Sparse Network Inversion for Key Instance Detection in Multiple Instance Learning

Beomjo Shin, Junsu Cho, Hwanjo Yu, Seungjin Choi

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Auto-TLDR; Improving Attention-based Deep Multiple Instance Learning for Key Instance Detection (KID)

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Multiple Instance Learning (MIL) involves predicting a single label for a bag of instances, given positive or negative labels at bag-level, without accessing to label for each instance in the training phase. Since a positive bag contains both positive and negative instances, it is often required to detect positive instances (key instances) when a set of instances is categorized as a positive bag. The attention-based deep MIL model is a recent advance in both bag-level classification and key instance detection (KID). However, if the positive and negative instances in a positive bag are not clearly distinguishable, the attention-based deep MIL model has limited KID performance as the attention scores are skewed to few positive instances. In this paper, we present a method to improve the attention-based deep MIL model in the task of KID. The main idea is to use the neural network inversion to find which instances made contribution to the bag-level prediction produced by the trained MIL model. Moreover, we incorporate a sparseness constraint into the neural network inversion, leading to the sparse network inversion which is solved by the proximal gradient method. Numerical experiments on an MNIST-based image MIL dataset and two real-world histopathology datasets verify the validity of our method, demonstrating the KID performance is significantly improved while the performance of bag-level prediction is maintained.

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Attention Based Multi-Instance Thyroid Cytopathological Diagnosis with Multi-Scale Feature Fusion

Shuhao Qiu, Yao Guo, Chuang Zhu, Wenli Zhou, Huang Chen

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Auto-TLDR; A weakly supervised multi-instance learning framework based on attention mechanism with multi-scale feature fusion for thyroid cytopathological diagnosis

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In recent years, deep learning has been popular in combining with cytopathology diagnosis. Using the whole slide images (WSI) scanned by electronic scanners at clinics, researchers have developed many algorithms to classify the slide (benign or malignant). However, the key area that support the diagnosis result can be relatively small in a thyroid WSI, and only the global label can be acquired, which make the direct use of the strongly supervised learning framework infeasible. What’s more, because the clinical diagnosis of the thyroid cells requires the use of visual features in different scales, a generic feature extraction way may not achieve good performance. In this paper, we propose a weakly supervised multi-instance learning framework based on attention mechanism with multi-scale feature fusion (MSF) using convolutional neural network (CNN) for thyroid cytopathological diagnosis. We take each WSI as a bag, each bag contains multiple instances which are the different regions of the WSI, our framework is trained to learn the key area automatically and make the classification. We also propose a feature fusion structure, merge the low-level features into the final feature map and add an instance-level attention module in it, which improves the classification accuracy. Our model is trained and tested on the collected clinical data, reaches the accuracy of 93.2%, which outperforms the other existing methods. We also tested our model on a public histopathology dataset and achieves better result than the state-of-the-art deep multi-instance method.

A New Convex Loss Function for Multiple Instance Support Vector Machines

Sang-Baeg Kim, Jung-Man Bae

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Auto-TLDR; WR-SVM: A Novel Multiple Instance SVM for Video Classification

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We develop a novel multiple instance SVM based on maximizing the minimum witness rate (WR) among positive bags. We solve this nonlinear integer programming problem by the multiple instance SVM formulation with a convex loss function, where unknown integer labels of instances in positive bags are relaxed to real numbers between -1 and 1 using the tanh(.) to estimate WR of a positive bag. Our new model, WR-SVM, also can incorporates the multiple instance learning (MIL) problem into a simple deep neural network framework with no additional MIL pooling layers. WR-SVM is robust to input perturbation by eliminating the imbalance between positive instances allocated to positive bags. A better generalization ability is expected by the large margin due to the balanced allocation of positive instances to positive bags. We perform experiments on various video datasets to verify the effectiveness of our method for video classification. The results of WR-SVM outperform the state-of-the-art for MIL-based video classification models.

Deep Multiple Instance Learning with Spatial Attention for ROP Case Classification, Instance Selection and Abnormality Localization

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Auto-TLDR; MIL-SA: Deep Multiple Instance Learning for Automated Screening of Retinopathy of Prematurity

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This paper tackles automated screening of Retinopathy of Prematurity (ROP), one of the most common causes of visual loss in childhood. Clinically, ROP screening per case requires multiple color fundus images capturing different zones of the premature retina. A desirable model shall not only make a decision at the case level, but also pinpoint which instances and what part of the instances are responsible for the decision. This paper makes the first attempt to accomplish three tasks, i.e, ROP case classification, instance selection and abnormality localization in a unified framework. To that end, we propose a new model that effectively combines instance-attention based deep multiple instance learning (MIL) and spatial attention (SA). The propose model, which we term MIL-SA, identifies positive instances in light of their contributions to case-level decision. Meanwhile, abnormal regions in the identified instances are automatically localized by the SA mechanism. Moreover, MIL-SA is learned from case-level binary labels exclusively, and in an end-to-end manner. Experiments on a large clinical dataset of 2,186 cases with 11,053 fundus images show the viability of the proposed model for all the three tasks.

DA-RefineNet: Dual-Inputs Attention RefineNet for Whole Slide Image Segmentation

Ziqiang Li, Rentuo Tao, Qianrun Wu, Bin Li

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Auto-TLDR; DA-RefineNet: A dual-inputs attention network for whole slide image segmentation

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Automatic medical image segmentation techniques have wide applications for disease diagnosing, however, its much more challenging than natural optical image segmentation tasks due to the high-resolution of medical images and the corresponding huge computation cost. Sliding window was a commonly used technique for whole slide image (WSI) segmentation, however, for these methods that based on sliding window, the main drawback was lacking of global contextual information for supervision. In this paper, we proposed a dual-inputs attention network (denoted as DA-RefineNet) for WSI segmentation, where both local fine-grained information and global coarse information can be efficiently utilized. Sufficient comparative experiments were conducted to evaluate the effectiveness of the proposed method, the results proved that the proposed method can achieve better performance on WSI segmentation tasks compared to methods rely on single-input.

Classify Breast Histopathology Images with Ductal Instance-Oriented Pipeline

Beibin Li, Ezgi Mercan, Sachin Mehta, Stevan Knezevich, Corey Arnold, Donald Weaver, Joann Elmore, Linda Shapiro

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Auto-TLDR; DIOP: Ductal Instance-Oriented Pipeline for Diagnostic Classification

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In this study, we propose the Ductal Instance-Oriented Pipeline (DIOP) that contains a duct-level instance segmentation model, a tissue-level semantic segmentation model, and three-levels of features for diagnostic classification. Based on recent advancements in instance segmentation and the Mask R-CNN model, our duct-level segmenter tries to identify each ductal individual inside a microscopic image; then, it extracts tissue-level information from the identified ductal instances. Leveraging three levels of information obtained from these ductal instances and also the histopathology image, the proposed DIOP outperforms previous approaches (both feature-based and CNN-based) in all diagnostic tasks; for the four-way classification task, the DIOP achieves comparable performance to general pathologists in this unique dataset. The proposed DIOP only takes a few seconds to run in the inference time, which could be used interactively on most modern computers. More clinical explorations are needed to study the robustness and generalizability of this system in the future.

