predict eye fixation locations as saliency maps. Comparing the saliency amplitudes, similarity and dissimilarity of saliency maps with the corresponding eye fixations maps gives an extra dimension of information which is effectively utilized to generate discriminative features to classify the eye-tracking data. Extensive experimentation using Saliency4ASD [1], Age Prediction [2], and Visual Perceptual Task [3] dataset show that our saliency-based feature can achieve superior performance, outperforming the previous state-of-the-art methods [2],[4], [5] by a considerable margin. Moreover, unlike the existing application-specific solutions, our method demonstrates performance improvement across three distinct problems from the real-life domain: Autism Spectrum Disorder screening, toddler age prediction, and human visual perceptual task classification, providing a general paradigm that utilizes the extra-information inherent in saliency maps for a more accurate classification.

Fully Convolutional Neural Networks for Raw Eye Tracking Data Segmentation, Generation, and Reconstruction

Wolfgang Fuhl, Yao Rong, Enkelejda Kasneci

Auto-TLDR; Semantic Segmentation of Eye Tracking Data with Fully Convolutional Neural Networks

Abstract Slides Poster Similar

In this paper, we use fully convolutional neural networks for the semantic segmentation of eye tracking data. We also use these networks for reconstruction, and in conjunction with a variational auto-encoder to generate eye movement data. The first improvement of our approach is that no input window is necessary, due to the use of fully convolutional networks and therefore any input size can be processed directly. The second improvement is that the used and generated data is raw eye tracking data (position X, Y and time) without preprocessing. This is achieved by pre-initializing the filters in the first layer and by building the input tensor along the z axis. We evaluated our approach on three publicly available datasets and compare the results to the state of the art.

GazeMAE: General Representations of Eye Movements Using a Micro-Macro Autoencoder

Louise Gillian C. Bautista, Prospero Naval

Auto-TLDR; Fast and Slow Eye Movement Representations for Sentiment-agnostic Eye Tracking

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Eye movements are intricate and dynamic events that contain a wealth of information about the subject and the stimuli. We propose an abstract representation of eye movements that preserve the important nuances in gaze behavior while being stimuli-agnostic. We consider eye movements as raw position and velocity signals and train a deep temporal convolutional autoencoder to learn micro-scale and macro-scale representations corresponding to the fast and slow features of eye movements. These joint representations are evaluated by fitting a linear classifier on various tasks and outperform other works in biometrics and stimuli classification. Further experiments highlight the validity and generalizability of this method, bringing eye tracking research closer to real-world applications.

Collaborative Human Machine Attention Module for Character Recognition

Chetan Ralekar, Tapan Gandhi, Santanu Chaudhury

Auto-TLDR; A Collaborative Human-Machine Attention Module for Deep Neural Networks

Abstract Slides Poster Similar

The deep learning models which include attention mechanisms are shown to enhance the performance and efficiency of the various computer vision tasks such as pattern recognition, object detection, face recognition, etc. Although the visual attention mechanism is the source of inspiration for these models, recent attention models consider `attention' as a pure machine vision optimization problem and visual attention remains the most neglected aspect. Therefore, this paper presents a collaborative human and machine attention module which considers both visual and network's attention. The proposed module is inspired by the dorsal (`where') pathways of visual processing and it can be integrated with any convolutional neural network (CNN) model. First, the module computes the spatial attention map from the input feature maps which is then combined with the visual attention maps. The visual attention maps are created using eye-fixations obtained by performing an eye-tracking experiment with human participants. The visual attention map covers the highly salient and discriminative image regions as humans tend to focus on such regions, whereas the other relevant image regions are processed by spatial attention map. The combination of these two maps results in the finer refinement in feature maps which results in improved performance. The comparative analysis reveals that our model not only shows significant improvement over the baseline model but also outperforms the other models. We hope that our findings using a collaborative human-machine attention module will be helpful in other vision tasks as well.

User-Independent Gaze Estimation by Extracting Pupil Parameter and Its Mapping to the Gaze Angle

Sang Yoon Han, Nam Ik Cho

Auto-TLDR; Gaze Point Estimation using Pupil Shape for Generalization

Abstract Slides Poster Similar

Since gaze estimation plays a crucial role in recognizing human intentions, it has been researched for a long time, and its accuracy is ever increasing. However, due to the wide variation in eye shapes and focusing abilities between the individuals, accuracies of most algorithms vary depending on each person in the test group, especially when the initial calibration is not well performed. To alleviate the user-dependency, we attempt to derive features that are general for most people and use them as the input to a deep network instead of using the images as the input. Specifically, we use the pupil shape as the core feature because it is directly related to the 3D eyeball rotation, and thus the gaze direction. While existing deep learning methods learn the gaze point by extracting various features from the image, we focus on the mapping function from the eyeball rotation to the gaze point by using the pupil shape as the input. It is shown that the accuracy of gaze point estimation also becomes robust for the uncalibrated points by following the characteristics of the mapping function. Also, our gaze network learns the gaze difference to facilitate the re-calibration process to fix the calibration-drift problem that typically occurs with glass-type or head-mount devices.

Detection and Correspondence Matching of Corneal Reflections for Eye Tracking Using Deep Learning

Soumil Chugh, Braiden Brousseau, Jonathan Rose, Moshe Eizenman

Auto-TLDR; A Fully Convolutional Neural Network for Corneal Reflection Detection and Matching in Extended Reality Eye Tracking Systems

Abstract Slides Poster Similar

Eye tracking systems that estimate the point-of-gaze are essential in extended reality (XR) systems as they enable new interaction paradigms and technological improvements. It is important for these systems to maintain accuracy when the headset moves relative to the head (known as device slippage) due to head movements or user adjustment. One of the most accurate eye tracking techniques, which is also insensitive to shifts of the system relative to the head, uses two or more infrared (IR) light emitting diodes to illuminate the eye and an IR camera to capture images of the eye. An essential step in estimating the point-of-gaze in these systems is the precise determination of the location of two or more corneal reflections (virtual images of the IR-LEDs that illuminate the eye) in images of the eye. Eye trackers tend to have multiple light sources to ensure at least one pair of reflections for each gaze position. The use of multiple light sources introduces a difficult problem: the need to match the corneal reflections with the corresponding light source over the range of expected eye movements. Corneal reflection detection and matching often fail in XR systems due to the proximity of camera and steep illumination angles of light sources with respect to the eye. The failures are caused by corneal reflections having varying shape and intensity levels or disappearance due to rotation of the eye, or the presence of spurious reflections. We have developed a fully convolutional neural network, based on the UNET architecture, that solves the detection and matching problem in the presence of spurious and missing reflections. Eye images of 25 people were collected in a virtual reality headset using a binocular eye tracking module consisting of five infrared light sources per eye. A set of 4,000 eye images were manually labelled for each of the corneal reflections, and data augmentation was used to generate a dataset of 40,000 images. The network is able to correctly identify and match 91% of corneal reflections present in the test set. This is comparable to a state-of-the-art deep learning system, but our approach requires 33 times less memory and executes 10 times faster. The proposed algorithm, when used in an eye tracker in a VR system, achieved an average mean absolute gaze error of 1°. This is a significant improvement over the state-of-the-art learning-based XR eye tracking systems that have reported gaze errors of 2-3°.