Hierarchical Multimodal Attention for Deep Video Summarization

Melissa Sanabria, Frederic Precioso, Thomas Menguy

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Auto-TLDR; Automatic Summarization of Professional Soccer Matches Using Event-Stream Data and Multi- Instance Learning

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The way people consume sports on TV has drastically evolved in the last years, particularly under the combined effects of the legalization of sport betting and the huge increase of sport analytics. Several companies are nowadays sending observers in the stadiums to collect live data of all the events happening on the field during the match. Those data contain meaningful information providing a very detailed description of all the actions occurring during the match to feed the coaches and staff, the fans, the viewers, and the gamblers. Exploiting all these data, sport broadcasters want to generate extra content such as match highlights, match summaries, players and teams analytics, etc., to appeal subscribers. This paper explores the problem of summarizing professional soccer matches as automatically as possible using both the aforementioned event-stream data collected from the field and the content broadcasted on TV. We have designed an architecture, introducing first (1) a Multiple Instance Learning method that takes into account the sequential dependency among events and then (2) a hierarchical multimodal attention layer that grasps the importance of each event in an action. We evaluate our approach on matches from two professional European soccer leagues, showing its capability to identify the best actions for automatic summarization by comparing with real summaries made by human operators.

Stochastic Runge-Kutta Methods and Adaptive SGD-G2 Stochastic Gradient Descent

Gabriel Turinici, Imen Ayadi

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Auto-TLDR; Adaptive Stochastic Runge Kutta for the Minimization of the Loss Function

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The minimization of the loss function is of paramount importance in deep neural networks. Many popular optimization algorithms have been shown to correspond to some evolution equation of gradient flow type. Inspired by the numerical schemes used for general evolution equations, we introduce a second-order stochastic Runge Kutta method and show that it yields a consistent procedure for the minimization of the loss function. In addition, it can be coupled, in an adaptive framework, with the Stochastic Gradient Descent (SGD) to adjust automatically the learning rate of the SGD The resulting adaptive SGD, called SGD-G2, shows good results in terms of convergence speed when tested on standard data-sets.

IDA-GAN: A Novel Imbalanced Data Augmentation GAN

Hao Yang, Yun Zhou

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Auto-TLDR; IDA-GAN: Generative Adversarial Networks for Imbalanced Data Augmentation

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Self-Supervised Learning with Graph Neural Networks for Region of Interest Retrieval in Histopathology

Yigit Ozen, Selim Aksoy, Kemal Kosemehmetoglu, Sevgen Onder, Aysegul Uner

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Auto-TLDR; Self-supervised Contrastive Learning for Deep Representation Learning of Histopathology Images

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Deep learning has achieved successful performance in representation learning and content-based retrieval of histopathology images. The commonly used setting in deep learning-based approaches is supervised training of deep neural networks for classification, and using the trained model to extract representations that are used for computing and ranking the distances between images. However, there are two remaining major challenges. First, supervised training of deep neural networks requires large amount of manually labeled data which is often limited in the medical field. Transfer learning has been used to overcome this challenge, but its success remained limited. Second, the clinical practice in histopathology necessitates working with regions of interest (ROI) of multiple diagnostic classes with arbitrary shapes and sizes. The typical solution to this problem is to aggregate the representations of fixed-sized patches cropped from these regions to obtain region-level representations. However, naive methods cannot sufficiently exploit the rich contextual information in the complex tissue structures. To tackle these two challenges, we propose a generic method that utilizes graph neural networks (GNN), combined with a self-supervised training method using a contrastive loss. GNN enables representing arbitrarily-shaped ROIs as graphs and encoding contextual information. Self-supervised contrastive learning improves quality of learned representations without requiring labeled data. The experiments using a challenging breast histopathology data set show that the proposed method achieves better performance than the state-of-the-art.

Point In: Counting Trees with Weakly Supervised Segmentation Network

Pinmo Tong, Shuhui Bu, Pengcheng Han

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Auto-TLDR; Weakly Tree counting using Deep Segmentation Network with Localization and Mask Prediction

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For tree counting tasks, since traditional image processing methods require expensive feature engineering and are not end-to-end frameworks, this will cause additional noise and cannot be optimized overall, so this method has not been widely used in recent trends of tree counting application. Recently, many deep learning based approaches are designed for this task because of the powerful feature extracting ability. The representative way is bounding box based supervised method, but time-consuming annotations are indispensable for them. Moreover, these methods are difficult to overcome the occlusion or overlap. To solve this problem, we propose a weakly tree counting network (WTCNet) based on deep segmentation network with only point supervision. It can simultaneously complete tree counting with localization and output mask of each tree at the same time. We first adopt a novel feature extractor network (FENet) to get features of input images, and then an effective strategy is introduced to deal with different mask predictions. In the end, we propose a basic localization guidance accompany with rectification guidance to train the network. We create two different datasets and select an existing challenging plant dataset to evaluate our method on three different tasks. Experimental results show the good performance improvement of our method compared with other existing methods. Further study shows that our method has great potential to reduce human labor and provide effective ground-truth masks and the results show the superiority of our method over the advanced methods.

Neuron-Based Network Pruning Based on Majority Voting

Ali Alqahtani, Xianghua Xie, Ehab Essa, Mark W. Jones

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Auto-TLDR; Large-Scale Neural Network Pruning using Majority Voting

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The achievement of neural networks in a variety of applications is accompanied by a dramatic increase in computational costs and memory requirements. In this paper, we propose an efficient method to simultaneously identify the critical neurons and prune the model during training without involving any pre-training or fine-tuning procedures. Unlike existing methods, which accomplish this task in a greedy fashion, we propose a majority voting technique to compare the activation values among neurons and assign a voting score to quantitatively evaluate their importance.This mechanism helps to effectively reduce model complexity by eliminating the less influential neurons and aims to determine a subset of the whole model that can represent the reference model with much fewer parameters within the training process. Experimental results show that majority voting efficiently compresses the network with no drop in model accuracy, pruning more than 79\% of the original model parameters on CIFAR10 and more than 91\% of the original parameters on MNIST. Moreover, we show that with our proposed method, sparse models can be further pruned into even smaller models by removing more than 60\% of the parameters, whilst preserving the reference model accuracy.

Learning Sparse Deep Neural Networks Using Efficient Structured Projections on Convex Constraints for Green AI

Michel Barlaud, Frederic Guyard

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Auto-TLDR; Constrained Deep Neural Network with Constrained Splitting Projection

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In recent years, deep neural networks (DNN) have been applied to different domains and achieved dramatic performance improvements over state-of-the-art classical methods. These performances of DNNs were however often obtained with networks containing millions of parameters and which training required heavy computational power. In order to cope with this computational issue a huge literature deals with proximal regularization methods which are time consuming.\\ In this paper, we propose instead a constrained approach. We provide the general framework for our new splitting projection gradient method. Our splitting algorithm iterates a gradient step and a projection on convex sets. We study algorithms for different constraints: the classical $\ell_1$ unstructured constraint and structured constraints such as the nuclear norm, the $\ell_{2,1} $ constraint (Group LASSO). We propose a new $\ell_{1,1} $ structured constraint for which we provide a new projection algorithm We demonstrate the effectiveness of our method on three popular datasets (MNIST, Fashion MNIST and CIFAR). Experiments on these datasets show that our splitting projection method with our new $\ell_{1,1} $ structured constraint provides the best reduction of memory and computational power. Experiments show that fully connected linear DNN are more efficient for green AI.