Exploring Spatial-Temporal Representations for fNIRS-based Intimacy Detection via an Attention-enhanced Cascade Convolutional Recurrent Neural Network

Chao Li, Qian Zhang, Ziping Zhao

Auto-TLDR; Intimate Relationship Prediction by Attention-enhanced Cascade Convolutional Recurrent Neural Network Using Functional Near-Infrared Spectroscopy

Abstract Slides Poster Similar

The detection of intimacy plays a crucial role in the improvement of intimate relationship, which contributes to promote the family and social harmony. Previous studies have shown that different degrees of intimacy have significant differences in brain imaging. Recently, a few of work has emerged to recognise intimacy automatically by using machine learning technique. Moreover, considering the temporal dynamic characteristics of intimacy relationship on neural mechanism, how to model spatio-temporal dynamics for intimacy prediction effectively is still a challenge. In this paper, we propose a novel method to explore deep spatial-temporal representations for intimacy prediction by Attention-enhanced Cascade Convolutional Recurrent Neural Network (ACCRNN). Given the advantages of time-frequency resolution in complex neuronal activities analysis, this paper utilizes functional near-infrared spectroscopy (fNIRS) to analyse and infer to intimate relationship. We collect a fNIRS-based dataset for the analysis of intimate relationship. Forty-two-channel fNIRS signals are recorded from the 44 subjects' prefrontal cortex when they watched a total of 18 photos of lovers, friends and strangers for 30 seconds per photo. The experimental results show that our proposed method outperforms the others in terms of accuracy with the precision of 96.5%. To the best of our knowledge, this is the first time that such a hybrid deep architecture has been employed for fNIRS-based intimacy prediction.

Prediction of Obstructive Coronary Artery Disease from Myocardial Perfusion Scintigraphy using Deep Neural Networks

Ida Arvidsson, Niels Christian Overgaard, Miguel Ochoa Figueroa, Jeronimo Rose, Anette Davidsson, Kalle Åström, Anders Heyden

Auto-TLDR; A Deep Learning Algorithm for Multi-label Classification of Myocardial Perfusion Scintigraphy for Stable Ischemic Heart Disease

Abstract Slides Poster Similar

For diagnosis and risk assessment in patients with stable ischemic heart disease, myocardial perfusion scintigraphy is one of the most common cardiological examinations performed today. There are however many motivations for why an artificial intelligence algorithm would provide useful input to this task. For example to reduce the subjectiveness and save time for the nuclear medicine physicians working with this time consuming task. In this work we have developed a deep learning algorithm for multi-label classification based on a modified convolutional neural network to estimate probability of obstructive coronary artery disease in the left anterior artery, left circumflex artery and right coronary artery. The prediction is based on data from myocardial perfusion scintigraphy studies conducted in a dedicated Cadmium-Zinc-Telluride cardio camera (D-SPECT Spectrum Dynamics). Data from 588 patients was available, with stress images in both upright and supine position, as well as a number of auxiliary parameters such as angina symptoms and BMI. The data was used to train and evaluate the algorithm using 5-fold cross-validation. We achieve state-of-the-art results for this task with an area under the receiver operating characteristics curve of 0.89 as average on per-vessel level and 0.94 on per-patient level.

Deep Transfer Learning for Alzheimer’s Disease Detection

Nicole Cilia, Claudio De Stefano, Francesco Fontanella, Claudio Marrocco, Mario Molinara, Alessandra Scotto Di Freca

Auto-TLDR; Automatic Detection of Handwriting Alterations for Alzheimer's Disease Diagnosis using Dynamic Features

Abstract Slides Poster Similar

Early detection of Alzheimer’s Disease (AD) is essential in order to initiate therapies that can reduce the effects of such a disease, improving both life quality and life expectancy of patients. Among all the activities carried out in our daily life, handwriting seems one of the first to be influenced by the arise of neurodegenerative diseases. For this reason, the analysis of handwriting and the study of its alterations has become of great interest in this research field in order to make a diagnosis as early as possible. In recent years, many studies have tried to use classification algorithms applied to handwritings to implement decision support systems for AD diagnosis. A key issue for the use of these techniques is the detection of effective features, that allow the system to distinguish the natural handwriting alterations due to age, from those caused by neurodegenerative disorders. In this context, many interesting results have been published in the literature in which the features have been typically selected by hand, generally considering the dynamics of the handwriting process in order to detect motor disorders closely related to AD. Features directly derived from handwriting generation models can be also very helpful for AD diagnosis. It should be remarked, however, that the above features do not consider changes in the shape of handwritten traces, which may occur as a consequence of neurodegenerative diseases, as well as the correlation among shape alterations and changes in the dynamics of the handwriting process. Moving from these considerations, the aim of this study is to verify if the combined use of both shape and dynamic features allows a decision support system to improve performance for AD diagnosis. To this purpose, starting from a database of on-line handwriting samples, we generated for each of them a synthetic off-line colour image, where the colour of each elementary trait encodes, in the three RGB channels, the dynamic information associated to that trait. Finally, we exploited the capability of Deep Neural Networks (DNN) to automatically extract features from raw images. The experimental comparison of the results obtained by using standard features and features extracted according the above procedure, confirmed the effectiveness of our approach.

Responsive Social Smile: A Machine-Learning Based Multimodal Behavior Assessment Framework towards Early Stage Autism Screening

Yueran Pan, Kunjing Cai, Ming Cheng, Xiaobing Zou, Ming Li

Auto-TLDR; Responsive Social Smile: A Machine Learningbased Assessment Framework for Early ASD Screening

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which causes social deﬁcits in social lives. Early ASD screening for children is an important method to reduce the impact of ASD on people’s whole lives. Traditional screening methods rely on protocol experiments and subjective evaluations from clinicians and domain experts and thereby cost a lot. To standardize the process of ASD screening, we 1 collaborate with a group of ASD experts, and design a ”Responsive Social Smile” protocol and an experiment environment. Also, we propose a machine learningbased assessment framework for early ASD screening. By integrating technologies of speech recognition and computer vision, the framework can quantitatively analyze the behaviors of children under well-designed protocols. By collecting 196 test samples from 41 children in the clinical treatments, our proposed method obtains 85.20% accuracy for the score prediction of individual protocol, and 80.49% unweighted accuracy for the ﬁnal ASD prediction. This result indicates that our model reaches the average level of domain experts in ASD diagnosis.

From Early Biological Models to CNNs: Do They Look Where Humans Look?

Marinella Iole Cadoni, Andrea Lagorio, Enrico Grosso, Jia Huei Tan, Chee Seng Chan

Auto-TLDR; Comparing Neural Networks to Human Fixations for Semantic Learning

Abstract Slides Poster Similar

Early hierarchical computational visual models as well as recent deep neural networks have been inspired by the functioning of the primate visual cortex system. Although much effort has been made to dissect neural networks to visualize the features they learn at the individual units, the scope of the visualizations has been limited to a categorization of the features in terms of their semantic level. Considering the ability humans have to select high semantic level regions of a scene, the question whether neural networks can match this ability, and if similarity with humans attention is correlated with neural networks performance naturally arise. To address this question we propose a pipeline to select and compare sets of feature points that maximally activate individual networks units to human fixations. We extract features from a variety of neural networks, from early hierarchical models such as HMAX up to recent deep convolutional neural netwoks such as Densnet, to compare them to human fixations. Experiments over the ETD database show that human fixations correlate with CNNs features from deep layers significantly better than with random sets of points, while they do not with features extracted from the first layers of CNNs, nor with the HMAX features, which seem to have low semantic level compared with the features that respond to the automatically learned filters of CNNs. It also turns out that there is a correlation between CNN’s human similarity and classification performance.

Classify Breast Histopathology Images with Ductal Instance-Oriented Pipeline

Beibin Li, Ezgi Mercan, Sachin Mehta, Stevan Knezevich, Corey Arnold, Donald Weaver, Joann Elmore, Linda Shapiro

Auto-TLDR; DIOP: Ductal Instance-Oriented Pipeline for Diagnostic Classification

Abstract Slides Poster Similar

In this study, we propose the Ductal Instance-Oriented Pipeline (DIOP) that contains a duct-level instance segmentation model, a tissue-level semantic segmentation model, and three-levels of features for diagnostic classification. Based on recent advancements in instance segmentation and the Mask R-CNN model, our duct-level segmenter tries to identify each ductal individual inside a microscopic image; then, it extracts tissue-level information from the identified ductal instances. Leveraging three levels of information obtained from these ductal instances and also the histopathology image, the proposed DIOP outperforms previous approaches (both feature-based and CNN-based) in all diagnostic tasks; for the four-way classification task, the DIOP achieves comparable performance to general pathologists in this unique dataset. The proposed DIOP only takes a few seconds to run in the inference time, which could be used interactively on most modern computers. More clinical explorations are needed to study the robustness and generalizability of this system in the future.