Attack-Agnostic Adversarial Detection on Medical Data Using Explainable Machine Learning

Matthew Watson, Noura Al Moubayed

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Auto-TLDR; Explainability-based Detection of Adversarial Samples on EHR and Chest X-Ray Data

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Explainable machine learning has become increasingly prevalent, especially in healthcare where explainable models are vital for ethical and trusted automated decision making. Work on the susceptibility of deep learning models to adversarial attacks has shown the ease of designing samples to mislead a model into making incorrect predictions. In this work, we propose an explainability-based method for the accurate detection of adversarial samples on two datasets with different complexity and properties: Electronic Health Record (EHR) and chest X-ray (CXR) data. On the MIMIC-III and Henan-Renmin EHR datasets, we report a detection accuracy of 77% against the Longitudinal Adversarial Attack. On the MIMIC-CXR dataset, we achieve an accuracy of 88%; significantly improving on the state of the art of adversarial detection in both datasets by over 10% in all settings. We propose an anomaly detection based method using explainability techniques to detect adversarial samples which is able to generalise to different attack methods without a need for retraining.

Ancient Document Layout Analysis: Autoencoders Meet Sparse Coding

Homa Davoudi, Marco Fiorucci, Arianna Traviglia

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Auto-TLDR; Unsupervised Unsupervised Representation Learning for Document Layout Analysis

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Layout analysis of historical handwritten documents is a key pre-processing step in document image analysis that, by segmenting the image into its homogeneous regions, facilitates subsequent procedures such as optical character recognition and automatic transcription. Learning-based approaches have shown promising performances in layout analysis, however, the majority of them requires tedious pixel-wise labelled training data to achieve generalisation capabilities, this limitation preventing their application due to the lack of large labelled datasets. This paper proposes a novel unsupervised representation learning method for documents’ layout analysis that reduces the need for labelled data: a sparse autoencoder is first trained in an unsupervised manner on a historical text document’s image; representation of image patches, computed by the sparse encoder, is then used to classify pixels into various region categories of the document using a feed-forward neural network. A new training method, inspired by the ISTA algorithm, is also introduced here to train the sparse encoder. Experimental results on DIVA-HisDB dataset demonstrate that the proposed method outperforms previous approaches based on unsupervised representation learning while achieving performances comparable to the state-of-the-art fully supervised methods.

Color, Edge, and Pixel-Wise Explanation of Predictions Based onInterpretable Neural Network Model

Jay Hoon Jung, Youngmin Kwon

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Auto-TLDR; Explainable Deep Neural Network with Edge Detecting Filters

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We design an interpretable network model by introducing explainable components into a Deep Neural Network (DNN). We substituted the first kernels of a Convolutional Neural Network (CNN) and a ResNet-50 with the well-known edge detecting filters such as Sobel, Prewitt, and other filters. Each filters' relative importance scores are measured with a variant of Layer-wise Relevance Propagation (LRP) method proposed by Bach et al. Since the effects of the edge detecting filters are well understood, our model provides three different scores to explain individual predictions: the scores with respect to (1) colors, (2) edge filters, and (3) pixels of the image. Our method provides more tools to analyze the predictions by highlighting the location of important edges and colors in the images. Furthermore, the general features of a category can be shown in our scores as well as individual predictions. At the same time, the model does not degrade performances on MNIST, Fruit360 and ImageNet datasets.

Multi-Label Contrastive Focal Loss for Pedestrian Attribute Recognition

Xiaoqiang Zheng, Zhenxia Yu, Lin Chen, Fan Zhu, Shilong Wang

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Auto-TLDR; Multi-label Contrastive Focal Loss for Pedestrian Attribute Recognition

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Pedestrian Attribute Recognition (PAR) has received extensive attention during the past few years. With the advances of deep constitutional neural networks (CNNs), the performance of PAR has been significantly improved. Existing methods tend to acquire attribute-specific features by designing various complex network structures with additional modules. Such additional modules, however, dramatically increase the number of parameters. Meanwhile, the problems of class imbalance and hard attribute retrieving remain underestimated in PAR. In this paper, we explore the optimization mechanism of the training processing to account for these problems and propose a new loss function called Multi-label Contrastive Focal Loss (MCFL). This proposed MCFL emphasizes the hard and minority attributes by using a separated re-weighting mechanism for different positive and negative classes to alleviate the impact of the imbalance. MCFL is also able to enlarge the gaps between the intra-class of multi-label attributes, to force CNNs to extract more subtle discriminative features. We evaluate the proposed MCFL on three large public pedestrian datasets, including RAP, PA-100K, and PETA. The experimental results indicate that the proposed MCFL with the ResNet-50 backbone is able to outperform other state-of-the-art approaches in comparison.

Explainable Feature Embedding Using Convolutional Neural Networks for Pathological Image Analysis

Kazuki Uehara, Masahiro Murakawa, Hirokazu Nosato, Hidenori Sakanashi

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Auto-TLDR; Explainable Diagnosis Using Convolutional Neural Networks for Pathological Image Analysis

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The development of computer-assisted diagnosis (CAD) algorithms for pathological image analysis constitutes an important research topic. Recently, convolutional neural networks (CNNs) have been used in several studies for the development of CAD algorithms. Such systems are required to be not only accurate but also explainable for their decisions, to ensure reliability. However, a limitation of using CNNs is that the basis of the decisions made by them are incomprehensible to humans. Thus, in this paper, we present an explainable diagnosis method, which comprises of two CNNs for different rolls. This method allows us to interpret the basis of the decisions made by CNN from two perspectives, namely statistics and visualization. For the statistical explanation, the method constructs a dictionary of representative pathological features. It performs diagnoses based on the occurrence and importance of learned features referred from its dictionary. To construct the dictionary, we introduce a vector quantization scheme for CNN. For the visual interpretation, the method provides images of learned features embedded in a high-dimensional feature space as an index of the dictionary by generating them using a conditional autoregressive model. The experimental results showed that the proposed network learned pathological features, which contributed to the diagnosis and yielded an area under the receiver operating curve (AUC) of approximately 0.93 for detecting atypical tissues in pathological images of the uterine cervix. Moreover, the proposed method demonstrated that it could provide visually interpretable images to show the rationales behind its decisions. Thus, the proposed method can serve as a valuable tool for pathological image analysis in terms of both its accuracy and explainability.

Activity and Relationship Modeling Driven Weakly Supervised Object Detection

Yinlin Li, Yang Qian, Xu Yang, Yuren Zhang

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Auto-TLDR; Weakly Supervised Object Detection Using Activity Label and Relationship Modeling

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This paper presents a weakly supervised object detection method based on activity label and relationship modeling, which is motivated by the assumption that configuration of human and object are similar in same activity, and joint modeling of human, active object and activity could leverage the recognition of them. Compared to most weakly supervised method taking object as independent instance, firstly, active human and object proposals are learned and filtered based on class activation map of multi-label classification. Secondly, a spatial relationship prior including relative position, scale, overlaps etc are learned dependent on action. Finally, a multi-stream object detection framework integrating the spatial prior and pairwise ROI pooling are proposed to jointly learn the object and action class. Experiments are conducted on HICO-DET dataset, and our approach outperforms the state of the art weakly supervised object detection methods.