Quantified Facial Temporal-Expressiveness Dynamics for Affect Analysis

Md Taufeeq Uddin, Shaun Canavan

Auto-TLDR; quantified facial Temporal-expressiveness Dynamics for quantified affect analysis

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The quantification of visual affect data (e.g. face images) is essential to build and monitor automated affect modeling systems efficiently. Considering this, this work proposes quantified facial Temporal-expressiveness Dynamics (TED) to quantify the expressiveness of human faces. The proposed algorithm leverages multimodal facial features by incorporating static and dynamic information to enable accurate measurements of facial expressiveness. We show that TED can be used for high-level tasks such as summarization of unstructured visual data, expectation from and interpretation of automated affect recognition models. To evaluate the positive impact of using TED, a case study was conducted on spontaneous pain using the UNBC-McMaster spontaneous shoulder pain dataset. Experimental results show the efficacy of using TED for quantified affect analysis.

Estimation of Clinical Tremor Using Spatio-Temporal Adversarial AutoEncoder

Li Zhang, Vidya Koesmahargyo, Isaac Galatzer-Levy

Auto-TLDR; ST-AAE: Spatio-temporal Adversarial Autoencoder for Clinical Assessment of Hand Tremor Frequency and Severity

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Collecting sufficient well-labeled training data is a challenging task in many clinical applications. Besides the tremendous efforts required for data collection, clinical assessments are also impacted by raters’ variabilities, which may be significant even among experienced clinicians. The high demands of reproducible and scalable data-driven approaches in these areas necessitates relevant research on learning with limited data. In this work, we propose a spatio-temporal adversarial autoencoder (ST-AAE) for clinical assessment of hand tremor frequency and severity. The ST-AAE integrates spatial and temporal information simultaneously into the original AAE, taking optical flows as inputs. Using only optical flows, irrelevant background or static objects from RGB frames are largely eliminated, so that the AAE is directed to effectively learn key feature representations of the latent space from tremor movements. The ST-AAE was evaluated with both volunteer and clinical data. The volunteer results showed that the ST-AAE improved model performance significantly by 15% increase on accuracy. Leave-one-out (on subjects) cross validation was used to evaluate the accuracy for all the 3068 video segments from 28 volunteers. The weighted average of the AUCs of ROCs is 0.97. The results demonstrated that the ST-AAE model, trained with a small number of subjects, can be generalized well to different subjects. In addition, the model trained only by volunteer data was also evaluated with 32 clinical videos from 9 essential tremor patients, the model predictions correlate well with the clinical ratings: correlation coefficient r = 0.91 and 0.98 for in-person ratings and video watching ratings, respectively.

FastSal: A Computationally Efficient Network for Visual Saliency Prediction

Feiyan Hu, Kevin Mcguinness

Auto-TLDR; MobileNetV2: A Convolutional Neural Network for Saliency Prediction

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This paper focuses on the problem of visual saliency prediction, predicting regions of an image that tend to attract human visual attention, under a constrained computational budget. We modify and test various recent efficient convolutional neural network architectures like EfficientNet and MobileNetV2 and compare them with existing state-of-the-art saliency models such as SalGAN and DeepGaze II both in terms of standard accuracy metrics like AUC and NSS, and in terms of the computational complexity and model size. We find that MobileNetV2 makes an excellent backbone for a visual saliency model and can be effective even without a complex decoder. We also show that knowledge transfer from a more computationally expensive model like DeepGaze II can be achieved via pseudo-labelling an unlabelled dataset, and that this approach gives result on-par with many state-of-the-art algorithms with a fraction of the computational cost and model size.

A Deep Learning Approach for the Segmentation of Myocardial Diseases

Khawala Brahim, Abdull Qayyum, Alain Lalande, Arnaud Boucher, Anis Sakly, Fabrice Meriaudeau

Auto-TLDR; Segmentation of Myocardium Infarction Using Late GADEMRI and SegU-Net

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Cardiac left ventricular (LV) segmentation is of paramount essential step for both diagnosis and treatment of cardiac pathologies such as ischemia, myocardial infarction, arrhythmia and myocarditis. However, this segmentation is challenging due to high variability across patients and the potential lack of contrast between structures. In this work, we propose and evaluate a (2.5D) SegU-Net model based on the fusion of two deep learning techniques (U-Net and Seg-Net) for automated LGEMRI (Late gadolinium enhanced magnetic resonance imaging) myocardial disease (infarct core and no reflow region) quantification in a new multifield expert annotated dataset. Given that the scar tissue represents a small part of the whole MRI slices, we focused on myocardium area. Segmentation results show that this preprocessing step facilitate the learning procedure. In order to solve the class imbalance problem, we propose to apply the Jaccard loss and the Focal Loss as optimization loss function and to integrate a class weights strategy into the objective function. Late combination has been used to merge the output of the best trained models on a different set of hyperparameters. The final network segmentation performances will be useful for future comparison of new method to the current related work for this task. A total number of 2237 of slices (320 cases) were used for training/validation and 210 slices (35 cases) were used for testing. Experiments over our proposed dataset, using several evaluation metrics such Jaccard distance (IOU), Accuracy and Dice similarity coefficient (DSC), demonstrate efficiency performance in quantifying different zones of myocardium infarction across various patients. As compared to the second intra-observer study, our testing results showed that the SegUNet prediction model leads to these average dice coefficients over all segmented tissue classes, respectively : 'Background': 0.99999, 'Myocardium': 0.99434, 'Infarctus': 0.95587, 'Noreflow': 0.78187.

Automatic Classification of Human Granulosa Cells in Assisted Reproductive Technology Using Vibrational Spectroscopy Imaging

Marina Paolanti, Emanuele Frontoni, Giorgia Gioacchini, Giorgini Elisabetta, Notarstefano Valentina, Zacà Carlotta, Carnevali Oliana, Andrea Borini, Marco Mameli

Auto-TLDR; Predicting Oocyte Quality in Assisted Reproductive Technology Using Machine Learning Techniques

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In the field of reproductive technology, the biochemical composition of female gametes has been successfully investigated with the use of vibrational spectroscopy. Currently, in assistive reproductive technology (ART), there are no shared criteria for the choice of oocyte, and automatic classification methods for the best quality oocytes have not yet been applied. In this paper, considering the lack of criteria in Assisted Reproductive Technology (ART), we use Machine Learning (ML) techniques to predict oocyte quality for a successful pregnancy. To improve the chances of successful implantation and minimize any complications during the pregnancy, Fourier transform infrared microspectroscopy (FTIRM) analysis has been applied on granulosa cells (GCs) collected along with the oocytes during oocyte aspiration, as it is routinely done in ART, and specific spectral biomarkers were selected by multivariate statistical analysis. A proprietary biological reference dataset (BRD) was successfully collected to predict the best oocyte for a successful pregnancy. Personal health information are stored, maintained and backed up using a cloud computing service. Using a user-friendly interface, the user will evaluate whether or not the selected oocyte will have a positive result. This interface includes a dashboard for retrospective analysis, reporting, real-time processing, and statistical analysis. The experimental results are promising and confirm the efficiency of the method in terms of classification metrics: precision, recall, and F1-score (F1) measures.

Utilising Visual Attention Cues for Vehicle Detection and Tracking

Feiyan Hu, Venkatesh Gurram Munirathnam, Noel E O'Connor, Alan Smeaton, Suzanne Little

Auto-TLDR; Visual Attention for Object Detection and Tracking in Driver-Assistance Systems

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Advanced Driver-Assistance Systems (ADAS) have been attracting attention from many researchers. Vision based sensors are the closest way to emulate human driver visual behavior while driving. In this paper, we explore possible ways to use visual attention (saliency) for object detection and tracking. We investigate: 1) How a visual attention map such as a subjectness attention or saliency map and an objectness attention map can facilitate region proposal generation in a 2-stage object detector; 2) How a visual attention map can be used for tracking multiple objects. We propose a neural network that can simultaneously detect objects as and generate objectness and subjectness maps to save computational power. We further exploit the visual attention map during tracking using a sequential Monte Carlo probability hypothesis density (PHD) filter. The experiments are conducted on KITTI and DETRAC datasets. The use of visual attention and hierarchical features has shown a considerable improvement of≈8% in object detection which effectively increased tracking performance by≈4% on KITTI dataset.

Self-Supervised Learning with Graph Neural Networks for Region of Interest Retrieval in Histopathology

Yigit Ozen, Selim Aksoy, Kemal Kosemehmetoglu, Sevgen Onder, Aysegul Uner

Auto-TLDR; Self-supervised Contrastive Learning for Deep Representation Learning of Histopathology Images

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Deep learning has achieved successful performance in representation learning and content-based retrieval of histopathology images. The commonly used setting in deep learning-based approaches is supervised training of deep neural networks for classification, and using the trained model to extract representations that are used for computing and ranking the distances between images. However, there are two remaining major challenges. First, supervised training of deep neural networks requires large amount of manually labeled data which is often limited in the medical field. Transfer learning has been used to overcome this challenge, but its success remained limited. Second, the clinical practice in histopathology necessitates working with regions of interest (ROI) of multiple diagnostic classes with arbitrary shapes and sizes. The typical solution to this problem is to aggregate the representations of fixed-sized patches cropped from these regions to obtain region-level representations. However, naive methods cannot sufficiently exploit the rich contextual information in the complex tissue structures. To tackle these two challenges, we propose a generic method that utilizes graph neural networks (GNN), combined with a self-supervised training method using a contrastive loss. GNN enables representing arbitrarily-shaped ROIs as graphs and encoding contextual information. Self-supervised contrastive learning improves quality of learned representations without requiring labeled data. The experiments using a challenging breast histopathology data set show that the proposed method achieves better performance than the state-of-the-art.

Assessing the Severity of Health States Based on Social Media Posts

Shweta Yadav, Joy Prakash Sain, Amit Sheth, Asif Ekbal, Sriparna Saha, Pushpak Bhattacharyya

Auto-TLDR; A Multiview Learning Framework for Assessment of Health State in Online Health Communities

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The unprecedented growth of Internet users has resulted in an abundance of unstructured information on social media including health forums, where patients request health-related information or opinions from other users. Previous studies have shown that online peer support has limited effectiveness without expert intervention. Therefore, a system capable of assessing the severity of health state from the patients' social media posts can help health professionals (HP) in prioritizing the user’s post. In this study, we inspect the efficacy of different aspects of Natural Language Understanding (NLU) to identify the severity of the user’s health state in relation to two perspectives(tasks) (a) Medical Condition (i.e., Recover, Exist, Deteriorate, Other) and (b) Medication (i.e., Effective, Ineffective, Serious Adverse Effect, Other) in online health communities. We propose a multiview learning framework that models both the textual content as well as contextual-information to assess the severity of the user’s health state. Specifically, our model utilizes the NLU views such as sentiment, emotions, personality, and use of figurative language to extract the contextual information. The diverse NLU views demonstrate its effectiveness on both the tasks and as well as on the individual disease to assess a user’s health.

Automatic Tuberculosis Detection Using Chest X-Ray Analysis with Position Enhanced Structural Information

Hermann Jepdjio Nkouanga, Szilard Vajda

Auto-TLDR; Automatic Chest X-ray Screening for Tuberculosis in Rural Population using Localized Region on Interest

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For Tuberculosis (TB) detection beside the more expensive diagnosis solutions such as culture or sputum smear analysis one could consider the automatic analysis of the chest X-ray (CXR). This could mimic the lung region reading by the radiologist and it could provide a cheap solution to analyze and diagnose pulmonary abnormalities such as TB which often co- occurs with HIV. This software based pulmonary screening can be a reliable and affordable solution for rural population in different parts of the world such as India, Africa, etc. Our fully automatic system is processing the incoming CXR image by applying image processing techniques to detect the region on interest (ROI) followed by a computationally cheap feature extraction involving edge detection using Laplacian of Gaussian which we enrich by counting the local distribution of the intensities. The choice to ”zoom in” the ROI and look for abnormalities locally is motivated by the fact that some pulmonary abnormalities are localized in specific regions of the lungs. Later on the classifiers can decide about the normal or abnormal nature of each lung X-ray. Our goal is to find a simple feature, instead of a combination of several ones, -proposed and promoted in recent years’ literature, which can properly describe the different pathological alterations in the lungs. Our experiments report results on two publicly available data collections1, namely the Shenzhen and the Montgomery collection. For performance evaluation, measures such as area under the curve (AUC), and accuracy (ACC) were considered, achieving AUC = 0.81 (ACC = 83.33%) and AUC = 0.96 (ACC = 96.35%) for the Montgomery and Schenzen collections, respectively. Several comparisons are also provided to other state- of-the-art systems reported recently in the field.

Using Machine Learning to Refer Patients with Chronic Kidney Disease to Secondary Care

Lee Au-Yeung, Xianghua Xie, Timothy Marcus Scale, James Anthony Chess

Auto-TLDR; A Machine Learning Approach for Chronic Kidney Disease Prediction using Blood Test Data

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There has been growing interest recently in using machine learning techniques as an aid in clinical medicine. Machine learning offers a range of classification algorithms which can be applied to medical data to aid in making clinical predictions. Recent studies have demonstrated the high predictive accuracy of various classification algorithms applied to clinical data. Several studies have already been conducted in diagnosing or predicting chronic kidney disease at various stages using different sets of variables. In this study we are investigating the use machine learning techniques with blood test data. Such a system could aid renal teams in making recommendations to primary care general practitioners to refer patients to secondary care where patients may benefit from earlier specialist assessment and medical intervention. We are able to achieve an overall accuracy of 88.48\% using logistic regression, 87.12\% using ANN and 85.29\% using SVM. ANNs performed with the highest sensitivity at 89.74\% compared to 86.67\% for logistic regression and 85.51\% for SVM.

Tensor Factorization of Brain Structural Graph for Unsupervised Classification in Multiple Sclerosis

Berardino Barile, Marzullo Aldo, Claudio Stamile, Françoise Durand-Dubief, Dominique Sappey-Marinier

Auto-TLDR; A Fully Automated Tensor-based Algorithm for Multiple Sclerosis Classification based on Structural Connectivity Graph of the White Matter Network

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Analysis of longitudinal changes in brain diseases is essential for a better characterization of pathological processes and evaluation of the prognosis. This is particularly important in Multiple Sclerosis (MS) which is the first traumatic disease in young adults, with unknown etiology and characterized by complex inflammatory and degenerative processes leading to different clinical courses. In this work, we propose a fully automated tensor-based algorithm for the classification of MS clinical forms based on the structural connectivity graph of the white matter (WM) network. Using non-negative tensor factorization (NTF), we first focused on the detection of pathological patterns of the brain WM network affected by significant longitudinal variations. Second, we performed unsupervised classification of different MS phenotypes based on these longitudinal patterns, and finally, we used the latent factors obtained by the factorization algorithm to identify the most affected brain regions.