Dependently Coupled Principal Component Analysis for Bivariate Inversion Problems

Navdeep Dahiya, Yifei Fan, Samuel Bignardi, Tony Yezzi, Romeil Sandhu

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Auto-TLDR; Asymmetric Principal Component Analysis between Paired Data in an Asymmetric manner

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Principal Component Analysis (PCA) is a widely used technique for dimensionality reduction in various problem domains including data compression, image processing, visualization, exploratory data analysis, pattern recognition, time series prediction and machine learning. Often, data is presented in a correlated paired manner such there exists observable and correlated unobservable measurements. Unfortunately, traditional PCA techniques generally fail to optimally capture the leverageable correlations between such paired data as it does not yield a maximally correlated basis between the observable and unobservable counterparts. This instead is the objective of Canonical Correlation Analysis (and the more general Partial Least Squares methods); however, such techniques are still symmetric in maximizing correlation (covariance for PLSR) over all choices of basis for both datasets without differentiating between observable and unobservable variables (except for the regression phase of PLSR). Further, these methods deviate from PCA's formulation objective to minimize approximation error, seeking instead to maximize correlation or covariance. While these are sensible optimization objectives, they are not equivalent to error minimization. We therefore introduce a new method of leveraging PCA between paired datasets in an asymmetric manner which is optimal with respect to approximation error during training. We generate an asymmetrically paired basis for which we relax orthogonality constraints on the orthogonality in decomposing unreliable unobservable measurements. In doing so, this allows us to optimally capture the variations of the observable data while conditionally minimizing the expected prediction error for the unobservable component. We show preliminary results that demonstrate improved learning of our proposed method compared to that of traditional techniques.

Trainable Spectrally Initializable Matrix Transformations in Convolutional Neural Networks

Michele Alberti, Angela Botros, Schuetz Narayan, Rolf Ingold, Marcus Liwicki, Mathias Seuret

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Auto-TLDR; Trainable and Spectrally Initializable Matrix Transformations for Neural Networks

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In this work, we introduce a new architectural component to Neural Networks (NN), i.e., trainable and spectrally initializable matrix transformations on feature maps. While previous literature has already demonstrated the possibility of adding static spectral transformations as feature processors, our focus is on more general trainable transforms. We study the transforms in various architectural configurations on four datasets of different nature: from medical (ColorectalHist, HAM10000) and natural (Flowers) images to historical documents (CB55). With rigorous experiments that control for the number of parameters and randomness, we show that networks utilizing the introduced matrix transformations outperform vanilla neural networks. The observed accuracy increases appreciably across all datasets. In addition, we show that the benefit of spectral initialization leads to significantly faster convergence, as opposed to randomly initialized matrix transformations. The transformations are implemented as auto-differentiable PyTorch modules that can be incorporated into any neural network architecture. The entire code base is open-source.

Feature Extraction and Selection Via Robust Discriminant Analysis and Class Sparsity

Ahmad Khoder, Fadi Dornaika

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Auto-TLDR; Hybrid Linear Discriminant Embedding for supervised multi-class classification

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The main goal of discriminant embedding is to extract features that can be compact and informative representations of the original set of features. This paper introduces a hybrid scheme for linear feature extraction for supervised multi-class classification. We introduce a unifying criterion that is able to retain the advantages of robust sparse LDA and Inter-class sparsity. Thus, the estimated transformation includes two types of discrimination which are the inter-class sparsity and robust Linear Discriminant Analysis with feature selection. In order to optimize the proposed objective function, we deploy an iterative alternating minimization scheme for estimating the linear transformation and the orthogonal matrix. The introduced scheme is generic in the sense that it can be used for combining and tuning many other linear embedding methods. In the lights of the experiments conducted on six image datasets including faces, objects, and digits, the proposed scheme was able to outperform competing methods in most of the cases.

Discriminative Multi-Level Reconstruction under Compact Latent Space for One-Class Novelty Detection

Jaewoo Park, Yoon Gyo Jung, Andrew Teoh

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Auto-TLDR; Discriminative Compact AE for One-Class novelty detection and Adversarial Example Detection

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In one-class novelty detection, a model learns solely on the in-class data to single out out-class instances. Autoencoder (AE) variants aim to compactly model the in-class data to reconstruct it exclusively, thus differentiating the in-class from out-class by the reconstruction error. However, compact modeling in an improper way might collapse the latent representations of the in-class data and thus their reconstruction, which would lead to performance deterioration. Moreover, to properly measure the reconstruction error of high-dimensional data, a metric is required that captures high-level semantics of the data. To this end, we propose Discriminative Compact AE (DCAE) that learns both compact and collapse-free latent representations of the in-class data, thereby reconstructing them both finely and exclusively. In DCAE, (a) we force a compact latent space to bijectively represent the in-class data by reconstructing them through internal discriminative layers of generative adversarial nets. (b) Based on the deep encoder's vulnerability to open set risk, out-class instances are encoded into the same compact latent space and reconstructed poorly without sacrificing the quality of in-class data reconstruction. (c) In inference, the reconstruction error is measured by a novel metric that computes the dissimilarity between a query and its reconstruction based on the class semantics captured by the internal discriminator. Extensive experiments on public image datasets validate the effectiveness of our proposed model on both novelty and adversarial example detection, delivering state-of-the-art performance.

Learning to Segment Clustered Amoeboid Cells from Brightfield Microscopy Via Multi-Task Learning with Adaptive Weight Selection

Rituparna Sarkar, Suvadip Mukherjee, Elisabeth Labruyere, Jean-Christophe Olivo-Marin

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Auto-TLDR; Supervised Cell Segmentation from Microscopy Images using Multi-task Learning in a Multi-Task Learning Paradigm

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Detecting and segmenting individual cells from microscopy images is critical to various life science applications. Traditional cell segmentation tools are often ill-suited for applications in brightfield microscopy due to poor contrast and intensity heterogeneity, and only a small subset are applicable to segment cells in a cluster. In this regard, we introduce a novel supervised technique for cell segmentation in a multi-task learning paradigm. A combination of a multi-task loss, based on the region and cell boundary detection, is employed for an improved prediction efficiency of the network. The learning problem is posed in a novel min-max framework which enables adaptive estimation of the hyper-parameters in an automatic fashion. The region and cell boundary predictions are combined via morphological operations and active contour model to segment individual cells. The proposed methodology is particularly suited to segment touching cells from brightfield microscopy images without manual interventions. Quantitatively, we observe an overall Dice score of 0.93 on the validation set, which is an improvement of over 15.9% on a recent unsupervised method, and outperforms the popular supervised U-net algorithm by at least 5.8% on average.

Separation of Aleatoric and Epistemic Uncertainty in Deterministic Deep Neural Networks

Denis Huseljic, Bernhard Sick, Marek Herde, Daniel Kottke

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Auto-TLDR; AE-DNN: Modeling Uncertainty in Deep Neural Networks

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Despite the success of deep neural networks (DNN) in many applications, their ability to model uncertainty is still significantly limited. For example, in safety-critical applications such as autonomous driving, it is crucial to obtain a prediction that reflects different types of uncertainty to address life-threatening situations appropriately. In such cases, it is essential to be aware of the risk (i.e., aleatoric uncertainty) and the reliability (i.e., epistemic uncertainty) that comes with a prediction. We present AE-DNN, a model allowing the separation of aleatoric and epistemic uncertainty while maintaining a proper generalization capability. AE-DNN is based on deterministic DNN, which can determine the respective uncertainty measures in a single forward pass. In analyses with synthetic and image data, we show that our method improves the modeling of epistemic uncertainty while providing an intuitively understandable separation of risk and reliability.