A Novel Computer-Aided Diagnostic System for Early Assessment of Hepatocellular Carcinoma

Ahmed Alksas, Mohamed Shehata, Gehad Saleh, Ahmed Shaffie, Ahmed Soliman, Mohammed Ghazal, Hadil Abukhalifeh, Abdel Razek Ahmed, Ayman El-Baz

Auto-TLDR; Classification of Liver Tumor Lesions from CE-MRI Using Structured Structural Features and Functional Features

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Early assessment of liver cancer patients with hepatocellular carcinoma (HCC) is of immense importance to provide the proper treatment plan. In this paper, we have developed a two-stage classification computer-aided diagnostic (CAD) system that has the ability to detect and grade the liver observations from multiphase contrast enhanced magnetic resonance imaging (CE-MRI). The proposed approach consists of three main steps. First, a pre-processing is applied to the CE-MRI scans to delineate the tumor lesions that will be used as an ROI across the four different phases of the CE-MRI, (namely, the pre-contrast, late-arterial, portal-venous, and delayed-contrast). Second, a group of three features are modeled to provide a quantitative discrimination between the tumor lesions; namely: i) the tumor appearance that is modeled using a set of texture features, (namely; the first-order histogram, second-order gray-level co-occurrence matrix, and second-order gray-level run-length matrix), to capture any discrimination that may appear in the lesion texture, ii) the spherical harmonics (SH) based shape features that have the ability to describe the shape complexity of the liver tumors, and iii) the functional features that are based on the calculation of the wash-in/wash-out through that evaluate the intensity changes across the post-contrast phases. Finally, the aforementioned individual features were then integrated together to obtain the combined features to be fed to a machine learning classifier towards getting the final diagnostic decision. The proposed CAD system has been tested using hepatic observations that was obtained from 85 participating patients, 34 patients with benign tumors, 34 patients with intermediate tumors and 34 with malignant tumors. Using a random forests based classifier with a leave-one-subject-out (LOSO) cross-validation, the developed CAD system achieved an 87.1% accuracy in distinguishing the malignant, intermediate and benign tumors. The classification performance is then evaluated using k-fold (5/10-fold) cross-validation approach to examine the robustness of the system. The LR-1 lesions were classified from LR-2 benign lesions with 91.2% accuracy, while 85.3% accuracy was achieved differentiating between LR-4 and LR-5 malignant tumors. The obtained results hold a promise of the proposed framework to be reliably used as a noninvasive diagnostic tool for the early detection and grading of liver cancer tumors.

Supporting Skin Lesion Diagnosis with Content-Based Image Retrieval

Stefano Allegretti, Federico Bolelli, Federico Pollastri, Sabrina Longhitano, Giovanni Pellacani, Costantino Grana

Auto-TLDR; Skin Images Retrieval Using Convolutional Neural Networks for Skin Lesion Classification and Segmentation

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Given the relevance of skin cancer, many attempts have been dedicated to the creation of automated devices that could assist both expert and beginner dermatologists towards fast and early diagnosis of skin lesions. In recent years, tasks such as skin lesion classification and segmentation have been extensively addressed with deep learning algorithms, which in some cases reach a diagnostic accuracy comparable to that of expert physicians. However, the general lack of interpretability and reliability severely hinders the ability of those approaches to actually support dermatologists in the diagnosis process. In this paper a novel skin images retrieval system is presented, which exploits features extracted by Convolutional Neural Networks to gather similar images from a publicly available dataset, in order to assist the diagnosis process of both expert and novice practitioners. In the proposed framework, Resnet-50 is initially trained for the classification of dermoscopic images; then, the feature extraction part is isolated, and an embedding network is build on top of it. The embedding learns an alternative representation, which allows to check image similarity by means of a distance measure. Experimental results reveal that the proposed method is able to select meaningful images, which can effectively boost the classification accuracy of human dermatologists.

Electroencephalography Signal Processing Based on Textural Features for Monitoring the Driver’s State by a Brain-Computer Interface

Giulia Orrù, Marco Micheletto, Fabio Terranova, Gian Luca Marcialis

Auto-TLDR; One-dimensional Local Binary Pattern Algorithm for Estimating Driver Vigilance in a Brain-Computer Interface System

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In this study we investigate a textural processing method of electroencephalography (EEG) signal as an indicator to estimate the driver's vigilance in a hypothetical Brain-Computer Interface (BCI) system. The novelty of the solution proposed relies on employing the one-dimensional Local Binary Pattern (1D-LBP) algorithm for feature extraction from pre-processed EEG data. From the resulting feature vector, the classification is done according to three vigilance classes: awake, tired and drowsy. The claim is that the class transitions can be detected by describing the variations of the micro-patterns' occurrences along the EEG signal. The 1D-LBP is able to describe them by detecting mutual variations of the signal temporarily "close" as a short bit-code. Our analysis allows to conclude that the 1D-LBP adoption has led to significant performance improvement. Moreover, capturing the class transitions from the EEG signal is effective, although the overall performance is not yet good enough to develop a BCI for assessing the driver's vigilance in real environments.

Planar 3D Transfer Learning for End to End Unimodal MRI Unbalanced Data Segmentation

Martin Kolarik, Radim Burget, Carlos M. Travieso-Gonzalez, Jan Kocica

Auto-TLDR; Planar 3D Res-U-Net Network for Unbalanced 3D Image Segmentation using Fluid Attenuation Inversion Recover

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We present a novel approach of 2D to 3D transfer learning based on mapping pre-trained 2D convolutional neural network weights into planar 3D kernels. The method is validated by proposed planar 3D res-u-net network with encoder transferred from the 2D VGG-16 which is applied for a single-stage unbalanced 3D image data segmentation. In particular, we evaluate the method on the MICCAI 2016 MS lesion segmentation challenge dataset utilizing solely Fluid Attenuation Inversion Recover (FLAIR) sequence without brain extraction for training and inference to simulate real medical praxis. The planar 3D res-u-net network performed the best both in sensitivity and Dice score amongst end to end methods processing raw MRI scans and achieved comparable Dice score to a state-of-the-art unimodal not end to end approach. Complete source code was released under the open-source license and this paper is in compliance with the Machine learning Reproducibility Checklist. By implementing practical transfer learning for 3D data representation we were able to successfully segment heavily unbalanced data without selective sampling and achieved more reliable results using less training data in single modality. From medical perspective, the unimodal approach gives an advantage in real praxis as it does not require co-registration nor additional scanning time during examination. Although modern medical imaging methods capture high resolution 3D anatomy scans suitable for computer aided detection system processing, deployment of automatic systems for interpretation of radiology imaging is still rather theoretical in many medical areas. Our work aims to bridge the gap offering solution for partial research questions.

A Benchmark Dataset for Segmenting Liver, Vasculature and Lesions from Large-Scale Computed Tomography Data

Bo Wang, Zhengqing Xu, Wei Xu, Qingsen Yan, Liang Zhang, Zheng You

Auto-TLDR; The Biggest Treatment-Oriented Liver Cancer Dataset for Segmentation

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How to build a high-performance liver-related computer assisted diagnosis system is an open question of great interest. However, the performance of the state-of-art algorithm is always limited by the amount of data and quality of the label. To address this problem, we propose the biggest treatment-oriented liver cancer dataset for liver surgery and treatment planning. This dataset provides 216 cases (totally about 268K frames) scanned images in contrast-enhanced computed tomography (CT). We labeled all the CT images with the liver, liver vasculature and liver tumor segmentation ground truth for train and tune segmentation algorithms in advance. Based on that, we evaluate several recent and state-of-the-art segmentation algorithms, including 7 deep learning methods, on CT sequences. All results are compared to reference segmentations five error metrics that highlight different aspects of segmentation accuracy. In general, compared with previous datasets, our dataset is really a challenging dataset. To our knowledge, the proposed dataset and benchmark allow for the first time systematic exploration of such issues, and will be made available to allow for further research in this field.