Classification of Intestinal Gland Cell-Graphs Using Graph Neural Networks

Linda Studer, Jannis Wallau, Heather Dawson, Inti Zlobec, Andreas Fischer

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Auto-TLDR; Graph Neural Networks for Classification of Dysplastic Gland Glands using Graph Neural Networks

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We propose to classify intestinal glands as normal or dysplastic using cell-graphs and graph-based deep learning methods. Dysplastic intestinal glands can lead to colorectal cancer, which is one of the three most common cancer types in the world. In order to assess the cancer stage and thus the treatment of a patient, pathologists analyse tissue samples of affected patients. Among other factors, they look at the changes in morphology of different tissues, such as the intestinal glands. Cell-graphs have a high representational power and can describe topological and geometrical properties of intestinal glands. However, classical graph-based methods have a high computational complexity and there is only a limited range of machine learning methods available. In this paper, we propose Graph Neural Networks (GNNs) as an efficient learning-based approach to classify cell-graphs. We investigate different variants of so-called Message Passing Neural Networks and compare them with a classical graph-based approach based on approximated Graph Edit Distance and k-nearest neighbours classifier. A promising classification accuracy of 94.1% is achieved by the proposed method on the pT1 Gland Graph dataset, which is an increase of 11.5% over the baseline result.

Weakly Supervised Learning through Rank-Based Contextual Measures

João Gabriel Camacho Presotto, Lucas Pascotti Valem, Nikolas Gomes De Sá, Daniel Carlos Guimaraes Pedronette, Joao Paulo Papa

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Auto-TLDR; Exploiting Unlabeled Data for Weakly Supervised Classification of Multimedia Data

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Machine learning approaches have achieved remarkable advances over the last decades, especially in supervised learning tasks such as classification. Meanwhile, multimedia data and applications experienced an explosive growth, becoming ubiquitous in diverse domains. Due to the huge increase in multimedia data collections and the lack of labeled data in several scenarios, creating methods capable of exploiting the unlabeled data and operating under weakly supervision is imperative. In this work, we propose a rank-based model to exploit contextual information encoded in the unlabeled data in order to perform weakly supervised classification. We employ different rank-based correlation measures for identifying strong similarities relationships and expanding the labeled set in an unsupervised way. Subsequently, the extended labeled set is used by a classifier to achieve better accuracy results. The proposed weakly supervised approach was evaluated on multimedia classification tasks, considering several combinations of rank correlation measures and classifiers. An experimental evaluation was conducted on 4 public image datasets and different features. Very positive gains were achieved in comparison with various semi-supervised and supervised classifiers taken as baselines when considering the same amount of labeled data.

Dealing with Scarce Labelled Data: Semi-Supervised Deep Learning with Mix Match for Covid-19 Detection Using Chest X-Ray Images

Saúl Calderón Ramirez, Raghvendra Giri, Shengxiang Yang, Armaghan Moemeni, Mario Umaña, David Elizondo, Jordina Torrents-Barrena, Miguel A. Molina-Cabello

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Auto-TLDR; Semi-supervised Deep Learning for Covid-19 Detection using Chest X-rays

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Coronavirus (Covid-19) is spreading fast, infecting people through contact in various forms including droplets from sneezing and coughing. Therefore, the detection of infected subjects in an early, quick and cheap manner is urgent. Currently available tests are scarce and limited to people in danger of serious illness. The application of deep learning to chest X-ray images for Covid-19 detection is an attractive approach. However, this technology usually relies on the availability of large labelled datasets, a requirement hard to meet in the context of a virus outbreak. To overcome this challenge, a semi-supervised deep learning model using both labelled and unlabelled data is proposed. We developed and tested a semi-supervised deep learning framework based on the Mix Match architecture to classify chest X-rays into Covid-19, pneumonia and healthy cases. The presented approach was calibrated using two publicly available datasets. The results show an accuracy increase of around $15\%$ under low labelled / unlabelled data ratio. This indicates that our semi-supervised framework can help improve performance levels towards Covid-19 detection when the amount of high-quality labelled data is scarce. Also, we introduce a semi-supervised deep learning boost coefficient which is meant to ease the scalability of our approach and performance comparison.

Improving Model Accuracy for Imbalanced Image Classification Tasks by Adding a Final Batch Normalization Layer: An Empirical Study

Veysel Kocaman, Ofer M. Shir, Thomas Baeck

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Auto-TLDR; Exploiting Batch Normalization before the Output Layer in Deep Learning for Minority Class Detection in Imbalanced Data Sets

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Some real-world domains, such as Agriculture and Healthcare, comprise early-stage disease indications whose recording constitutes a rare event, and yet, whose precise detection at that stage is critical. In this type of highly imbalanced classification problems, which encompass complex features, deep learning (DL) is much needed because of its strong detection capabilities. At the same time, DL is observed in practice to favor majority over minority classes and consequently suffer from inaccurate detection of the targeted early-stage indications. To simulate such scenarios, we artificially generate skewness (99% vs. 1%) for certain plant types out of the PlantVillage dataset as a basis for classification of scarce visual cues through transfer learning. By randomly and unevenly picking healthy and unhealthy samples from certain plant types to form a training set, we consider a base experiment as fine-tuning ResNet34 and VGG19 architectures and then testing the model performance on a balanced dataset of healthy and unhealthy images. We empirically observe that the initial F1 test score jumps from 0.29 to 0.95 for the minority class upon adding a final Batch Normalization (BN) layer just before the output layer in VGG19. We demonstrate that utilizing an additional BN layer before the output layer in modern CNN architectures has a considerable impact in terms of minimizing the training time and testing error for minority classes in highly imbalanced data sets. Moreover, when the final BN is employed, trying to minimize validation and training losses may not be an optimal way for getting a high F1 test score for minority classes in anomaly detection problems. That is, the network might perform better even if it is not ‘confident’ enough while making a prediction; leading to another discussion about why softmax output is not a good uncertainty measure for DL models.

Malware Detection by Exploiting Deep Learning over Binary Programs

Panpan Qi, Zhaoqi Zhang, Wei Wang, Chang Yao

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Auto-TLDR; End-to-End Malware Detection without Feature Engineering

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Malware evolves rapidly over time, which makes existing solutions being ineffective in detecting newly released malware. Machine learning models that can learn to capture malicious patterns directly from the data play an increasingly important role in malware analysis. However, traditional machine learning models heavily depend on feature engineering. The extracted static features are vulnerable as hackers could create new malware with different feature values to deceive the machine learning models. In this paper, we propose an end-to-end malware detection framework consisting of convolutional neural network, autoencoder and neural decision trees. It learns the features from multiple domains for malware detection without feature engineering. In addition, since anti-virus products should have a very low false alarm rate to avoid annoying users, we propose a special loss function, which optimizes the recall for a fixed low false positive rate (e.g., less than 0.1%). Experiments show that the proposed framework has achieved a better recall than the baseline models, and the derived loss function also makes a difference.

Triplet-Path Dilated Network for Detection and Segmentation of General Pathological Images

Jiaqi Luo, Zhicheng Zhao, Fei Su, Limei Guo

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Auto-TLDR; Triplet-path Network for One-Stage Object Detection and Segmentation in Pathological Images

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Deep learning has been widely applied in the field of medical image processing. However, compared with flourishing visual tasks in natural images, the progress achieved in pathological images is not remarkable, and detection and segmentation, which are among basic tasks of computer vision, are regarded as two independent tasks. In this paper, we make full use of existing datasets and construct a triplet-path network using dilated convolutions to cooperatively accomplish one-stage object detection and nuclei segmentation for general pathological images. First, in order to meet the requirement of detection and segmentation, a novel structure called triplet feature generation (TFG) is designed to extract high-resolution and multiscale features, where features from different layers can be properly integrated. Second, considering that pathological datasets are usually small, a location-aware and partially truncated loss function is proposed to improve the classification accuracy of datasets with few images and widely varying targets. We compare the performance of both object detection and instance segmentation with state-of-the-art methods. Experimental results demonstrate the effectiveness and efficiency of the proposed network on two datasets collected from multiple organs.

A Comparison of Neural Network Approaches for Melanoma Classification

Maria Frasca, Michele Nappi, Michele Risi, Genoveffa Tortora, Alessia Auriemma Citarella

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Auto-TLDR; Classification of Melanoma Using Deep Neural Network Methodologies

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Melanoma is the deadliest form of skin cancer and it is diagnosed mainly visually, starting from initial clinical screening and followed by dermoscopic analysis, biopsy and histopathological examination. A dermatologist’s recognition of melanoma may be subject to errors and may take some time to diagnose it. In this regard, deep learning can be useful in the study and classification of skin cancer. In particular, by classifying images with Deep Neural Network methodologies, it is possible to obtain comparable or even superior results compared to those of dermatologists. In this paper, we propose a methodology for the classification of melanoma by adopting different deep learning techniques applied to a common dataset, composed of images from the ISIC dataset and consisting of different types of skin diseases, including melanoma on which we applied a specific pre-processing phase. In particular, a comparison of the results is performed in order to select the best effective neural network to be applied to the problem of recognition and classification of melanoma. Moreover, we also evaluate the impact of the pre- processing phase on the final classification. Different metrics such as accuracy, sensitivity, and specificity have been selected to assess the goodness of the adopted neural networks and compare them also with the manual classification of dermatologists.

EasiECG: A Novel Inter-Patient Arrhythmia Classification Method Using ECG Waves

Chuanqi Han, Ruoran Huang, Fang Yu, Xi Huang, Li Cui

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Auto-TLDR; EasiECG: Attention-based Convolution Factorization Machines for Arrhythmia Classification

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Abstract—In an ECG record, the PQRST waves are of important medical significance which provide ample information reflecting heartbeat activities. In this paper, we propose a novel arrhythmia classification method namely EasiECG, characterized by simplicity and accuracy. Compared with other works, the EasiECG takes the configuration of these five key waves into account and does not require complicated feature engineering. Meanwhile, an additional encoding of the extracted features makes the EasiECG applicable even on samples with missing waves. To automatically capture interactions that contribute to the classification among the processed features, a novel adapted classification model named Attention-based Convolution Factorization Machines (ACFM) is proposed. In detail, the ACFM can learn both linear and high-order interactions from linear regression and convolution on outer-product feature interaction maps, respectively. After that, an attention mechanism implemented in the model can further assign different importance of these interactions when predicting certain types of heartbeats. To validate the effectiveness and practicability of our EasiECG, extensive experiments of inter-patient paradigm on the benchmark MIT-BIH arrhythmia database are conducted. To tackle the imbalanced sample problem in this dataset, an ingenious loss function: focal loss is adopted when training. The experiment results show that our method is competitive compared with other state-of-the-arts, especially in classifying the Supraventricular ectopic beats. Besides, the EasiECG achieves an overall accuracy of 87.6% on samples with a missing wave in the related experiment, demonstrating the robustness of our proposed method.

Multi-Modal Deep Clustering: Unsupervised Partitioning of Images

Guy Shiran, Daphna Weinshall

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Auto-TLDR; Multi-Modal Deep Clustering for Unlabeled Images

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The clustering of unlabeled raw images is a daunting task, which has recently been approached with some success by deep learning methods. Here we propose an unsupervised clustering framework, which learns a deep neural network in an end-to-end fashion, providing direct cluster assignments of images without additional processing. Multi-Modal Deep Clustering (MMDC), trains a deep network to align its image embeddings with target points sampled from a Gaussian Mixture Model distribution. The cluster assignments are then determined by mixture component association of image embeddings. Simultaneously, the same deep network is trained to solve an additional self-supervised task. This pushes the network to learn more meaningful image representations and stabilizes the training. Experimental results show that MMDC achieves or exceeds state-of-the-art performance on four challenging benchmarks. On natural image datasets we improve on previous results with significant margins of up to 11% absolute accuracy points, yielding an accuracy of 70% on CIFAR-10 and 61% on STL-10.

RNN Training along Locally Optimal Trajectories via Frank-Wolfe Algorithm

Yun Yue, Ming Li, Venkatesh Saligrama, Ziming Zhang

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Auto-TLDR; Frank-Wolfe Algorithm for Efficient Training of RNNs

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We propose a novel and efficient training method for RNNs by iteratively seeking a local minima on the loss surface within a small region, and leverage this directional vector for the update, in an outer-loop. We propose to utilize the Frank-Wolfe (FW) algorithm in this context. Although, FW implicitly involves normalized gradients, which can lead to a slow convergence rate, we develop a novel RNN training method that, surprisingly, even with the additional cost, the overall training cost is empirically observed to be lower than back-propagation. Our method leads to a new Frank-Wolfe method, that is in essence an SGD algorithm with a restart scheme. We prove that under certain conditions our algorithm has a sublinear convergence rate of $O(1/\epsilon)$ for $\epsilon$ error. We then conduct empirical experiments on several benchmark datasets including those that exhibit long-term dependencies, and show significant performance improvement. We also experiment with deep RNN architectures and show efficient training performance. Finally, we demonstrate that our training method is robust to noisy data.

Low-Cost Lipschitz-Independent Adaptive Importance Sampling of Stochastic Gradients

Huikang Liu, Xiaolu Wang, Jiajin Li, Man-Cho Anthony So

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Auto-TLDR; Adaptive Importance Sampling for Stochastic Gradient Descent

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Stochastic gradient descent (SGD) usually samples training data based on the uniform distribution, which may not be a good choice because of the high variance of its stochastic gradient. Thus, importance sampling methods are considered in the literature to improve the performance. Most previous work on SGD-based methods with importance sampling requires the knowledge of Lipschitz constants of all component gradients, which are in general difficult to estimate. In this paper, we study an adaptive importance sampling method for common SGD-based methods by exploiting the local first-order information without knowing any Lipschitz constants. In particular, we periodically changes the sampling distribution by only utilizing the gradient norms in the past few iterations. We prove that our adaptive importance sampling non-asymptotically reduces the variance of the stochastic gradients in SGD, and thus better convergence bounds than that for vanilla SGD can be obtained. We extend this sampling method to several other widely used stochastic gradient algorithms including SGD with momentum and ADAM. Experiments on common convex learning problems and deep neural networks illustrate notably enhanced performance using the adaptive sampling strategy.

Soft Label and Discriminant Embedding Estimation for Semi-Supervised Classification

Fadi Dornaika, Abdullah Baradaaji, Youssof El Traboulsi

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Auto-TLDR; Semi-supervised Semi-Supervised Learning for Linear Feature Extraction and Label Propagation

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In recent times, graph-based semi-supervised learning proved to be a powerful paradigm for processing and mining large datasets. The main advantage relies on the fact that these methods can be useful in propagating a small set of known labels to a large set of unlabeled data. The scarcity of labeled data may affect the performance of the semi-learning. This paper introduces a new semi-supervised framework for simultaneous linear feature extraction and label propagation. The proposed method simultaneously estimates a discriminant transformation and the unknown label by exploiting both labeled and unlabeled data. In addition, the unknowns of the learning model are estimated by integrating two types of graph-based smoothness constraints. The resulting semi-supervised model is expected to learn more discriminative information. Experiments are conducted on six public image datasets. These experimental results show that the performance of the proposed method can be better than that of many state-of-the-art graph-based semi-supervised algorithms.