PrivAttNet: Predicting Privacy Risks in Images Using Visual Attention

Chen Zhang, Thivya Kandappu, Vigneshwaran Subbaraju

Auto-TLDR; PrivAttNet: A Visual Attention Based Approach for Privacy Sensitivity in Images

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Visual privacy concerns associated with image sharing is a critical issue that need to be addressed to enable safe and lawful use of online social platforms. Users of social media platforms often suffer from no guidance in sharing sensitive images in public, and often face with social and legal consequences. Given the recent success of visual attention based deep learning methods in measuring abstract phenomena like image memorability, we are motivated to investigate whether visual attention based methods could be useful in measuring psycho-physical phenomena like "privacy sensitivity". In this paper we propose PrivAttNet -- a visual attention based approach, that can be trained end-to-end to estimate the privacy sensitivity of images without explicitly detecting objects and attributes present in the image. We show that our PrivAttNet model outperforms various SOTA and baseline strategies -- a 1.6 fold reduction in $L1-error$ over SOTA and 7%--10% improvement in Spearman-rank correlation between the predicted and ground truth sensitivity scores. Additionally, the attention maps from PrivAttNet are found to be useful in directing the users to the regions that are responsible for generating the privacy risk score.

A Systematic Investigation on Deep Architectures for Automatic Skin Lesions Classification

Pierluigi Carcagni, Marco Leo, Andrea Cuna, Giuseppe Celeste, Cosimo Distante

Auto-TLDR; RegNet: Deep Investigation of Convolutional Neural Networks for Automatic Classification of Skin Lesions

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Computer vision-based techniques are more and more employed in healthcare and medical fields nowadays in order, principally, to be as a support to the experienced medical staff to help them to make a quick and correct diagnosis. One of the hot topics in this arena concerns the automatic classification of skin lesions. Several promising works exist about it, mainly leveraging Convolutional Neural Networks (CNN), but proposed pipeline mainly rely on complex data preprocessing and there is no systematic investigation about how available deep models can actually reach the accuracy needed for real applications. In order to overcome these drawbacks, in this work, an end-to-end pipeline is introduced and some of the most recent Convolutional Neural Networks (CNNs) architectures are included in it and compared on the largest common benchmark dataset recently introduced. To this aim, for the first time in this application context, a new network design paradigm, namely RegNet, has been exploited to get the best models among a population of configurations. The paper introduces a threefold level of contribution and novelty with respect the previous literature: the deep investigation of several CNN architectures driving to a consistent improvement of the lesions recognition accuracy, the exploitation of a new network design paradigm able to study the behavior of populations of models and a deep discussion about pro and cons of each analyzed method paving the path towards new research lines.

Translating Adult's Focus of Attention to Elderly's

Onkar Krishna, Go Irie, Takahito Kawanishi, Kunio Kashino, Kiyoharu Aizawa

Auto-TLDR; Elderly Focus of Attention Prediction Using Deep Image-to-Image Translation

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Predicting which part of a scene elderly people would pay attention to could be useful in assisting their daily activities, such as driving, walking, and searching. Many computational models for predicting focus of attention (FoA) have been developed. However, most of them focus on mimicking adult FoA and do not work well for predicting elderly's, due to age-related changes in human vision. Is it possible to leverage the prediction results made by an FoA model of general adults to accurately predict elderly's FoA, rather than training a new network from scratch? In this paper, we consider a novel problem of translating adult's FoA to elderly's and propose an approach based on deep image-to-image translation. Experimental results on two datasets covering both free-viewing and task-based viewing scenarios demonstrate that our model gives remarkable prediction accuracy compared to baselines.

Weight Estimation from an RGB-D Camera in Top-View Configuration

Marco Mameli, Marina Paolanti, Nicola Conci, Filippo Tessaro, Emanuele Frontoni, Primo Zingaretti

Auto-TLDR; Top-View Weight Estimation using Deep Neural Networks

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The development of so-called soft-biometrics aims at providing information related to the physical and behavioural characteristics of a person. This paper focuses on bodyweight estimation based on the observation from a top-view RGB-D camera. In fact, the capability to estimate the weight of a person can be of help in many different applications, from health-related scenarios to business intelligence and retail analytics. To deal with this issue, a TVWE (Top-View Weight Estimation) framework is proposed with the aim of predicting the weight. The approach relies on the adoption of Deep Neural Networks (DNNs) that have been trained on depth data. Each network has also been modified in its top section to replace classification with prediction inference. The performance of five state-of-art DNNs has been compared, namely VGG16, ResNet, Inception, DenseNet and Efficient-Net. In addition, a convolutional auto-encoder has also been included for completeness. Considering the limited literature in this domain, the TVWE framework has been evaluated on a new publicly available dataset: “VRAI Weight estimation Dataset”, which also collects, for each subject, labels related to weight, gender, and height. The experimental results have demonstrated that the proposed methods are suitable for this task, bringing different and significant insights for the application of the solution in different domains.

Spatial Bias in Vision-Based Voice Activity Detection

Kalin Stefanov, Mohammad Adiban, Giampiero Salvi

Auto-TLDR; Spatial Bias in Vision-based Voice Activity Detection in Multiparty Human-Human Interactions

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We present models for automatic vision-based voice activity detection (VAD) in multiparty human-human interactions that are aimed at complementing the acoustic VAD methods. We provide evidence that this type of vision-based VAD models are susceptible to spatial bias in the datasets. The physical settings of the interaction, usually constant throughout data acquisition, determines the distribution of head poses of the participants. Our results show that when the head pose distributions are significantly different in the training and test sets, the performance of the models drops significantly. This suggests that previously reported results on datasets with a fixed physical configuration may overestimate the generalization capabilities of this type of models. We also propose a number of possible remedies to the spatial bias, including data augmentation, input masking and dynamic features, and provide an in-depth analysis of the visual cues used by our models.

FMRI Brain Networks As Statistical Mechanical Ensembles

Jianjia Wang, Hui Wu, Edwin Hancock

Auto-TLDR; Microcanonical Ensemble Methods for FMRI Brain Networks for Alzheimer's Disease

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In this paper, we apply ensemble methods from statistical physics to analyse fMRI brain networks for Alzheimer's patients. By mapping the nodes in a network to virtual particles in a thermal system, the microcanonical ensemble and the canonical ensemble are analogous to two different fMRI network representations. These representations are obtained by selecting a threshold on the BOLD time series correlations between nodes in different ways. The microcanonical ensemble corresponds to a set of networks with a fixed fraction of edges, while the canonical ensemble corresponds to the set networks with edges obtained with a fixed value of the threshold. In the former case, there is zero variance in the number of edges in each network, while in the latter case the set of networks have a variance in the number of edges. Ensemble methods describe the macroscopic properties of a network by considering the underlying microscopic characterisations which are in turn closely related to the degree configuration and network entropy. Our treatment allows us to specify new partition functions for fMRI brain networks, and to explore a phase transition in the degree distribution. The resulting method turns out to be an effective tool to identify the most salient anatomical brain regions in Alzheimer's disease and provides a tool to distinguish groups of patients in different stages of the disease.

Confidence Calibration for Deep Renal Biopsy Immunofluorescence Image Classification

Federico Pollastri, Juan Maroñas, Federico Bolelli, Giulia Ligabue, Roberto Paredes, Riccardo Magistroni, Costantino Grana

Auto-TLDR; A Probabilistic Convolutional Neural Network for Immunofluorescence Classification in Renal Biopsy

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With this work we tackle immunofluorescence classification in renal biopsy, employing state-of-the-art Convolutional Neural Networks. In this setting, the aim of the probabilistic model is to assist an expert practitioner towards identifying the location pattern of antibody deposits within a glomerulus. Since modern neural networks often provide overconfident outputs, we stress the importance of having a reliable prediction, demonstrating that Temperature Scaling, a recently introduced re-calibration technique, can be successfully applied to immunofluorescence classification in renal biopsy. Experimental results demonstrate that the designed model yields good accuracy on the specific task, and that Temperature Scaling is able to provide reliable probabilities, which are highly valuable for such a task given the low inter-rater agreement.