Supporting Skin Lesion Diagnosis with Content-Based Image Retrieval

Stefano Allegretti, Federico Bolelli, Federico Pollastri, Sabrina Longhitano, Giovanni Pellacani, Costantino Grana

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Auto-TLDR; Skin Images Retrieval Using Convolutional Neural Networks for Skin Lesion Classification and Segmentation

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Given the relevance of skin cancer, many attempts have been dedicated to the creation of automated devices that could assist both expert and beginner dermatologists towards fast and early diagnosis of skin lesions. In recent years, tasks such as skin lesion classification and segmentation have been extensively addressed with deep learning algorithms, which in some cases reach a diagnostic accuracy comparable to that of expert physicians. However, the general lack of interpretability and reliability severely hinders the ability of those approaches to actually support dermatologists in the diagnosis process. In this paper a novel skin images retrieval system is presented, which exploits features extracted by Convolutional Neural Networks to gather similar images from a publicly available dataset, in order to assist the diagnosis process of both expert and novice practitioners. In the proposed framework, Resnet-50 is initially trained for the classification of dermoscopic images; then, the feature extraction part is isolated, and an embedding network is build on top of it. The embedding learns an alternative representation, which allows to check image similarity by means of a distance measure. Experimental results reveal that the proposed method is able to select meaningful images, which can effectively boost the classification accuracy of human dermatologists.

Multi-Scale and Attention Based ResNet for Heartbeat Classification

Haojie Zhang, Gongping Yang, Yuwen Huang, Feng Yuan, Yilong Yin

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Auto-TLDR; A Multi-Scale and Attention based ResNet for ECG heartbeat classification in intra-patient and inter-patient paradigms

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This paper presents a novel deep learning framework for the electrocardiogram (ECG) heartbeat classification. Although there have been some studies with excellent overall accuracy, these studies have not been very accurate in the diagnosis of arrhythmia classes especially such as supraventricular ectopic beat (SVEB) and ventricular ectopic beat (VEB). In our work, we propose a Multi-Scale and Attention based ResNet for heartbeat classification in intra-patient and inter-patient paradigms respectively. Firstly, we extract shallow features from a convolutional layer. Secondly, the shallow features are sent into three branches with different convolution kernels in order to combine receptive fields of different sizes. Finally, fully connected layers are used to classify the heartbeat. Besides, we design a new attention mechanism based on the characteristics of heartbeat data. At last, extensive experiments on benchmark dataset demonstrate the effectiveness of our proposed model.

End-To-End Multi-Task Learning for Lung Nodule Segmentation and Diagnosis

Wei Chen, Qiuli Wang, Dan Yang, Xiaohong Zhang, Chen Liu, Yucong Li

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Auto-TLDR; A novel multi-task framework for lung nodule diagnosis based on deep learning and medical features

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Computer-Aided Diagnosis (CAD) systems for lung nodule diagnosis based on deep learning have attracted much attention in recent years. However, most existing methods ignore the relationships between the segmentation and classification tasks, which leads to unstable performances. To address this problem, we propose a novel multi-task framework, which can provide lung nodule segmentation mask, malignancy prediction, and medical features for interpretable diagnosis at the same time. Our framework mainly contains two sub-network: (1) Multi-Channel Segmentation Sub-network (MSN) for lung nodule segmentation, and (2) Joint Classification Sub-network (JCN) for interpretable lung nodule diagnosis. In the proposed framework, we use U-Net down-sampling processes for extracting low-level deep learning features, which are shared by two sub-networks. The JCN forces the down-sampling processes to learn better lowlevel deep features, which lead to a better construct of segmentation masks. Meanwhile, two additional channels constructed by OTSU and super-pixel (SLIC) methods, are utilized as the guideline of the feature extraction. The proposed framework takes advantages of deep learning methods and classical methods, which can significantly improve the performances of all tasks. We evaluate the proposed framework on public dataset LIDCIDRI. Our framework achieves a promising Dice score of 86.43% in segmentation, 87.07% in malignancy level prediction, and convincing results in interpretable medical feature predictions.

Feature-Aware Unsupervised Learning with Joint Variational Attention and Automatic Clustering

Wang Ru, Lin Li, Peipei Wang, Liu Peiyu

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Auto-TLDR; Deep Variational Attention Encoder-Decoder for Clustering

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Deep clustering aims to cluster unlabeled real-world samples by mining deep feature representation. Most of existing methods remain challenging when handling high-dimensional data and simultaneously exploring the complementarity of deep feature representation and clustering. In this paper, we propose a novel Deep Variational Attention Encoder-decoder for Clustering (DVAEC). Our DVAEC improves the representation learning ability by fusing variational attention. Specifically, we design a feature-aware automatic clustering module to mitigate the unreliability of similarity calculation and guide network learning. Besides, to further boost the performance of deep clustering from a global perspective, we define a joint optimization objective to promote feature representation learning and automatic clustering synergistically. Extensive experimental results show the promising performance achieved by our DVAEC on six datasets comparing with several popular baseline clustering methods.

Evaluation of Anomaly Detection Algorithms for the Real-World Applications

Marija Ivanovska, Domen Tabernik, Danijel Skocaj, Janez Pers

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Auto-TLDR; Evaluating Anomaly Detection Algorithms for Practical Applications

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Anomaly detection in complex data structures is oneof the most challenging problems in computer vision. In manyreal-world problems, for example in the quality control in modernmanufacturing, the anomalous samples are usually rare, resultingin (highly) imbalanced datasets. However, in current researchpractice, these scenarios are rarely modeled, and as a conse-quence, evaluation of anomaly detection algorithms often do notreproduce results that are useful for practical applications. First,even in case of highly unbalanced input data, anomaly detectionalgorithms are expected to significantly reduce the proportionof anomalous samples, detecting ”almost all” anomalous samples(with exact specifications depending on the target customer). Thisplaces high importance on only the small part of the ROC curve,possibly rendering the standard metrics such as AUC (AreaUnder Curve) and AP (Average Precision) useless. Second, thetarget of automatic anomaly detection in practical applicationsis significant reduction in manual work required, and standardmetrics are poor predictor of this feature. Finally, the evaluationmay produce erratic results for different randomly initializedtraining runs of the neural network, producing evaluation resultsthat may not reproduce well in practice. In this paper, we presentan evaluation methodology that avoids these pitfalls.