Automatic Semantic Segmentation of Structural Elements related to the Spinal Cord in the Lumbar Region by Using Convolutional Neural Networks

Jhon Jairo Sáenz Gamboa, Maria De La Iglesia-Vaya, Jon Ander Gómez

Auto-TLDR; Semantic Segmentation of Lumbar Spine Using Convolutional Neural Networks

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This work addresses the problem of automatically segmenting the MR images corresponding to the lumbar spine. The purpose is to detect and delimit the different structural elements like vertebrae, intervertebral discs, nerves, blood vessels, etc. This task is known as semantic segmentation. The approach proposed in this work is based on convolutional neural networks whose output is a mask where each pixel from the input image is classified into one of the possible classes. Classes were defined by radiologists and correspond to structural elements and tissues. The proposed network architectures are variants of the U-Net. Several complementary blocks were used to define the variants: spatial attention models, deep supervision and multi-kernels at input, this last block type is based on the idea of inception. Those architectures which got the best results are described in this paper, and their results are discussed. Two of the proposed architectures outperform the standard U-Net used as baseline.

Automatic Annotation of Corpora for Emotion Recognition through Facial Expressions Analysis

Alex Mircoli, Claudia Diamantini, Domenico Potena, Emanuele Storti

Auto-TLDR; Automatic annotation of video subtitles on the basis of facial expressions using machine learning algorithms

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The recent diffusion of social networks has made available an unprecedented amount of user-generated content, which may be analyzed in order to determine people's opinions and emotions about a large variety of topics. Research has made many efforts in defining accurate algorithms for analyzing emotions expressed by users in texts; however, their performance often rely on the existence of large annotated datasets, whose current scarcity represents a major issue. The manual creation of such datasets represents a costly and time-consuming activity and hence there is an increasing demand for techniques for the automatic annotation of corpora. In this work we present a methodology for the automatic annotation of video subtitles on the basis of the analysis of facial expressions of people in videos, with the goal of creating annotated corpora that may be used to train emotion recognition algorithms. Facial expressions are analyzed through machine learning algorithms, on the basis of a set of manually-engineered facial features that are extracted from video frames. The soundness of the proposed methodology has been evaluated through an extensive experimentation aimed at determining the performance on real datasets of each methodological step.

EasiECG: A Novel Inter-Patient Arrhythmia Classification Method Using ECG Waves

Chuanqi Han, Ruoran Huang, Fang Yu, Xi Huang, Li Cui

Auto-TLDR; EasiECG: Attention-based Convolution Factorization Machines for Arrhythmia Classification

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Abstract—In an ECG record, the PQRST waves are of important medical significance which provide ample information reflecting heartbeat activities. In this paper, we propose a novel arrhythmia classification method namely EasiECG, characterized by simplicity and accuracy. Compared with other works, the EasiECG takes the configuration of these five key waves into account and does not require complicated feature engineering. Meanwhile, an additional encoding of the extracted features makes the EasiECG applicable even on samples with missing waves. To automatically capture interactions that contribute to the classification among the processed features, a novel adapted classification model named Attention-based Convolution Factorization Machines (ACFM) is proposed. In detail, the ACFM can learn both linear and high-order interactions from linear regression and convolution on outer-product feature interaction maps, respectively. After that, an attention mechanism implemented in the model can further assign different importance of these interactions when predicting certain types of heartbeats. To validate the effectiveness and practicability of our EasiECG, extensive experiments of inter-patient paradigm on the benchmark MIT-BIH arrhythmia database are conducted. To tackle the imbalanced sample problem in this dataset, an ingenious loss function: focal loss is adopted when training. The experiment results show that our method is competitive compared with other state-of-the-arts, especially in classifying the Supraventricular ectopic beats. Besides, the EasiECG achieves an overall accuracy of 87.6% on samples with a missing wave in the related experiment, demonstrating the robustness of our proposed method.

Saliency Prediction on Omnidirectional Images with Brain-Like Shallow Neural Network

Zhu Dandan, Chen Yongqing, Min Xiongkuo, Zhao Defang, Zhu Yucheng, Zhou Qiangqiang, Yang Xiaokang, Tian Han

Auto-TLDR; A Brain-like Neural Network for Saliency Prediction of Head Fixations on Omnidirectional Images

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Deep feedforward convolutional neural networks (CNNs) perform well in the saliency prediction of omnidirectional images (ODIs), and have become the leading class of candidate models of the visual processing mechanism in the primate ventral stream. These CNNs have evolved from shallow network architecture to extremely deep and branching architecture to achieve superb performance in various vision tasks, yet it is unclear how brain-like they are. In particular, these deep feedforward CNNs are difficult to mapping to ventral stream structure of the brain visual system due to their vast number of layers and missing biologically-important connections, such as recurrence. To tackle this issue, some brain-like shallow neural networks are introduced. In this paper, we propose a novel brain-like network model for saliency prediction of head fixations on ODIs. Specifically, our proposed model consists of three modules: a CORnet-S module, a template feature extraction module and a ranking attention module (RAM). The CORnet-S module is a lightweight artificial neural network (ANN) with four anatomically mapped areas (V1, V2, V4 and IT) and it can simulate the visual processing mechanism of ventral visual stream in the human brain. The template features extraction module is introduced to extract attention maps of ODIs and provide guidance for the feature ranking in the following RAM module. The RAM module is used to rank and select features that are important for fine-grained saliency prediction. Extensive experiments have validated the effectiveness of the proposed model in predicting saliency maps of ODIs, and the proposed model outperforms other state-of-the-art methods with similar scale.

Explainable Online Validation of Machine Learning Models for Practical Applications

Wolfgang Fuhl, Yao Rong, Thomas Motz, Michael Scheidt, Andreas Markus Hartel, Andreas Koch, Enkelejda Kasneci

Auto-TLDR; A Reformulation of Regression and Classification for Machine Learning Algorithm Validation

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We present a reformulation of the regression and classification, which aims to validate the result of a machine learning algorithm. Our reformulation simplifies the original problem and validates the result of the machine learning algorithm using the training data. Since the validation of machine learning algorithms must always be explainable, we perform our experiments with the kNN algorithm as well as with an algorithm based on conditional probabilities, which is proposed in this work. For the evaluation of our approach, three publicly available data sets were used and three classification and two regression problems were evaluated. The presented algorithm based on conditional probabilities is also online capable and requires only a fraction of memory compared to the kNN algorithm.

Detecting Marine Species in Echograms Via Traditional, Hybrid, and Deep Learning Frameworks

Porto Marques Tunai, Alireza Rezvanifar, Melissa Cote, Alexandra Branzan Albu, Kaan Ersahin, Todd Mudge, Stephane Gauthier

Auto-TLDR; End-to-End Deep Learning for Echogram Interpretation of Marine Species in Echograms

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This paper provides a comprehensive comparative study of traditional, hybrid, and deep learning (DL) methods for detecting marine species in echograms. Acoustic backscatter data obtained from multi-frequency echosounders is visualized as echograms and typically interpreted by marine biologists via manual or semi-automatic methods, which are time-consuming. Challenges related to automatic echogram interpretation are the variable size and acoustic properties of the biological targets (marine life), along with significant inter-class similarities. Our study explores and compares three types of approaches that cover the entire range of machine learning methods. Based on our experimental results, we conclude that an end-to-end DL-based framework, that can be readily scaled to accommodate new species, is overall preferable to other learning approaches for echogram interpretation, even when only a limited number of annotated training samples is available.

Dealing with Scarce Labelled Data: Semi-Supervised Deep Learning with Mix Match for Covid-19 Detection Using Chest X-Ray Images

Saúl Calderón Ramirez, Raghvendra Giri, Shengxiang Yang, Armaghan Moemeni, Mario Umaña, David Elizondo, Jordina Torrents-Barrena, Miguel A. Molina-Cabello

Auto-TLDR; Semi-supervised Deep Learning for Covid-19 Detection using Chest X-rays

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Coronavirus (Covid-19) is spreading fast, infecting people through contact in various forms including droplets from sneezing and coughing. Therefore, the detection of infected subjects in an early, quick and cheap manner is urgent. Currently available tests are scarce and limited to people in danger of serious illness. The application of deep learning to chest X-ray images for Covid-19 detection is an attractive approach. However, this technology usually relies on the availability of large labelled datasets, a requirement hard to meet in the context of a virus outbreak. To overcome this challenge, a semi-supervised deep learning model using both labelled and unlabelled data is proposed. We developed and tested a semi-supervised deep learning framework based on the Mix Match architecture to classify chest X-rays into Covid-19, pneumonia and healthy cases. The presented approach was calibrated using two publicly available datasets. The results show an accuracy increase of around $15\%$ under low labelled / unlabelled data ratio. This indicates that our semi-supervised framework can help improve performance levels towards Covid-19 detection when the amount of high-quality labelled data is scarce. Also, we introduce a semi-supervised deep learning boost coefficient which is meant to ease the scalability of our approach and performance comparison.

A Comparison of Neural Network Approaches for Melanoma Classification

Maria Frasca, Michele Nappi, Michele Risi, Genoveffa Tortora, Alessia Auriemma Citarella

Auto-TLDR; Classification of Melanoma Using Deep Neural Network Methodologies

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Melanoma is the deadliest form of skin cancer and it is diagnosed mainly visually, starting from initial clinical screening and followed by dermoscopic analysis, biopsy and histopathological examination. A dermatologist’s recognition of melanoma may be subject to errors and may take some time to diagnose it. In this regard, deep learning can be useful in the study and classification of skin cancer. In particular, by classifying images with Deep Neural Network methodologies, it is possible to obtain comparable or even superior results compared to those of dermatologists. In this paper, we propose a methodology for the classification of melanoma by adopting different deep learning techniques applied to a common dataset, composed of images from the ISIC dataset and consisting of different types of skin diseases, including melanoma on which we applied a specific pre-processing phase. In particular, a comparison of the results is performed in order to select the best effective neural network to be applied to the problem of recognition and classification of melanoma. Moreover, we also evaluate the impact of the pre- processing phase on the final classification. Different metrics such as accuracy, sensitivity, and specificity have been selected to assess the goodness of the adopted neural networks and compare them also with the manual classification of dermatologists.

MRP-Net: A Light Multiple Region Perception Neural Network for Multi-Label AU Detection

Yang Tang, Shuang Chen, Honggang Zhang, Gang Wang, Rui Yang

Auto-TLDR; MRP-Net: A Fast and Light Neural Network for Facial Action Unit Detection

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Facial Action Units (AUs) are of great significance in communication. Automatic AU detection can improve the understanding of psychological condition and emotional status. Recently, a number of deep learning methods have been proposed to take charge with problems in automatic AU detection. Several challenges, like unbalanced labels and ignorance of local information, remain to be addressed. In this paper, we propose a fast and light neural network called MRP-Net, which is an end-to-end trainable method for facial AU detection to solve these problems. First, we design a Multiple Region Perception (MRP) module aimed at capturing different locations and sizes of features in the deeper level of the network without facial landmark points. Then, in order to balance the positive and negative samples in the large dataset, a batch balanced method adjusting the weight of every sample in one batch in our loss function is suggested. Experimental results on two popular AU datasets, BP4D and DISFA prove that MRP-Net outperforms state-of-the-art methods. Compared with the best method, not only does MRP-Net have an average F1 score improvement of 2.95% on BP4D and 5.43% on DISFA, and it also decreases the number of network parameters by 54.62% and the number of network FLOPs by 19.6%.

Inferring Functional Properties from Fluid Dynamics Features

Andrea Schillaci, Maurizio Quadrio, Carlotta Pipolo, Marcello Restelli, Giacomo Boracchi

Auto-TLDR; Exploiting Convective Properties of Computational Fluid Dynamics for Medical Diagnosis

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In a wide range of applied problems involving fluid flows, Computational Fluid Dynamics (CFD) provides detailed quantitative information on the flow field, at various levels of fidelity and computational cost. However, CFD alone cannot predict high-level functional properties of the system that are not easily obtained from the equations of fluid motion. In this work, we present a data-driven framework to extract additional information, such as medical diagnostic output, from CFD solutions. The task is made difficult by the huge data dimensionality of CFD, together with the limited amount of training data implied by its high computational cost. By pursuing a traditional ML pipeline of pre-processing, feature extraction, and model training, we demonstrate that informative features can be extracted from CFD data. Two experiments, pertaining to different application domains, support the claim that the convective properties implicit into a CFD solution can be leveraged to retrieve functional information for which an analytical definition is missing. Despite the preliminary nature of our study and the relative simplicity of both the geometrical and CFD models, for the first time we demonstrate that the combination of ML and CFD can diagnose a complex system in terms of high-level functional information.

One Step Clustering Based on A-Contrario Framework for Detection of Alterations in Historical Violins

Alireza Rezaei, Sylvie Le Hégarat-Mascle, Emanuel Aldea, Piercarlo Dondi, Marco Malagodi

Auto-TLDR; A-Contrario Clustering for the Detection of Altered Violins using UVIFL Images

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Preventive conservation is an important practice in Cultural Heritage. The constant monitoring of the state of conservation of an artwork helps us reduce the risk of damage and number of interventions necessary. In this work, we propose a probabilistic approach for the detection of alterations on the surface of historical violins based on an a-contrario framework. Our method is a one step NFA clustering solution which considers grey-level and spatial density information in one background model. The proposed method is robust to noise and avoids parameter tuning and any assumption about the quantity of the worn out areas. We have used as input UV induced fluorescence (UVIFL) images for considering details not perceivable with visible light. Tests were conducted on image sequences included in the ``Violins UVIFL imagery'' dataset. Results illustrate the ability of the algorithm to distinguish the worn area from the surrounding regions. Comparisons with the state of the art clustering methods shows improved overall precision and recall.

Learning Emotional Blinded Face Representations

Alejandro Peña Almansa, Julian Fierrez, Agata Lapedriza, Aythami Morales

Auto-TLDR; Blind Face Representations for Emotion Recognition

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This work proposes two new face representations that are blind to the expressions associated to emotional responses. This work is in part motivated by new international regulations for personal data protection, which force data controllers to protect any kind of sensitive information involved in automatic processes. The advances in affective computing have contributed to improve human-machine interfaces, but at the same time, the capacity to monitorize emotional responses trigger potential risks for humans, both in terms of fairness and privacy. We propose two different methods to learn these facial expression blinded features. We show that it is possible to eliminate information related to emotion recognition tasks, while the performance of subject verification, gender recognition, and ethnicity classification are just slightly affected. We also present an application to train fairer classifiers over a protected facial expression attribute. The results demonstrate that it is possible to reduce emotional information in the face representation while retaining competitive performance in other face-based artificial intelligence tasks.

Understanding Integrated Gradients with SmoothTaylor for Deep Neural Network Attribution

Gary Shing Wee Goh, Sebastian Lapuschkin, Leander Weber, Wojciech Samek, Alexander Binder

Auto-TLDR; SmoothGrad: bridging Integrated Gradients and SmoothGrad from the Taylor's theorem perspective

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Integrated Gradients as an attribution method for deep neural network models offers simple implementability. However, it suffers from noisiness of explanations which affects the ease of interpretability. The SmoothGrad technique is proposed to solve the noisiness issue and smoothen the attribution maps of any gradient-based attribution method. In this paper, we present SmoothTaylor as a novel theoretical concept bridging Integrated Gradients and SmoothGrad, from the Taylor's theorem perspective. We apply the methods to the image classification problem, using the ILSVRC2012 ImageNet object recognition dataset, and a couple of pretrained image models to generate attribution maps. These attribution maps are empirically evaluated using quantitative measures for sensitivity and noise level. We further propose adaptive noising to optimize for the noise scale hyperparameter value. From our experiments, we find that the SmoothTaylor approach together with adaptive noising is able to generate better quality saliency maps with lesser noise and higher sensitivity to the relevant points in the input space as compared to Integrated Gradients.