Investigating and Exploiting Image Resolution for Transfer Learning-Based Skin Lesion Classification

Amirreza Mahbod, Gerald Schaefer, Chunliang Wang, Rupert Ecker, Georg Dorffner, Isabella Ellinger

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Auto-TLDR; Fine-tuned Neural Networks for Skin Lesion Classification Using Dermoscopic Images

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Skin cancer is among the most common cancer types. Dermoscopic image analysis improves the diagnostic accuracy for detection of malignant melanoma and other pigmented skin lesions when compared to unaided visual inspection. Hence, computer-based methods to support medical experts in the diagnostic procedure are of great interest. Fine-tuning pre-trained convolutional neural networks (CNNs) has been shown to work well for skin lesion classification. Pre-trained CNNs are usually trained with natural images of a fixed image size which is typically significantly smaller than captured skin lesion images and consequently dermoscopic images are downsampled for fine-tuning. However, useful medical information may be lost during this transformation. In this paper, we explore the effect of input image size on skin lesion classification performance of fine-tuned CNNs. For this, we resize dermoscopic images to different resolutions, ranging from 64x64 to 768x768 pixels and investigate the resulting classification performance of three well-established CNNs, namely DenseNet-121, ResNet-18, and ResNet-50. Our results show that using very small images (of size 64x64 pixels) degrades the classification performance, while images of size 128x128 pixels and above support good performance with larger image sizes leading to slightly improved classification. We further propose a novel fusion approach based on a three-level ensemble strategy that exploits multiple fine-tuned networks trained with dermoscopic images at various sizes. When applied on the ISIC 2017 skin lesion classification challenge, our fusion approach yields an area under the receiver operating characteristic curve of 89.2% and 96.6% for melanoma classification and seborrheic keratosis classification, respectively, outperforming state-of-the-art algorithms.

Confidence Calibration for Deep Renal Biopsy Immunofluorescence Image Classification

Federico Pollastri, Juan Maroñas, Federico Bolelli, Giulia Ligabue, Roberto Paredes, Riccardo Magistroni, Costantino Grana

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Auto-TLDR; A Probabilistic Convolutional Neural Network for Immunofluorescence Classification in Renal Biopsy

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With this work we tackle immunofluorescence classification in renal biopsy, employing state-of-the-art Convolutional Neural Networks. In this setting, the aim of the probabilistic model is to assist an expert practitioner towards identifying the location pattern of antibody deposits within a glomerulus. Since modern neural networks often provide overconfident outputs, we stress the importance of having a reliable prediction, demonstrating that Temperature Scaling, a recently introduced re-calibration technique, can be successfully applied to immunofluorescence classification in renal biopsy. Experimental results demonstrate that the designed model yields good accuracy on the specific task, and that Temperature Scaling is able to provide reliable probabilities, which are highly valuable for such a task given the low inter-rater agreement.

The eXPose Approach to Crosslier Detection

Antonio Barata, Frank Takes, Hendrik Van Den Herik, Cor Veenman

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Auto-TLDR; EXPose: Crosslier Detection Based on Supervised Category Modeling

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Transit of wasteful materials within the European Union is highly regulated through a system of permits. Waste processing costs vary greatly depending on the waste category of a permit. Therefore, companies may have a financial incentive to allege transporting waste with erroneous categorisation. Our goal is to assist inspectors in selecting potentially manipulated permits for further investigation, making their task more effective and efficient. Due to data limitations, a supervised learning approach based on historical cases is not possible. Standard unsupervised approaches, such as outlier detection and data quality-assurance techniques, are not suited since we are interested in targeting non-random modifications in both category and category-correlated features. For this purpose we (1) introduce the concept of crosslier: an anomalous instance of a category which lies across other categories; (2) propose eXPose: a novel approach to crosslier detection based on supervised category modelling; and (3) present the crosslier diagram: a visualisation tool specifically designed for domain experts to easily assess crossliers. We compare eXPose against traditional outlier detection methods in various benchmark datasets with synthetic crossliers and show the superior performance of our method in targeting these instances.

Deep Ordinal Regression with Label Diversity

Axel Berg, Magnus Oskarsson, Mark Oconnor

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Auto-TLDR; Discrete Regression via Classification for Neural Network Learning

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Regression via classification (RvC) is a common method used for regression problems in deep learning, where the target variable belongs to a set of continuous values. By discretizing the target into a set of non-overlapping classes, it has been shown that training a classifier can improve neural network accuracy compared to using a standard regression approach. However, it is not clear how the set of discrete classes should be chosen and how it affects the overall solution. In this work, we propose that using several discrete data representations simultaneously can improve neural network learning compared to a single representation. Our approach is end-to-end differentiable and can be added as a simple extension to conventional learning methods, such as deep neural networks. We test our method on three challenging tasks and show that our method reduces the prediction error compared to a baseline RvC approach while maintaining a similar model complexity.

An Efficient Empirical Solver for Localized Multiple Kernel Learning Via DNNs

Ziming Zhang

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Auto-TLDR; Localized Multiple Kernel Learning using LMKL-Net

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In this paper we propose solving localized multiple kernel learning (LMKL) using LMKL-Net, a feedforward deep neural network (DNN). In contrast to previous works, as a learning principle we propose parameterizing the gating function for learning kernel combination weights and the multiclass classifier using an attentional network (AN) and a multilayer perceptron (MLP), respectively. Such interpretability helps us better understand how the network solves the problem. Thanks to stochastic gradient descent (SGD), our approach has {\em linear} computational complexity in training. Empirically on benchmark datasets we demonstrate that with comparable or better accuracy than the state-of-the-art, our LMKL-Net can be trained about {\bf two orders of magnitude} faster with about {\bf two orders of magnitude} smaller memory footprint for large-scale learning.

Image Representation Learning by Transformation Regression

Xifeng Guo, Jiyuan Liu, Sihang Zhou, En Zhu, Shihao Dong

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Auto-TLDR; Self-supervised Image Representation Learning using Continuous Parameter Prediction

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Self-supervised learning is a thriving research direction since it can relieve the burden of human labeling for machine learning by seeking for supervision from data instead of human annotation. Although demonstrating promising performance in various applications, we observe that the existing methods usually model the auxiliary learning tasks as classification tasks with finite discrete labels, leading to insufficient supervisory signals, which in turn restricts the representation quality. In this paper, to solve the above problem and make full use of the supervision from data, we design a regression model to predict the continuous parameters of a group of transformations, i.e., image rotation, translation, and scaling. Surprisingly, this naive modification stimulates tremendous potential from data and the resulting supervisory signal has largely improved the performance of image representation learning. Extensive experiments on four image datasets, including CIFAR10, CIFAR100, STL10, and SVHN, indicate that our proposed algorithm outperforms the state-of-the-art unsupervised learning methods by a large margin in terms of classification accuracy. Crucially, we find that with our proposed training mechanism as an initialization, the performance of the existing state-of-the-art classification deep architectures can be preferably improved.

Cross-View Relation Networks for Mammogram Mass Detection

Ma Jiechao, Xiang Li, Hongwei Li, Ruixuan Wang, Bjoern Menze, Wei-Shi Zheng

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Auto-TLDR; Multi-view Modeling for Mass Detection in Mammogram

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In medical image analysis, multi-view modeling is crucial for pathology detection when the target lesion is presented in different views, e.g. mass lesions in breast. Currently mammogram is the most effective imaging modality for mass lesion detection of breast cancer at the early stage. The pathological information from the two paired views (i.e., medio-lateral oblique and cranio-caudal) are highly relational and complementary, which is crucial for diagnosis in clinical practice. Existing mass detection methods do not consider learning synergistic features from the two relational views. For the first time, we propose a novel mass detection framework to capture the latent relation information from the two paired views of a same mass in mammogram. We evaluate our model on a public mammogram dataset and a large-scale private dataset, demonstrating that the proposed method outperforms existing feature fusion approaches and state-of-the-art mass detection methods. We further analyze the performance gains from the relation modeling. Our quantitative and qualitative results suggest that jointly learning cross-view features boosts the detection performance of existing models, which is a promising avenue for mass detection task in mammogram.